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COVID-19 Longitudinal Health and Wellbeing National Core Study

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COVID-19 Longitudinal Health and Wellbeing National Core Study

Mental Health

Mental Health

Living alone and mental health: parallel analyses in UK longitudinal population surveys and electronic health records prior to and during the COVID-19 pandemic

Eoin McElroy, Emily Herrett,  Kishan Patel,  Dominik M Piehlmaier,  Giorgio Di Gessa , Charlotte Huggins, Michael J Green, Alex S F Kwong,  Ellen J Thompson,  Jingmin Zhu, Kathryn E Mansfield,  Richard J Silverwood, Rosie Mansfield, Jane Maddock,  Rohini Mathur,  Ruth E Costello, Anthony Matthews,  John Tazare, Alasdair Henderson,  Kevin Wing,  Lucy Bridges, Sebastian Bacon,  Amir Mehrkar , OpenSAFELY Collaborative, Richard John Shaw,  Jacques Wels,  Srinivasa Vittal Katikireddi,  Nish Chaturvedi, Laurie A Tomlinson, Praveetha Patalay, on behalf of the Longitudinal Health and Wellbeing Collaborative Full text

Psychological distress, depression, anxiety, and life satisfaction following COVID-19 Infection: Evidence from 11 UK longitudinal population studies

Ellen J. Thompson, Jean Stafford, Bettina Moltrecht ,  Charlotte F. Huggins, Alex S. F. Kwong, Richard J. Shaw, Paola Zaninotto, Kishan Patel, Richard J. Silverwood, Eoin McElroy, Matthias Pierce, Michael J. Green,  Ruth C. E. Bowyer, Jane Maddock, Kate Tilling, S. Vittal Katikireddi,  George B. Ploubidis, David J. Porteous,  Nic Timpson,  Nish Chaturvedi, Claire J. Steves,  Praveetha Patalay Full Text

Association between home working and mental health by key worker status during the Covid-19 pandemic. Evidence from four British longitudinal studies

Bozena Wielgoszewska, Charlotte Booth, Michael J Green, Olivia KL Hamilton, Jacques Wels Full Text  

Psychological Distress Before and During the COVID-19 Pandemic: Sociodemographic Inequalities in 11 UK Longitudinal Studies                               

Kishan Patel, Elaine Robertson, Alex S. F. Kwong , Gareth J Griffith, Kathryn Willan, Michael J Green, Giorgio Di Gessa, Charlotte F. Huggins, Eoin McElroy, Ellen J. Thompson , Jane Maddock, Claire L Niedzwiedz, Morag Henderson, Marcus Richards, Andrew Steptoe, George B. Ploubidis, Bettina Moltrecht, Charlotte Booth, Emla Fitzsimons, Richard Silverwood, Praveetha Patalay, David Porteous, Srinivasa Vittal Katikireddi  Full Text

Pre-pandemic mental health and disruptions to healthcare, economic, and housing outcomes during COVID –19: evidence from 12 UK longitudinal studies

Giorgio Di Gessa, Jane Maddock, Michael J. Green, Ellen J. Thompson, Eoin McElroy, Helena L. Davies, Jessica Mundy, Anna J. Stevenson, Alex S.F. Kwong, Gareth J. Griffith, Srinivasa Vittal Katikireddi, Claire L. Niedzwiedz, George B. Ploubidis, Emla Fitzsimons, Morag Henderson, Richard J. Silverwood, Nish Chaturvedi, Gerome Breen, Claire J. Steves, Andrew Steptoe, David J Porteous, Praveetha Patalay  Full Text

Mental health in relation to changes in sleep, exercise, alcohol and diet during the COVID-19 pandemic: examination of four UK cohort studies

Aase Villadsen, Praveetha Patalay and David Bann Full Text

 

Mental health before and during the COVID-19 pandemic in two longitudinal UK population cohorts

Alex S. F. Kwong, Rebecca M. Pearson, Mark J. Adams, Kate Northstone, Kate Tilling, Daniel Smith, Chloe Fawns-Ritchie, Helen Bould, Naomi Warne, Stanley Zammit, David J. Gunnell, Paul A. Moran, Nadia Micali, Abraham Reichenberg, Matthew Hickman, Dheeraj Rai, Simon Haworth, Archie Campbell, Drew Altschul, Robin Flaig, Andrew M. McIntosh, Deborah A. Lawlor, David Porteous and Nicholas J. Timpson Full Text

