The resolution of lymph node expansion and return to steady state is an unaddressed question, but perhaps understandably neglected since the immune cells migrate to the site of infection. Responsive lymph nodes need to expand both to accommodate thousands of naïve lymphocytes infiltrating and to provide additional space for their clonal proliferation in response to antigen. Lymph nodes undergo vast increases in organ size during adaptive immune responses and can undergo rapid and yet completely reversible remodeling countless times. My aim is to understand how homeostasis is regained as immune responses are resolved. Specifically, understand resident and recruited populations within the lymph nodes, and how cellular interactions drive tissue remodelling and the resolution of inflammation.
European Research Council
Cell migration, Tissue remodelling, Cell-cell interactions
Flow cytometry, Mass cytometry, Super-resolution microscopy, Light microscopy