Centre for Inflammation and Tissue Repair



Top 5 Publications

Professor Rachel Chambers

1.  mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1–induced collagen biosynthesis. Selvarajah, B., Azuelos, I.,Platé, M, Guillotin, D., Forty, E. J., Contento, G., ... and Chambers R.C. (2019) Science Signaling  21 May 2019: Vol. 12, Issue 582,  eaav3048 DOI: 10.1126/scisignal.aav3048

2. The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis. Woodcock, H. V., Eley, J. D., Guillotin, D., Plate, M., Nanthakumar, C. B., Martufi, M., . . . Chambers, R. C. (2019).  NATURE COMMUNICATIONS, 10, ARTN 6. doi:10.1038/s41467-018-07858-8

3. Acute Respiratory Distress Syndrome. Thompson, B. T., Chambers, R. C., & Liu, K. D. (2017). The New England journal of medicine, 377 (6), 562-572. doi:10.1056/nejmra1608077

4. Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF. Mercer PF, Woodcock HV, Eley JD, Platé M, Sulikowski MG, Durrenberger PF, Franklin L, Nanthakumar CB, Man Y, Genovese F, McAnulty RJ, Yang S, Maher TM, Nicholson AG, Blanchard AD, Marshall RP, Lukey PT, Chambers RC. Thorax 71:701-11, 2016 (doi: 10.1136/thoraxjnl-2015-207429)

5. Evidence for chemokine synergy during neutrophil migration in ARDS. Williams AE, José RJ, Mercer PF, Brealey D, Parekh D, Thickett DR, O'Kane C, McAuley DF, Chambers RC. Thorax 72: 66-73, 2017 (doi: 10.1136/thoraxjnl-2016-208597)

6. Residual Lung Abnormalities Following COVID-19 Hospitalization: Interim Analysis of the UKILD Post-COVID Study. Stewart I, Jacob J, George PM, Molyneaux PL, Porter JC, Allen RJ, Aslani S, Baillie JK, Barratt SL, Beirne P, Bianchi SM, Blaikley JF, Chalmers JD, Chambers RC. American Journal of Respiratory and Critical Care Medicine (2022) (doi:10.1164/rccm.202203-0564OC)

Professor Jerry Brown

1. Naturally Acquired Human Immunity to Pneumococcus Is Dependent on Antibody to Protein Antigens. PLoS Pathogens . Wilson, R., Cohen, J. M., Reglinski, M., Jose, R. J., Chan, W. Y., Marshall, H., . . . Brown, J. S. (2017)., 13(1), e1006137. doi:10.1371/journal.ppat.1006137

2. Changes in the incidence, prevalence and mortality of bronchiectasis in the UK from 2004 to 2013: a population-based cohort study. Quint, J. K., Millett, E. R. C., Joshi, et al . Brown, J. S. (2016).. ERJ, 47(1), 186-193. doi:10.1183/13993003.01033-2015

3. Exposure to welding fumes and lower airway infection with Streptococcus pneumoniae Suri, R., Periselneris, J., Lanone, S., Zeidler-Erdely, P. C., Melton, G., Palmer, K. T., Brown, J. S., Grigg, J. (2016).. JACI, 137(2), 527-+. doi:10.1016/j.jaci.2015.06.033

4. Protection against Streptococcus pneumoniae lung infection after nasopharyngeal colonization requires both humoral and cellular immune responses.Wilson, R., Cohen, J. M., et al, Brown, J. S. (2015). Mucosal Immunol, 8(3), 627-639. doi:10.1038/mi.2014.95

5. TLR-Mediated Inflammatory Responses to Streptococcus pneumoniae Are Highly Dependent on Surface Expression of Bacterial Lipoproteins.Tomlinson, G., Chimalapati, S., et al, E., . . . Brown, J. S. (2014). J Immunol, 193(7), 3736-3745. doi:10.4049/jimmunol.1401413

Professor John Hurst

1. Long-term Triple Therapy De-escalation to Indacaterol/Glycopyrronium in COPD Patients (SUNSET): a Randomized, Double-Blind, Triple-Dummy Clinical Trial. Chapman KR*, Hurst JR* (*joint first author), Frent SM, Larbig M, Fogel R, Guerin T, Banerji D, Patalano F, Goyal P, Pfister P, Kostikas K, Wedzicha JA Am J Respir Crit Care Med. 2018 May 20. doi: 10.1164/rccm.201803-0405OC

2. British Lung Foundation/United Kingdom Primary Immunodeficiency Network Consensus Statement on the Definition, Diagnosis, and Management of Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency Disorders. Hurst JR, Verma N, Lowe D, Baxendale HE, Jolles S, Kelleher P, Longhurst HJ, Patel SY, Renzoni EA, Sander CR, Avery GR, Babar JL, Buckland MS, Burns S, Egner W, Gompels MM, Gordins P, Haddock JA, Hart SP, Hayman GR, Herriot R, Hoyles RK, Huissoon AP, Jacob J, Nicholson AG, Rassl DM, Sargur RB, Savic S, Seneviratne SL, Sheaff M, Vaitla PM, Walters GI, Whitehouse JL, Wright PA, Condliffe AM  J Allergy Clin Immunol Pract. 2017 Jul - Aug;5(4):938-945

3. Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation: A Randomized Clinical Trial.Murphy PB, Rehal S, Arbane G, Bourke S, Calverley PMA, Crook AM, Dowson L, Duffy N, Gibson GJ, Hughes PD, Hurst JR, Lewis KE, Mukherjee R, Nickol A, Oscroft N, Patout M, Pepperell J, Smith I, Stradling JR, Wedzicha JA, Polkey MI, Elliott MW, Hart N.   JAMA. 2017 Jun 6;317(21):2177-2186