Healthcare Disruption

Healthcare Disruption

Trends in inequalities in avoidable hospitalisations across the COVID-19 pandemic: a cohort study of 23.5 million people in England

Mark Alan Green , Martin McKee, Jon Massey, Brian Mackenna, Amir Mehrkar, Seb Bacon, John Macleod, Aziz Sheikh, Syed Ahmar Shah , The OpenSAFELY Consortium, The Longitudinal Health and Wellbeing National Core Study Collaborative, Srinivasa Vittal Katikireddi  full text

Associations between self-reported healthcare disruption due to covid-19 and avoidable hospital admission: evidence from seven linked longitudinal studies for England

Mark A Green, Martin McKee, Olivia KL Hamilton, Richard J Shaw, John Macleod, Andy Boyd, Srinivasa Vittal Katikireddi full text

Health care use attributable to COVID-19: A propensity matched national electronic health records cohort study of 249,390 people in Wales, UK

J Kennedy, M Parker, M Seaborne, M Mhereeg, A Walker, V Walker, S Denaxas, N KennedyS.V Katikireddi, S Brophy full text

Ethnic differences in the indirect impacts of the COVID-19 pandemic on clinical monitoring and hospitalisations for non-COVID conditions in England: An observational cohort study using OpenSAFELY

Ruth E Costello, John Tazare,  Dominik Piehlmaier,  Emily Herrett,  Edward PK Parker,  Bang Zheng,  Kathryn E Mansfield,  Alasdair D Henderson, Helena Carreira,  Patrick Bidulka, Angel YS Wong,  Charlotte Warren-Gash, Joseph F Hayes,    Jennifer K Quint,   Brian MacKenna,   Rosalind M Eggo,  Srinivasa Vittal Katikireddi,   Laurie Tomlinson, Sinéad M Langan,  Rohini Mathur, the longitudinal health and wellbeing collaborative and the OpenSAFELYcollaborative  full text  

Healthcare in England was affected by the COVID-19 pandemic across the pancreatic cancer pathway: a cohort study using OpenSAFELY-TPP

Agnieszka Lemanska, Colm Andrews, Louis Fisher, Seb Bacon, Amir Mehrkar, Peter Inglesby, Simon Davy, Praveetha Patalay, Ben Goldacre, Brian MacKenna, The OpenSAFELY Collaborative, Alex Walker  full text

The Impact of the COVID-19 pandemic on prescribing pancreatic enzyme replacement therapy for people with unresectable pancreatic cancer in England. A cohort study using OpenSafely-TPP

Agnieszka Lemanska, Colm Andrews, Louis Fisher, Ben Butler-Cole, Amir Mehrkar, Keith J Roberts, Ben Goldacre, Alex J Walker, The OpenSAFELY Collaborative, Brian MacKenna full text

OpenSAFELY NHS Service Restoration Observatory 2: changes in primary care activity across six clinical areas during the COVID-19 pandemic

 Helen J Curtis, Brian MacKenna, Milan Wiedemann, Louis Fisher, Richard Croker, Caroline E Morton , Peter Inglesby, Alex J Walker, Jessica Morley, Amir Mehrkar, Sebastian CJ Bacon, George Hickman, David Evans, Tom Ward, Simon Davy, William J Hulme, Orla Macdonald, Robin Conibere, Tom Lewis, Martin Myers, Shamila Wanninayake, Kiren Collison, Charles Drury, Miriam Samuel, Harpreet Sood, Andrea Cipriani, Seena Fazel, Manuj Sharma, Wasim Baqir , Chris Bates, John Parry, Ben Goldacre  full text

Changes in English medication safety indicators throughout the COVID-19 pandemic: a federated analysis of 57 million patients’ primary care records in situ using OpenSAFELY

Louis Fisher, Lisa E. M. Hopcroft, Sarah Rodgers, James Barrett, Kerry Oliver, Anthony J. Avery, Dai Evans, Helen Curtis, Richard Croker, Orla Macdonald, Jessica Morley, Amir Mehrkar, Seb Bacon, Simon Davy, Iain Dillingham, David Evans, George Hickman, Peter Inglesby, Caroline E. Morton, Becky Smith, Tom Ward, William Hulme, Amelia Green, Jon Massey, Alex J. Walker, Chris Bates, Jonathan Cockburn, John Parry, Frank Hester, Sam Harper, Shaun O’Hanlon, Alex Eavis, Richard Jarvis, Dima Avramov, Paul Griffiths, Aaron Fowles, Nasreen Parkes, Ben Goldacre, Brian MacKenna Full Text

