Institute of Epidemiology & Health Care


Silent Ischemia Study

The Silent Ischemia Study (SIS) was an investigation of emotional and behavioural factors influencing biological regulation and myocardial function in patients with coronary artery disease. The study involved patients with suspected or confirmed coronary artery disease-carrying out 24-hour ECG (Holter) monitoring, together with measures of physical activity and salivary cortisol. After the monitoring period, patients completed the day reconstruction interview. Patients were followed up at 6 months.

The study was funded through a programme grant from the British Heart Foundation. 

Principal Investigator: Professor Andrew Steptoe 

Contact: Professor Andrew Steptoe (a.steptoe@ucl.ac.uk)

Collaborators: Dr Roby Rakhit (Royal Free Hospital)