4. Cardiovascular risk, myocardial injury, and exacerbations of chronic obstructive pulmonary disease.  Patel AR, Kowlessar BS, Donaldson GC, Mackay AJ, Singh R, George SN, Garcha DS, Wedzicha JA, Hurst JR.  Am J Respir Crit Care Med. 2013 Nov 1;188(9):1091-9

5. Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators.  Susceptibility to exacerbation in chronic obstructive pulmonary disease. Hurst JR, Vestbo J, Anzueto A, Locantore N, Müllerova H, Tal-Singer R, Miller B, Lomas DA, Agusti A, Macnee W, Calverley P, Rennard S, Wouters EF, Wedzicha JA; Evaluation of COPD  N Engl J Med. 2010 Sep 16;363(12):1128-38

Professor Robin McAnulty

1. Effective silencing of ENaC by siRNA delivered with epithelial-targeted nanocomplexes in human cystic fibrosis cells and in mouse lung. Tagalakis AD, Munye MM, Ivanova R, Chen H, Smith CM, Aldossary AM, Rosa LZ, Moulding D, Barnes JL, Kafetzis KN, Jones SA, Baines DL, Moss GWJ, O'Callaghan C, McAnulty RJ, Hart SL.Thorax. 2018 May 10. pii: thoraxjnl-2017-210670. doi: 10.1136/thoraxjnl-2017-210670. [Epub ahead of print]

2. Diverse functions of clusterin promote and protect against the development of pulmonary fibrosis. Peix L, Evans IC, Pearce DR, Simpson JK, Maher TM, McAnulty RJ. Sci Rep. 2018 Jan 30;8(1):1906. doi: 10.1038/s41598-018-20316-1.

3. Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study. Allen RJ, Porte J, Braybrooke R, Flores C, Fingerlin TE, Oldham JM, Guillen-Guio B, Ma SF, Okamoto T, John AE, Obeidat M, Yang IV, Henry A, Hubbard RB, Navaratnam V, Saini G, Thompson N, Booth HL, Hart SP, Hill MR, Hirani N, Maher TM, McAnulty RJ, Millar AB, Molyneaux PL, Parfrey H, Rassl DM, Whyte MKB, Fahy WA, Marshall RP, Oballa E, Bossé Y, Nickle DC, Sin DD, Timens W, Shrine N, Sayers I, Hall IP, Noth I, Schwartz DA, Tobin MD, Wain LV, Jenkins RG. Lancet Respir Med. 2017 Nov;5(11):869-880. doi: 10.1016/S2213-2600(17)30387-9. Epub 2017 Oct 20.

4. Caffeine inhibits TGFβ activation in epithelial cells, interrupts fibroblast responses to TGFβ, and reduces established fibrosis in ex vivo precision-cut lung slices. Tatler AL, Barnes J, Habgood A, Goodwin A, McAnulty RJ, Jenkins G. Thorax. 2016 Jun;71(6):565-7. doi: 10.1136/thoraxjnl-2015-208215. Epub 2016 Feb 24.

5. Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis.

Evans IC, Barnes JL, Garner IM, Pearce DR, Maher TM, Shiwen X, Renzoni EA, Wells AU, Denton CP, Laurent GJ, Abraham DJ, McAnulty RJ. Clin Sci (Lond). 2016 Apr;130(8):575-86. doi: 10.1042/CS20150697. Epub 2016 Jan 7.

Professor Jo Porter

1. Platelets Regulate Pulmonary Inflammation and Tissue Destruction in Tuberculosis. Fox KA, Kirwan DE, Whittington AM, Krishnan N, Robertson BD, Gilman RH, López JW, Singh S, Porter JC, Friedland JS Am J Respir Crit Care Med. 2018 Feb 8. doi: 10.1164/rccm.201710-2102OC.

2. Pulmonary 18F-FDG uptake helps refine current risk stratification in idiopathic pulmonary fibrosis (IPF).  Win T, Screaton NJ, Porter JC, Ganeshan B, Maher TM, Fraioli F, Endozo R, Shortman RI, Hurrell L, Holman BF et al. Eur J Nucl Med Mol Imaging. 2018 May;45(5):806-815. doi: 10.1007/s00259-017-3917-8. Epub 2018 Jan 16. 

3. Update in diagnosis and management of interstitial lung disease. Mikolasch, T. A., Garthwaite, H. S., & Porter, J. C. Clin Med (Lond). 2016 Dec;16(Suppl 6):s71-s78. Review.

4. Prevalence and risk factors of restrictive spirometry in a cohort of Peruvian adults. Siddharthan T, Grigsby M, Miele CH, Bernabe-Ortiz A, Miranda JJ, Gilman RH, Wise RA, Porter JC, Hurst JR, Checkley W The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Int J Tuberc Lung Dis. 2017 Sep 1;21(9):1062-1068. doi: 10.5588/ijtld.17.0101. 

5. Monocyte Adhesion, Migration, and Extracellular Matrix Breakdown Is Regulated by Integrin αVβ3 in Mycobacterium tuberculosis Infection. Brilha, S., Wysoczanski, R., Whittington, A. M., Friedland, J. S., & Porter, J. C. J Immunol. 2017 Aug 1;199(3):982-991. doi: 10.4049/jimmunol.1700128. Epub 2017 Jun 23.