Impact of First UK COVID-19 Lockdown on Hospital Admissions: Interrupted Time Series Study of 32 Million People

Syed Ahmar Shah, Sinead Brophy, John Kennedy, Louis Fisher, Alex Walker, Brian Mackenna, Helen Curtis, Peter Inglesby, Simon Davy, Seb Bacon , Ben Goldacre, OpenSAFELY Collaborative, Utkarsh Agrawal, Emily Moore, Colin R Simpson, John Macleod, Roxane Cooksey, Aziz Sheikh and Srinivasa Vittal Katikireddi Full Text

Population birth outcomes in 2020 and experiences of expectant mothers during the COVID-19 pandemic: a ‘Born in Wales’ mixed methods study using routine data

Hope Jones, Mike Seaborne, Laura Cowley, David Odd, Shantini Paranjothy, Ashley Akbari, Sinead Brophy Full Text   

Inequalities in healthcare disruptions during the Covid-19 pandemic: Evidence from 12 UK population-based longitudinal studies

Jane Maddock, Sam Parsons, Giorgio Di Gessa, Michael J. Green, Ellen J. Thompson, Anna J. Stevenson, Alex S.F. Kwong, Eoin McElroy, Gillian Santorelli, Richard J. Silverwood, Gabriella Captur, Nish Chaturvedi, Claire J. Steves, Andrew Steptoe, Praveetha Patalay, George B. Ploubidis, Srinivasa Vittal Katikireddi Full Text

Impact of COVID-19 pandemic on asthma exacerbations: Retrospective cohort study of over 500,000 patients in anational English primary care database

Syed Ahmar Shah, Jennifer K Quint, Aziz Sheikh full text

 

Impact on emergency and elective hospital-based care in Scotland over the first 12 months of the pandemic: interrupted time-series analysis of national lockdowns

Syed Ahmar Shah, Rachel H Mulholland, Samantha Wilkinson, Srinivasa Vittal Katikireddi, Jiafeng Pan, Ting Shi, Steven Kerr, Uktarsh Agrawal, Igor Rudan, Colin R Simpson, Sarah J Stock , John Macleod , Josephine-LK Murray , Colin McCowan, Lewis Ritchie , Mark Woolhouse and Aziz Sheikh Full Text

Remote general practitioner consultations during COVID-19

Mark A Green, Martin McKee, Srinivasa Vittal Katikireddi Full Text

Association between warfarin and COVID-19-related outcomes compared with direct oral anticoagulants: population-based cohort study

The OpenSAFELY Collaborative, Angel Y. S. Wong, Laurie A. Tomlinson, Jeremy P. Brown, William Elson, Alex J. Walker, Anna Schultze, Caroline E. Morton, David Evans, Peter Inglesby , Brian MacKenna, Krishnan Bhaskaran, Christopher T. Rentsch, Emma Powell, Elizabeth Williamson , Richard Croker, Seb Bacon, William Hulme, Chris Bates, Helen J. Curtis, Amir Mehrkar, Jonathan Cockburn, Helen I. McDonald, Rohini Mathur, Kevin Wing, Harriet Forbes, Rosalind M. Eggo, Stephen J. W. Evans, Liam Smeeth, Ben Goldacre and Ian J. Douglas Full Text

Society and Health

Home working and social and mental wellbeing at different stages of the COVID-19 pandemic in the UK: Evidence from 7 longitudinal population surveys

Jacques Wels, Bożena Wielgoszewska, Bettina Moltrecht, Charlotte Booth, Michael J. Green, Olivia KL Hamilton, Evangelia Demou, Giorgio Di Gessa, Charlotte Huggins, Jingmin Zhu, Gillian Santorelli , Richard J. Silverwood, Daniel Kopasker , Richard J. Shaw, Alun Hughes, Praveetha Patalay, Claire Steves, Nishi Chaturvedi, David J. Porteous, Rebecca Rhead, Srinivasa Vittal Katikireddi, George B. Ploubidis full text

Association between home working and mental health by key worker status during the Covid-19 pandemic. Evidence from four British longitudinal studies

Bożena Wielgoszewska, Charlotte Booth, Michael J Green, Olivia KL Hamilton, Jacques Wels Full Text

The UK COVID-19 furlough scheme and associations with smoking, alcohol consumption and vaping: evidence from 8 UK longitudinal population surveys

