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Project Summary
The HIV BioResource builds on the existing Cambridge and UCL BioResource, and forms part of the National NIHR BioResource.
The NIHR BioResource is a collaboration between five Biomedical Research Centres (UCL, Imperial, Kings/IoP, Oxford and Cambridge) and one Biomedical Research Unit (Leicester) to establish a federated database of healthy individuals and patients with neurological, cardiovascular, or infectious/inflammatory or immune disorders, or with rare diseases, who are consented for recall for research on the basis of genotype or phenotype.
The aim of the NIHR BioResource is to build on and integrate existing resources to promote recruitment of well genotyped and phenotyped participants into local studies coordinated through existing Clinical Research Facilities within NIHR Biomedical Research Units and Centres.
The HIV BioResource study contributes to this national endeavour through local recruitment of up to 10,000 patients from HIV cohorts at affiliated hospitals. The HIV BioResource collects and stores blood samples and derivatives including DNA from the individuals.
The HIV BioResource will take advantage of links with the UK Collaborative HIV Cohort Study (UK CHIC) and the UK HIV Drug Resistance Database (UK HDRD), which together represent two of the largest and most productive HIV cohort studies/databases in the world, to explore host genetic predictors/correlates with a range of clinical and virological phenotypes.