Royal Free HIV Cohort Study

Project Summary

The Royal Free HIV Cohort Study (RFHCS) is an ongoing prospective study of individuals attending the Royal Free Hospital, London, UK for HIV care. It addresses research questions relating to diagnosis, treatment, prognosis, management and experience of individuals living with HIV. Over 7000 individuals are included.

The RFHCS was started in the early 1990s and has contributed to understanding of HIV outcomes, including the prognostic value of laboratory markers such as CD4 count, trends over time in treatment outcomes, effectiveness and durability of treatments in a real life setting, treatment adherence and adverse events, the impact of gender, ethnicity and socioeconomic factors on HIV outcomes, the utility of treatment in acute HIV, and outcomes for people with comorbidities such as tuberculosis and hepatitis.

The RFHCS is also part of several collaborative national and international studies including the UK Collaborative HIV Cohort (CHIC) and the Antiretroviral Cohort Collaboration (ART-CC).

Key Project Information

Dates: 1991 - (ongoing)

UCL lead/Principal Investigator: Dr Fiona Lampe/Dr Colette Smith

Lead organisation: UCL

Partners: Royal Free NHS Foundation Trust, HIV services

Location: UK

Funding: Royal Free Charity

Contact: f.lampe@ucl.ac.uk and c.smith@ucl.ac.uk

Research Team

Clinical: T Barber, S Bhagani, F Burns, A Carroll, I Cropley, T Fernandez, M Johnson, A Katiyar, D Levitt, S Kinloch-de Loes, M Lipman, S Madge, T Mahangu, G Murphy, M Panchal, A Rodger, R Shah, L Swaden, A Wright, M Youle

Data management: C Chaloner, A Hunter, R Tsintas

Epidemiology/Biostatistics: F Lampe, A Phillips, S Rein, C Smith, A Speakman

Laboratory: M Connell, G Clewley, S Martin

Collaborations

UK CHIC

UK HIV Drug Resistance Database

CASCADE

ART Cohort Collaboration