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LMCB - MRC Laboratory for Molecular Cell Biology

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Yann Desfougeres's picture

Postdoctoral Fellow, Saiardi Lab

y.desfougeres@ucl.ac.uk

Europe PMC | PubMed | ORCID

Research Synopsis

Phosphate is an essential component of life. It participates in the structure of the cell as a part of phospholipids, in the regulation of enzymatic reactions as a post-translational modification, in the inheritance of genetic material as a part of nucleic acids, and in most of biochemical reactions inside the cells as part of ATP, the main energy currency. My research brings together metabolism and signaling and focuses on how eukaryotic cells sense intracellular phosphate, how they deal with phosphate stores, and how they regulate the size of the different phosphate pools (inositol polyphosphate, inorganic polyphosphate, nucleotides pool, free phosphate). I am using two model systems to tackle the problem: yeast (Saccharomyces cerevisiae, Schizosaccharomyces pombe) and the social amoeba Dictyostelium discoideum.
 

Biography

2016 | Postdoctoral researcher, University of Lausanne, Switzerland
2009 | PhD, Biochemistry and Molecular Biology, Agrocampus Ouest, Rennes, France
2006 | Masters, Biochemistry and Molecular Biology, University of Rennes, France

Awards

2017 | Marie Skłodowska-Curie Fellowship

Funders

Medical Research Council, Marie Skłodowska-Curie Fellowship

Research Themes

Metabolism, Signalling pathways, Cell-cell interactions, Membrane trafficking
 

Technology

Light microscopy