Michael J. Green,  Jane Maddock, Giorgio Di Gessa, Bożena Wielgoszewska, Sam Parsons, Gareth J Griffith,  Jazz Croft, Anna J. Stevenson, Charlotte F. Huggins, Charlotte Booth, Jacques Wels,  Richard J. Silverwood,  Praveetha Patalay, Alun D. Hughes,  Nishi Chaturvedi, Laura D Howe,  Emla Fitzsimons,  Srinivasa Vittal Katikireddi, George B. Ploubidis Full Text

Mental and social wellbeing and the UK coronavirus job retention scheme: Evidence from nine longitudinal studies

Jacques Wels, Charlotte Booth, Bożena Wielgoszewska, Michael J. Green, Giorgio Di Gessa, Charlotte F. Huggins, Gareth J. Griffith, Alex S. F. Kwong, Ruth C. E. Bowyer, Jane Maddock, Praveetha Patalay, Richard J. Silverwood, Emla Fitzsimons, Richard J. Shaw, Ellen Thompson, Andrew Steptoe, Alun Hughes, Nishi Chaturvedi, Claire J. Steves, Srinivasa Vittal Katikireddi, George B. Ploubidis Full Text

The UK Coronavirus Job Retention Scheme and changes in diet, physical activity and sleep during the COVID-19 pandemic: Evidence from eight longitudinal studies    

Bożena Wielgoszewska, Jane Maddock, Michael J. Green, Giorgio Di Gessa, Sam Parsons, Gareth J Griffith, Jazz Croft, Anna J. Stevenson, Charlotte Booth, Richard J. Silverwood, David Bann, Praveetha Patalay, Alun D. Hughes, Nishi Chaturvedi, Laura D Howe, Emla Fitzsimons, Srinivasa Vittal Katikireddi, George B. Ploubidis Full Text

Vaccination

Vaccination

Challenges in estimating the effectiveness of 2 doses of COVID-19 vaccine beyond 6 months in England

Elsie M. F. Horne, William J. Hulme, Ruth H. Keogh, Tom M. Palmer, Elizabeth J. Williamson, Edward P. K. Parker, Venexia M. Walker, Rochelle Knight, Yinghui Wei, Kurt Taylor, Louis Fisher, Jessica Morley, Amir Mehrkar, Iain Dillingham, Sebastian Bacon, Ben Goldacre2and Jonathan A. C. Sterne for the OpenSAFELY Collaborative full text

Comparative effectiveness of two- and three-dose schedules involving AZD1222 and BNT162b2 in people with kidney disease: a linked OpenSAFELY and UK Renal Registry cohort study

The OpenSAFELY Collaborative,  Edward PK Parker,    Elsie MF Horne, William J Hulme,  John Tazare,  Bang Zheng,  Edward J Carr, Fiona Loud, Susan Lyon, Viyaasan Mahalingasivam,  Brian MacKenna,   Amir Mehrkar, Miranda Scanlon, Shalini Santhakumaran, Retha Steenkamp, Ben Goldacre,  Jonathan AC Sterne, Dorothea Nitsch, Laurie A Tomlinson, The LH&W NCS (or CONVALESCENCE) Collaborative full text

COVID-19 vaccination in pregnancy: views and vaccination uptake rates in pregnancy, a mixed methods analysis from the Born In Wales study

M Mhereeg, H Jones, J Kennedy, M Seaborne, M Parker, N Kennedy, S Beeson, L Zuccolo, A Davies, S Brophy full text

Comparative effectiveness of BNT162b2 versus mRNA-1273 boosting in England: a cohort study in OpenSAFELY-TPP

William J Hulme,  Elsie MF Horne,  Edward PK Parker,  Ruth H Keogh,  Elizabeth J Williamson, Venexia Walker, Tom Palmer,  Helen J Curtis, Alex Walker, Amir Mehrkar,  Jessica Morley, Brian MacKenna,  Sebastian CJ Bacon,  Ben Goldacre,   Miguel A Hernán,   Jonathan AC Sterne, the OpenSAFELY collaborative  full text

Risk of myocarditis and pericarditis following BNT162b2 and ChAdOx1 COVID-19 vaccinations

Samantha Ip, Fatemeh Torabi, Spiros Denaxas, Ashley Akbari, Rochelle Knight, Jennifer Cooper, Rachel Denholm, Spencer Keene, Thomas Bolton, Sam Hollings, Efosa Omigie Teri-Louise North, Arun Karthikeyan Suseeladevi, Emanuele Di Angelantonio, Kamlesh Khunti, Jonathan A C Sterne, Cathie Sudlow, William Whiteley, Angela Wood, Venexia Walker full text

