Multiscale Cardiovascular Engineering Group



Bridging organ and cellular-level behavior in ex-vivo experimental platforms using populations of models of cardiac electrophysiology

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Carlos Ledezma, Benjamin Kappler, Veronique Meijborg, Bas Boukens, Marco Stijnen, PJ Tan, Vanessa Díaz-Zuccarini. 

ASME Journal of Engineering and Science in Medical Diagnostics and Theraphy. doi:10.1115/1.4040589

A simplified method to account for wall motion in patient-specific blood flow simulations of Aortic Dissection: comparison with Fluid-Structure Interaction

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Mirko Bonfanti, Stavroula Balabani, Mona Alimohammadi, Obiekezie Agu, Shervanthi Homer-Vanniasinkam, Vanessa Díaz-Zuccarini. 

Medical Engineering and Physics. https://doi.org/10.1016/j.medengphy.2018.04.014

Computational Tools for Clinical Support - a Multi-Scale Compliant Model for Haemodynamic Simulations in an Aortic Dissection Based on Multi-Modal Imaging Data

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Mirko Bonfanti, Stavroula Balabani, John P. Greenwood, Sapna Puppala, Shervanthi Homer-Vanniasinkam, Vanessa Díaz-Zuccarini. 

Journal of the Royal Society Interface. DOI: 10.1098/rsif.2017.0632

Understanding the Effect of Statins and Patient Adherence in Atherosclerosis via a Quantitative Systems Pharmacology Model Using a Novel, Hybrid, and Multi-Scale Approach

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Front. Pharmacol., 13 September 2017 | https://doi.org/10.3389/fphar.2017.00635

Cesar Pichardo-Almarza and Vanessa Diaz-Zuccarini

A multiscale modelling approach to understand atherosclerosis formation: A patient-specific case study in the aortic bifurcation

This publication is OPEN ACCESS, please click on the link to get a copy

Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, Volume: 231 issue: 5, page(s): 378-390, May 2017.

Mona Alimohammadi, Cesar Pichardo-Almarza, Obiekezie Agu, Vanessa Diaz-Zuccarini

Patient-Specific, Multi-Scale Modeling of Neointimal Hyperplasia in Vein Grafts

This publication is OPEN ACCESS, please click on the link to get a copy

Frontiers in Physiology, special issue in Mathematics for Healthcare (doi: 10.3389/fphys.2017.00226)

Francesca Donadoni, Cesar Pichardo-Almarza, Matthew Bartlett, Alan Dardik, Shervanthi Homer-Vanniasinkam, Vanessa Diaz-Zuccarini

From PK/PD to QSP: Understanding the Dynamic Effect of Cholesterol-Lowering Drugs on Atherosclerosis Progression and Stratified Medicine

This publication is OPEN ACCESS, please click on the link to get a copy

Current Pharmaceutical Design, Volume 22, Issue 46, pages 6903 - 6910, 2016 (doi: 10.2174/1381612822666160905095402)

Cesar Pichardo-Almarza, Vanessa Diaz-Zuccarini

Development of a Patient-Specific Multi-Scale Model to Understand Atherosclerosis and Calcification Locations: Comparison with In vivo Data in an Aortic Dissection

This publication is OPEN ACCESS, please click on the link to get a copy

Frontiers in Physiology, special issue in Mathematics for Healthcare (doi: 10.3389/fphys.2016.00238)

Mona Alimohammadi, Cesar Pichardo, Obiekezie Agu, Vanessa Diaz-Zuccarini


A Multiscale and Patient-specific Computational Framework of Atherosclerosis Formation and Progression: A Case Study in the Aorta and Peripheral Arteries


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Procedia Computer Science, Volume 15, pages 118-1127, 2015 (doi:10.1016/j.procs.2015.05.281)

Giulia di Tomaso, Cesar Pichardo-Almarza, Obiekezie Agu, Vanessa Diaz-Zuccarini


Aortic dissection simulation models for clinical support: fluid-structure interaction vs. rigid wall models

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BioMedical Engineering OnLine 2015, 14:34 (doi:10.1186/s12938-015-0032-6)

Mona Alimohammadi, Joseph M Sherwood, Morad Karimpour, Obiekezie Agu, Stavroula Balabani and Vanessa Díaz-Zuccarini



Predicting Atherosclerotic Plaque Location in an Iliac Bifurcation Using a Hybrid CFD/Biomechanical Approach

Lecture Notes in Bioinformatics, as part of Lecture Notes in Computer Science, Volume 9044 2015, pp 594-606, April 2015

Mona Alimohamadi, Cesar Pichardo-Almarza, Giulia Di Tomaso, Stavroula Balabani, Obiekezie Agu and Vanessa Diaz-Zuccarini


Using a Systems Pharmacology Approach to Study the Effect of Statins on the Early Stage of Atherosclerosis in Humans

This publication is OPEN ACCESS, please click on the link to get a copy

CPT: Pharmacometrics & Systems Pharmacology, Volume 4, issue 1, January 2015.

Cesar Pichardo-Almarza, Lydia Metcalf, Anthony Finkelstein, Vanessa Diaz-Zuccarini.


