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Agathe Chaigne's picture

Postdoctoral Fellow, Paluch Lab

a.chaigne@ucl.ac.uk

Europe PMC | PubMed 

Twitter @AgChaigne

Research Synopsis

I am interested in how cells control their shape and sizes and how this is important for cell function. Many cells divide symmetrically but some cells can divide asymmetrically in size generating two cells of different volume. Embryonic stem cells are pluripotent cells that can give rise to the three germ layers. Evidence indicates they can maintain pluripotency whilst giving rise to progenitor cells for all the embryo cells, suggesting that they are capable of asymmetric division. However, the cell biology of embryonic stem cell division is poorly understood. Interestingly, embryonic stem cells have mechanical properties very different from their differentiated counterparts, and their fate is strongly influenced by the mechanical properties of the substrate, suggesting that stem cell division might be asymmetric with respect to daughter cell mechanics. Using live microscopy and microfabrication, I am currently investigating how cell division is regulated in mouse embryonic stem cells.

Biography

2015 | Postdoc (LabeX Memolife), CIRB, Collège de France, Paris
2014 | PhD, CIRB, Collège de France, Paris
 

Awards

2016 | Sir Henry Wellcome Postdoctoral Fellowship
2016 | Human Frontier Science Program Post-Doctoral Fellowship 
2015 | Young researcher prize, Bettencourt-Schueller Foundation
2015 | PhD prize Le Monde de la Recherche Universitaire
2015 | Travel Grant, EMBO workshop
2015 | Lindau Nobel Laureate Meeting alumni
2014 | Student award and poster Prize, “Physics and Biological Systems” meeting
2013 | ITMO BCDE Grant, ASCB Meeting (declined)
2013 | Société de Biologie Cellulaire Française Grant, ASCB Meeting

Funders

Wellcome Trust

Research Themes

Cytoskeleton and cell cortex, Polarity and cell shape

Technology

Light microscopy