Factors associated with COVID-19 vaccine uptake in people with kidney disease: an OpenSAFELY cohort study 

 Edward PK Parker, John Tazare, William J Hulme2 , Christopher Bates, Rupert Beale, Edward J Carr, Jonathan Cockburn, Helen J Curtis, Louis Fisher, Amelia CA Green, Sam Harper, Frank Hester, Elsie MF Horne, Fiona Loud, Susan Lyon, Viyaasan Mahalingasivam, Amir Mehrkar, Linda Nab, John Parry, Shalini Santhakumaran, Retha Steenkamp, Jonathan AC Sterne, Alex J Walker, Elizabeth J Williamson, Michelle Willicombe, Bang Zheng, Ben Goldacre, Dorothea Nitsch, Laurie A Tomlinson Full text

Comparative effectiveness of ChAdOx1 versus BNT162b2 COVID-19 vaccines in Health and Social Care workers in England: a cohort study using OpenSAFELY

William J Hulme, Elizabeth J Williamson, Amelia Green, Krishnan Bhaskaran, Helen I McDonald, Christopher T Rentsch, Anna Schultze, John Tazare, Helen J Curtis, Alex J Walker, Laurie Tomlinson, Tom Palmer, Elsie Horne, Brian MacKenna, Caroline E Morton, Amir Mehrkar, Louis Fisher, Seb Bacon, Dave Evans, Peter Inglesby, George Hickman, Simon Davy, Tom Ward, Richard Croker, Rosalind M Eggo, Angel YS Wong, Rohini Mathur, Kevin Wing, Harriet Forbes, Daniel Grint, Ian J Douglas, Stephen JW Evans, Liam Smeeth, Chris Bates, Jonathan Cockburn, John Parry, Frank Hester, Sam Harper, Jonathan AC Sterne, Miguel Hernán, Ben Goldacre Full Text

Antibody levels following vaccination against SARSCoV-2: associations with post-vaccination infection and risk factors

Nathan J. Cheetham, Milla Kibble, Andrew Wong, Richard J. Silverwood, Anika Knuppel, Dylan M. Williams, Olivia K. L. Hamilton, Paul H. Lee, Charis Bridger Staatz, Giorgio Di Gessa, Jingmin Zhu, Srinivasa Vittal Katikireddi, George B. Ploubidis, Ellen J. Thompson, Ruth C. E. Bowyer, Xinyuan Zhang, Golboo Abbasian, Maria Paz Garcia, Deborah Hart, Jeffrey Seow, Carl Graham, Neophytos Kouphou, Sam Acors, Michael H. Malim, Ruth E. Mitchell, Kate Northstone, Daniel Major-Smith, Sarah Matthews, Thomas Breeze, Michael Crawford, Lynn Molloy, Alex S. F. Kwong, Katie J. Doores, Nishi Chaturved, Emma L. Duncan, Nicholas J. Timpson, Claire J. Steves  full text

Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, and thrombocytopenic events: whole population cohort study in 46 million adults in England

CVD-COVID-UK consortium, William N Whiteley, Samantha Ip, Jennifer A Cooper, Thomas Bolton, Spencer Keene, Venexia Walker,Rachel Denholm, Akbari, Efosa Omigie, Sam Hollings, Emanuele Di Angelantonio, Spiros Denaxas, Angela Wood, Jonathan A C Sterne, Cathie Sudlow Full Text

Recording of “COVID-19 vaccine declined” among vaccination priority groups: a cohort study on 57.9 million NHS patients’ primary care records in situ using OpenSAFELY

Helen J Curtis, Peter Inglesby, Brian MacKenna, Richard Croker, William Hulme, Christopher T Rentsch, Krishnan Bhaskaran, Alex J Walker, Caroline E Morton, David Evans, Amir Mehrkar, Seb Bacon, Chris Bates, George Hickman, Tom Ward, Jessica Morley, Jonathan Cockburn, Simon Davy, Anna Schultze, Elizabeth Williamson, Helen I McDonald, Laurie Tomlinson, Rohini Mathur, Rosalind M Eggo, Kevin Wing, Angel YS Wong, Harriet Forbes, John Tazare, John Parry, Frank Hester, Sam Harper, Shaun O’Hanlon, Alex Eavis, Richard Jarvis, Dima Avramov, Paul Griffiths, Aaron Fowles, Nasreen Parkes, Stephen JW Evans, Ian J Douglas, Liam Smeeth, Ben Goldacre Full Text

