allergy-exemplar

EXEMPLAR PROJECTS

Induction of human allergen-specific immune regulation: TLR-7 agonist with allergen

EMINENT News

February 2019

The Allergen-specific immune regulation by TLR7 agonist project recently demonstrated that Type 2 allergen specific hyporesponsiveness could be obtained by combining allergen challenge with a unique GSK TLR7 agonist ex vivo and thereby provided sufficient POC to permit planning of a DBPC clinical trial with use of nasal allergen challenge as primary endpoint in allergic rhinitis. Further work will now be pursued with follow-on funding outside EMINENT.