International Centre for Genomic Medicine in Neuromuscular Diseases


NIMS, Hyderabad

Nizam’s Institute of Medical Sciences

Department of Neurology, Hyderabad,Telangana,India.




Centre Principal Investigator and ICGNMD Faculty PI:

Dr Sireesha Yareeda MD,DM.

Dr Sireesha Yareeda

Nizams External View


Clinical neuromuscular expertise, patients and geographical region:

Our Centre is well equipped in the management of patients with neuromuscular disorders with a sophisticated electrophysiology laboratory and skilled neurophysiologists.

The hospital is located in Hyderabad, one of the fastest growing cities of India, and is well connected with other Indian states and the world. NIMS hosts one of India's biggest neurology departments: 200-300 patients attend the outpatient clinic every day. This includes a very large number of referrals for neuromuscular diseases. Patients are followed up longitudinally and are given multidisciplinary neuromuscular care encompassing genetic counselling, cardiac and respiratory monitoring and rehabilitative services.

We are gifted with an experienced radiologist to perform high resolution ultrasound of nerve and muscle in certain complicated cases. Our Center is the first in India to have performed large number of magnetic resonance neurograms (MRN) initiated by our beloved Professor Meena Angamuthu Kanikannan.

Current research programmes:

We are actively engaged in clinical trials on children with ataxia telangiectasia, Duchenne /Becker muscular dystrophy and multiple sclerosis.

We are working on mitochondrial spectrum disorders in addition to the ongoing registries on Guillain Barre syndrome, myasthenia gravis and neuropathies.

Recent significant publications:

1.Sireesha Y, Kanikannan MA, Pyal A, Sandeep G, Uppin MS, Kandadai RM, Jabeen SA, Varaprasad R, Rajasekhar L, Neeharika ML, Borgohain R. Patterns of peripheral neuropathy in Sjogren's syndrome in a tertiary care hospital from South India. Neurol India. 2019 Jan-Feb;67(Supplement):S94-S99. doi: 10.4103/0028-3886.250714. PMID: 30688241.

2. A series of biopsy proven patients with Ig G4 related neurological disease. Citation: Sireesha Y, Uppin MS, Ganti S, Alugolu R, Mudumba VS, Bhattacharjee S,  Neeharika ML, Bastia J, Kanikannan MA. A Series of Biopsy-proven Patients with  Immunoglobulin G4-related Neurological Disease. Ann Indian Acad Neurol. 2019 Jan Mar;22(1):73-78. doi: 10.4103/aian.AIAN_283_18. PMID: 30692763; PMCID:  PMC6327705.

3.  Hui M, Meena AK, Rajasekhar L, Sireesha Y, Afshan J, Mridula R, Borgohain R,  Uppin MS. Vasculitic Neuropathy: A Retrospective Analysis of Nerve Biopsies and Clinical  Features from a Single Tertiary Care Center. Ann Indian Acad Neurol. 2019 Apr Jun;22(2):180-186. doi: 10.4103/aian.AIAN_47_18. PMID: 31007430; PMCID: PMC6472243.

4.  Sireesha Y, Uppin MS, Bohra K, Alugolu R, Neeharika ML, Kanikannan A.  Longitudinally Extensive Transverse Myelitis Due to Toxoplasma: An Autopsy  Study. Ann Indian Acad Neurol. 2018;21(2):161-163. doi:10.4103/aian.AIAN_387_17

5. Kanikannan, M., Sirisha, Y., Uppin, M., Jabeen, S., Kandadai, R., Sundaram, C., Raghunadharao, D., & Borgohain, R. (2015). Incidence and spectrum of paraneoplastic neurological syndromes: single center study. Journal of Neuro-Oncology, 125(1), 197-206.


How the ICGNMD will benefit research and clinical programmes

The collaboration between Nizam’s Institute of Medical Sciences (NIMS) and ICGNMD is expected to further stream line  the phenotypic and genetic data bases of patients with neuromuscular diseases.These would open  windows for diagnostic and therapeutic research and are expected to modify the  management of  genetic neuromuscular disorders and their application to the bedside.