Describing the population experiencing COVID-19 vaccine breakthrough following second vaccination in England: A cohort study from OpenSAFELY The OpenSAFELY Collaborative

 Amelia Green, Helen Curtis, William Hulme , Elizabeth Williamson, Helen McDonald, Krishnan Bhaskaran, Christopher Rentsch, Anna Schultze, Brian MacKenna, Viyaasan Mahalingasivam, Laurie Tomlinson, Alex Walker, Louis Fisher, Jon Massey, Colm Andrews, Lisa Hopcroft, Caroline Morton, Richard Croker, Jessica Morley, Amir Mehrkar, Seb Bacon, David Evans, Peter Inglesby, George Hickman, Tom Ward, Simon Davy, Rohini Mathur, John Tazare, Rosalind M Eggo, Kevin Wing, Angel Wong, Harriet Forbes, Chris Bates, Jonathan Cockburn, John Parry, Frank Hester, Sam Harper, Ian Douglas, Stephen Evans, Liam Smeeth, Ben Goldacre Full Text

Understanding COVID-19 trajectories from a nationwide linked electronic health record cohort of 56 million people: phenotypes, severity, waves & vaccination

Johan H Thygesen, Christopher Tomlinson, Sam Hollings, Mehrdad Mizani, Alex Handy, Ashley Akbari, Amitava Banerjee, Jennifer Cooper, Alvina Lai, Ken Li, Bilal Mateen, Naveed Sattar, Reecha Sofat, Ana Torralbo, Honghan Wu, Angela Wood, Jonathan A C Sterne, Christina Pagel, William Whiteley, Cathie Sudlow, Harry Hemingway, Spiros Denaxas , on behalf of the CVD-COVID-UK Consortium Full Text

Waning effectiveness of BNT162b2 and ChAdOx1 covid-19 vaccines over six months since second dose: OpenSAFELY cohort study using linked electronic health records

Elsie MF Horne, William J Hulme, Ruth H Keogh, Tom M Palmer, Elizabeth J Williamson, Edward PK Parker, Amelia Green, Venexia Walker, Alex J Walker, Helen Curtis, Louis Fisher, Brian MacKenna, Richard Croker, Lisa Hopcroft, Robin Y Park, Jon Massey, Jessica Morley, Amir Mehrkar, Sebastian Bacon, David Evans, Peter Inglesby, Caroline E Morton, George Hickman, Simon Davy, Tom Ward, Iain Dillingham, Ben Goldacre, Miguel A Hernán, Jonathan AC Sterne  full text  

Trends and clinical characteristics of COVID-19 vaccine recipients: a federated analysis of 57.9 million patients’ primary care records in situ using OpenSAFELY

Helen J Curtis, Peter Inglesby, Caroline E Morton, Brian MacKenna, Amelia Green, William Hulme, Alex J Walker, Jessica Morley, Amir Mehrkar, Seb Bacon, George Hickman, Chris Bates, Richard Croker, David Evans, Tom Ward, Jonathan Cockburn, Simon Davy, Krishnan Bhaskaran, Anna Schultze, Christopher T Rentsch, Elizabeth J Williamson, Anna Rowan, Louis Fisher, Helen I McDonald, Laurie Tomlinson, Rohini Mathur, Henry Drysdale, Rosalind M Eggo, Kevin Wing, Angel YS Wong, Harriet Forbes, John Parry, Frank Hester, Sam Harper, Shaun O’Hanlon, Alex Eavis, Richard Jarvis, Dima Avramov, Paul Griffiths, Aaron Fowles, Nasreen Parkes, Ian J Douglas, Stephen JW Evans, Liam Smeeth and Ben Goldacre (The OpenSAFELY Collaborative) Full Text

Predictors of COVID-19 vaccine hesitancy in the UK household longitudinal study

Elaine Robertson, Kelly S. Reeve, Claire L. Niedzwiedz, Jamie Moore, Margaret Blake, Michael Green, Srinivasa Vittal Katikireddi, Michaela J. Benzeval Full Text

BNT162b2 and ChAdOx1 nCoV-19 Vaccinations, Incidence of SARS-CoV-2 Infections and COVID-19 Hospitalisations in Scotland in the Delta era

Syed Ahmar Shah , Chris Robertson, Igor Rudan, Josephine LK Murray, Colin McCowan, Zoe Grange, Audrey Buelo, Christopher Sullivan, Colin R Simpson, Lewis D Ritchie, Aziz Sheikh full text