Systems biology models to test physiological and pharmacological hypothesis in the study of atherosclerosis

Atherosclerosis. December 2014 Volume 237, Issue 2, Page e12

Cesar Pichardo-Almarza and Vanessa Diaz-Zuccarini


An in silico case study of idiopathic dilated cardiomyopathy via a multi-scale model of the cardiovascular system

Computers in Biology and Medicine (53) pp 141-153, October 2014.

Benjamin Bhattacharya-Ghosh, Selim Bozkurt, Marcel M.C Rutten, Frans N. van de Vosse, Vanessa Diaz-Zuccarini.

This paper was selected as one of the best in 2014 in the journal "Computers in Biology and Medicine". Click on the link to see!


Uncertainty assessment of imaging techniques for the 3D reconstruction of stent geometry

Medical Engineering and Physics (DOI: 10.1016/j.medengphy.2014.04.008) (in Press).

Daria Cosentino, Iwona Zwierzak, Silvia Schievano, Vanessa Díaz-Zuccarini, John W. Fenner, Andrew J. Narracott.


Influence of an arterial stenosis on the hemodynamics within an arteriovenous fistula (AVF): comparison before and after balloon-angioplasty

Cardiovascular Engineering and Technology (DOI: 10.1007/s13239-014-0185-7) (in press)

Iolanda Decorato, Anne-Virginie Salsac, Cécile Legallais, Mona Alimohammadi, Vanessa Diaz-Zuccarini, Zaher Kharboutly


Towards personalised management of atherosclerosis via computational models in vascular clinics: technology based on patient-specific simulation approach

Vanessa Díaz-Zuccarini; Giulia Di Tomaso; Obiekezie Agu; Cesar Pichardo-Almarza

Healthcare Technology Letters, issue 1, Vol. 1. Pp 13-18. March 2014.

This publication is OPEN ACCESS, please click on the link to get a copy.


Evaluation of the Hemodynamic Effectiveness of Aortic Dissection Treatments via Virtual Stenting

International Journal of Artificial Organs (DOI:10.5301/ijao.5000310) (in press)

Mona Alimohammadi, Benjamin Bhattacharya-Ghosh, Santhosh Seshadhri, Justin Penrose, Obiekezie Agu, Stavroula Balabani, Vanessa Díaz-Zuccarini


Stent Geometry Reconstruction Using Imaging Techniques

Journal of Medical Devices | Volume 7 | Issue 4 |

Daria Cosentino, Iwona Zwierzak, Vanessa Diaz-Zuccarini, John W. Fenner, Silvia Schievano and Andrew J. Narracott


Development of a patient-specific simulation tool to analyse aortic dissections: Assessment of mixed patient-specific flow and pressure boundary conditions

Medical Engineering and Physics (doi: 10.1016/j.medengphy.2013.11.003. [Epub ahead of print]

Alimohammadi M, Agu O, Balabani S, Díaz-Zuccarini V


A Vision and Strategy for the VPH: 2012 Update

Journal of the Royal Society Interface Focus, 6 April 2013 vol. 3 no. 2 20130004

Peter Hunter, Tara Chapman, Peter V. Coveney, Bernard de Bono, Vanessa Diaz, John Fenner, Alejandro F. Frangi, Peter Harris, Rod Hose, Peter Kohl, Pat Lawford, Keith McCormack, Miriam Mendes, Stig Omholt, Alfio Quarteroni, Nour Shublaq, John Skår, Karl Stroetmann, Jesper Tegner, S. Randall Thomas, Ioannis Tollis, Ioannis Tsamardinos, Johannes H. G. M. van Beek and Marco Viceconti


Physio-Environmental Sensing and Live Modeling

Interactive Journal of Medical Research doi.org/10.2196/ijmr.2092 

Filippo Castiglione; Vanessa Diaz; Andrea Gaggioli; Pietro Liò; Claudia Mazzà; Emanuela Merelli; Carel G.M Meskers; Francesco Pappalardo; Rainer von Ammon


Bridging Paradigms: Hybrid Mechanistic-Discriminative Predictive Models 

IEEE Trans Biomed Eng. 2013 Feb 4. [Epub ahead of print]

Orla Doyle, Krasimira Tsaneva-Atansaova, James Harte, Paul A.Tiffin, Peter Tino, Vanessa Díaz-Zuccarini  (accepted for publication).


Biomedical Imaging and Computational Modeling in Cardiovascular Disease: Patient-Specific Applications Using Numerical Models

Biomedical Imaging and Computational Modeling in Biomechanics

Lecture Notes in Computational Vision and Biomechanics Volume 4, 2013, pp 173-192

Vanessa Diaz Zuccarini, Silvia Schievano


A Multi-Physics and Multi-scale lumped parameter model of cardiac contraction of the left ventricle: A conceptual Model from the protein to the organ scale

Computers in Biology and Medicine, 2012

Benjamin Bhattacharya-Ghosh, Silvia Schievano, Vanessa Diaz Zuccarini


On the formalization of multi-scale and multi-science processes for integrative biology

Journal of the Royal Society Interface Focus, 2011

Diaz-Zuccarini V, Pichardo-Almarza C



A Multi-Scale Model of Atherosclerotic Plaque Formation at its Early Stage

IEEE Transactions in Biomedical Engineering, 2011

Di Tomaso G,Pichardo-Almarza C,Diaz Zuccarini V



Fluid-Structure Interaction Study of the Edge-to-Edge Repair Technique on the Mitral Valve

Journal of Biomechanics, 44,  2011, 2409-2417

Lau K, Diaz V, Scambler P, Burriesci G



The Virtual Physiological Human

Interface Focus, 1, 2011, 281-285

Coveney PV, Diaz VA, Hunter PH, Kohl P, Viceconti M


Mitral Valve dynamics in structural and fluid-structure interaction models.

