Institute for Global Health


UCL Centre for Clinical Research, Epidemiology, Modelling and Evaluation (CREME)

The Centre for Clinical Research, Epidemiology, Modelling and Evaluation applies multi-disciplinary research methods to generate an in-depth understanding of problems and their solutions in order to inform improvements in population health and guide policy.  For several years this has largely been based around studies of risk of HIV acquisition, studies of people living with HIV, and models of HIV transmission, progression and the effect of ART to inform policy in high, middle and low-income settings.  Recently, research has expanded into other infections and chronic conditions.  We work closely with national and international policy making bodies such as Public Health England and the World Health Organisation.  The Centre also organises the International Workshop on HIV and Hepatitis Observational Databases (IWHOD) annually.

Strategic Priorities

  • To undertake research to understand mechanistic pathways of disease, variations in prognosis and complications of disease and/or its treatment, with the aim of improving health outcomes
  • To create a greater understanding of the impact of social, structural and clinical  factors on the evolution of disease epidemics
  • To use mathematical modelling to understand the health and economic impact of public health interventions, with the aim of contributing to policy decision-making processes·
  • To undertake evaluation of programmes, interventions and innovative models of health care delivery.

See a full list of our research projects