Other

Other

Pre-COVID-19 pandemic health-related behaviours in children (2018–2020) and association with being tested for SARS-CoV-2 and testing positive for SARS-CoV-2 (2020–2021): a retrospective cohort study using survey data linked with routine health data in Wales, UK 

Emily Marchant, Emily Lowthian ,Tom Crick, Lucy J Griffiths, Richard Fry, Kevin Dadaczynski,  Orkan Okan,  Michaela James,  Laura Cowley, Fatemeh Torabi, Jonathan Kennedy,  Ashley Akbari,  Ronan Lyons, Sinead Brophy  Ful Text

Association between household composition and severe COVID-19 outcomes in older people by ethnicity: an observational cohort study using the OpenSAFELY platform

Kevin Wing, Daniel J Grint, Rohini Mathur, Hamish P Gibbs, George Hickman, Emily Nightingale, Anna Schultze, Harriet Forbes, Vahé Nafilyan, Krishnan Bhaskaran, Elizabeth Williamson, Thomas House, Lorenzo Pellis, Emily Herrett, Nileesa Gautam , Helen J Curtis, Christopher T Rentsch , Angel YS Wong , Brian MacKenna, Amir Mehrkar, Seb Bacon, Ian J Douglas, Stephen JW Evans, Laurie Tomlinson, Ben Goldacre, Rosalind M Eggo on behalf of the OpenSAFELY consortium Full Text

Rates of serious clinical outcomes in survivors of hospitalisation with COVID-19: a descriptive cohort study within the OpenSAFELY platform The OpenSAFELY Collaborative;

John Tazare, Alex J Walker, Laurie Tomlinson, George Hickman, Christopher T Rentsch, Elizabeth J Williamson , Krishnan Bhaskaran, David Evans, Kevin Wing, Rohini Mathur, Angel YS Wong, Anna Schultze, Seb Bacon, Chris Bates, Caroline E Morton, Helen J Curtis, Emily Nightingale, Helen I McDonald, Amir Mehrkar, Peter Inglesby , Simon Davy, Brian MacKenna, Jonathan Cockburn, William J Hulme, Charlotte Warren-Gash, Ketaki Bhate, Dorothea Nitsch, Emma Powell, Amy Mulick, Harriet Forbes, Caroline Minassian, Richard Croker, John Parry, Frank Hester, Sam Harper , Rosalind M Eggo , Stephen JW Evans, Liam Smeeth, Ian J Douglas, Ben Goldacre  full text

OpenSAFELY: Representativeness of electronic health record platform OpenSAFELY-TPP data compared to the population of England

Colm Andrews, Anna Schultze, Helen Curtis, William Hulme, John Tazare, Stephen Evans, Amir Mehrkar, Sebastian Bacon, George Hickman, Christopher Bates, John Parry, Frank Hester, Sam Harper, Jonathan Cockburn, David Evans, Tom Ward, Simon Davy, Peter Inglesby, Ben Goldacre, Brian MacKenna, Laurie Tomlinson, Alex Walker full text

 

Severity of Severe Acute Respiratory System Coronavirus 2 (SARS-CoV-2) Alpha Variant (B.1.1.7) in England

Daniel J. Grint, Kevin Wing, Catherine Houlihan, Hamish P. Gibbs, Stephen J. W. Evans,  Elizabeth Williamson, Helen I. McDonald, Krishnan Bhaskaran, David Evans, Alex J. Walker, George Hickman, Emily Nightingale, Anna Schultze, Christopher T. Rentsch, Chris Bates, Jonathan Cockburn, Helen J. Curtis, Caroline E. Morton, Sebastian Bacon, Simon Davy,  Angel Y. S. Wong, Amir Mehrkar, Laurie Tomlinson, Ian J. Douglas,  Rohini Mathur, Brian MacKenna, Peter Ingelsby, Richard Croker, John Parry, Frank Hester, Sam Harper, Nicholas J. DeVito, Will Hulme, John Tazare, Liam Smeeth, Ben Goldacre and Rosalind M. Eggo Full Text

Ethnic differences in SARS-CoV-2 infection and COVID-19-related hospitalisation, intensive care unit admission, and death in 17 million adults in England: an observational cohort study using the OpenSAFELY platform