Medical Engineering and Physics

Lau K, Diaz-Zuccarini V, Scambler P, Burriesci G



A Vision and Strategy for the VPH in 2010 and beyond

Philosophical Transactions of the Royal Society A, 2010

Hunter P,Van Beek H,de Bono B,Coveney P,Diaz V,Fenner J,Frangi A,Harris P,Hose DR,Kohl P,Lawford P,McCormack K,Mendes M,Omholt S,Quarteroni A,Skar J,Tegner J,Thomas SR,Tsamardinos I,Viceconti M



An In-Silico Future for the Engineering of Functional Tissues and Organs

Organogenesis, 6, 2010, 245-251

Diaz-Zuccarini V, Lawford PV



Virtual Physiological Human: training challenges

Philosophical Transactions of the Royal Society A, 368, 2010, 2841-2851

Lawford PV,Narracott AV,McCormack K,Bisbal J,Martin C,Bijnens B,Brook B,Zachariou M,Villà I Freixa J,Kohl P,Fletcher K,Diaz-Zuccarini V



Analysis of a mechanical heart valve prosthesis and a native venous valve: Two distinct applications of FSI to biomedical applications

International Journal for Numerical Methods in Biomedical Engineering, 26, 2010, 421-434

Narracott AJ, Zervides C, Diaz V, Rafiroiu D, Lawford PV, Hose DR



Researchers without Frontiers

Nature, 446, 2009, 466

Diaz V, Kofod G



Adaptation and development of software simulation methodologies for cardiovascular engineering: present and future challenges from an end-user perspective

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 367, 2009, 2655-2666

Díaz-Zuccarini V, Narracott AJ, Burriesci G, Zervides C, Rafiroiu D, Jones D, Hose DR, Lawford PV



Systemic modelling and computational physiology: The application of Bond Graph boundary conditions for 3D cardiovascular models

Simulation Modelling Practice and Theory, 17, 2009, 125-136

Diaz-Zuccarini V, Rafiroiu D, LeFevre J, Hose D R L, P V Lawford



Modelling and simulation of the mitral valve under physiological and pathological conditions: a primer study.

International Journal of Artificial Organs, 32, 2009, 400

Lau KD, Diaz V, Burriesci G, Scambler P



Investigations of the thrombogenic and cavitational potentials of a bileaflet mechanical heart valve, using ANSYS-CFX

IEEE International Conference onAutomation, Quality and Testing, Robotics, 2008; v3, 2008, 106-111

Turcu AE, Rafiroiu DV, Diaz-Zuccarini V, Narracott AJ, Hose DR, Lawford PV




Proceedings of the European Society of Biomechanics, 41, 2008, 241

Rafiroiu D, Diaz-Zuccarini V, Narracott A, Lawford PV, Hose DR



The Effect of Avalvulia on Venous Haemodynamics: a Numerical Investigation

Congenital Cardiology Today, 6, 2008, 10-15

Zervides C, Narracott AJ, Díaz-Zuccarini V, Burriesci G, Lawford PV, Hose DR



Multiphysics and Multiscale Simulation: Application to a Coupled Model of the Left Ventricle and a Mechanical Heart Valve

International Journal for Multiscale Computational Engineering, 6, 2008, 65-76

Diaz-Zuccarini V, Rafiroiu D, Hose D R L, P V N, A J Narracott



Multi-physics and Multi-scale Modelling in Cardiovascular Physiology: Advanced User Methods for Simulation of Biological Systems with ANSYSCFX

Lecture Notes in Computer Science, 4487, 2007, 794-801

Díaz-Zuccarini V, Rafirou D, Hose DR, Lawford PV, Narracott AJ



An energetically coherent lumped parameter model of the left ventricle specially developed for educational purposes

Computers in Biology and Medicine, 37, 2007, 774-784

Diaz-Zuccarini V, LeFèvre J



Coupling a bond graph model of the left ventricle with a CFX model of the aorta: a first approach

Journal of Biomechanics, 2006

Diaz V



A model of the left ventricle: from the mechanisms of contraction to Haemodynamics 

International Conference on Bond Graph Modelling ICBGM 03, 2003

Diaz-Zuccarini V, LeFevre J, Delgado M RA



Etude des conditions d'efficacite du ventricule gauche par optimisation teleonomique d'un modele de son fonctionnement

Thesis/Dissertation, 2003

Diaz-Zuccarini V