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Giulia Paci's picture

Research Fellow, Mao and Baum Labs

g.paci@ucl.ac.uk

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Research Synopsis

Throughout animal development, tissues with distinct morphologies and functions have to assume their specific 3D shape under the continuous influence of mechanical forces. These forces can be intrinsic to the tissue (generated locally by the cytoskeleton) or extrinsic and due to an interaction with neighbouring tissues or the environment. Decades of work on different model systems have elucidated the contribution of genetic programs and signalling to morphogenesis; however, the reverse process is not yet well understood. Working jointly between the Baum and Mao labs, and using the Drosophila wing disc as a model system, I aim to reveal how developmental programs respond to and buffer mechanical stresses. 
 

Biography

2018 | PhD Molecular Biology / Biophysics, EMBL Heidelberg, Germany
2014 | MSc Applied Physics, University of Bologna, Italy
2012 | BSc Physics, University of Bologna, Italy 

Awards

2018 | Travel Grant - Heidelberg Graduate Academy 
2017 | Travel Grant - Boehringer Ingelheim Fonds & MBL Physical Biology of the Cell 
2017 | International Travel Award - American Biophysical Society 
2014 | Travel stipend - Dresden Center for Systems Biology
 

Funders

Cancer Research UK

Research Themes

Cytoskeleton, Polarity and cell shape, Signalling pathways, Tissue mechanics

Technology

Light microscopy, Super-resolution microscopy