Rohini Mathur, Christopher T Rentsch, Caroline E Morton, William J Hulme, Anna Schultze, Brian MacKenna, Rosalind M Eggo, Krishnan Bhaskaran, Angel Y S Wong, Elizabeth J Williamson, Harriet Forbes, Kevin Wing, Helen I McDonald, Chris Bates, Seb Bacon, Alex J Walker, David Evans, Peter Inglesby, Amir Mehrkar, Helen J Curtis, Nicholas J DeVito, Richard Croker, Henry Drysdale, Jonathan Cockburn, John Parry, Frank Hester, Sam Harper, Ian J Douglas, Laurie Tomlinson, Stephen J W Evans, Richard Grieve, David Harrison, Kathy Rowan, Kamlesh Khunti, Nishi Chaturvedi, Liam Smeeth, Ben Goldacre, for the OpenSAFELY Full Text

Overall and cause-specific hospitalisation and death after COVID-19 hospitalisation in England: A cohort study using linked primary care, secondary care, and death registration data in the OpenSAFELY platform

Krishnan Bhaskaran, Christopher T. Rentsch, George Hickman, William J. Hulme, Anna Schultze, Helen J. Curtis, Kevin Wing, Charlotte Warren-Gash, Laurie Tomlinson, Chris J. Bates, Rohini Mathur, Brian MacKenna, Viyaasan Mahalingasivam, Angel Wong, Alex J. Walker, Caroline E. Morton, Daniel Grint, Amir Mehrkar, Rosalind M. Eggo, Peter Inglesby, Ian J. Douglas, Helen I. McDonald, Jonathan Cockburn, Elizabeth J. Williamson, David Evans, John Parry, Frank Hester, Sam Harper, Stephen JW Evans, Sebastian Bacon, Liam Smeeth, Ben Goldacre Full Text

Evaluation of antithrombotic use and COVID-19 outcomes in a nationwide atrial fibrillation cohort

Alex Handy, Amitava Banerjee, Angela Wood, Caroline E Dale, Cathie Sudlow, Christopher Tomlinson, Daniel Bean, Johan H Thygesen, Mehrdad A Mizani, Michail Katsoulis, Reecha Sofat, Richard Dobson, Rohan Takhar, Sam Hollings, Spiros Denaxas, Venexia Walker, on behalf of the CVD-COVID-UK Consortium Full Text 

Covid lockdowns in the UK: Estimating their effects on transmission

Emily Prestige, Julian Stander and Yinghui Wei Full text

 

Treatment

Comparative effectiveness of nirmatrelvir/ritonavir versus sotrovimab and molnupiravir for preventing severe COVID-19 outcomes in non-hospitalised high-risk patients during Omicron waves: observational cohort study using the OpenSAFELY platform

Bang Zheng, John Tazare, Linda Nab, Amelia CA. Green, Helen J. Curtis, Viyaasan Mahalingasivam, Emily L. Herrett, Ruth E. Costello, Rosalind M. Eggo, Victoria Speed, Sebastian CJ. Bacon, Christopher Bates, John Parry, Jonathan Cockburn, Frank Hester, Sam Harper, Andrea L. Schaffer, William J. Hulme, Amir Mehrkar, Stephen JW. Evans, Brian MacKenna, Ben Goldacre, Ian J. Douglas, and Laurie A. Tomlinson on behalf of the OpenSAFELY Collaborative full text

Comparative effectiveness of sotrovimab and molnupiravir for preventing severe COVID-19 outcomes in patients on kidney replacement therapy: observational study using the OpenSAFELY-UKRR and SRR databases

Bang Zheng , Jacqueline Campbell, Edward J Carr, John Tazare, Linda Nab, Viyaasan Mahalingasivam, Amir Mehrkar, Shalini Santhakumaran, Retha Steenkamp, Fiona Loud, Susan Lyon, Miranda Scanlon, William J Hulme, Amelia CA Green, Helen J. Curtis, Louis Fisher, Edward Parker, Ben Goldacre, Ian Douglas, Stephen Evans, Brian MacKenna, Samira Bell, Laurie A. Tomlinson,  Dorothea Nitsch and the OpenSAFELY Collaborative and LH&W NCS (or CONVALESCENCE) Collaborative full text

Comparative effectiveness of sotrovimab and molnupiravir for prevention of severe COVID-19 outcomes in non-hospitalised patients: an observational cohort study using the OpenSAFELY platform

Bang Zheng , Amelia CA Green , John Tazare , Helen J Curtis , Louis Fisher , Linda Nab , Anna Schultze , Viyaasan Mahalingasivam , Edward PK Parker , William J Hulme , Sebastian CJ Bacon , Nicholas J DeVito , Christopher Bates , David Evans , Peter Inglesby , Henry Drysdale , Simon Davy , Jonathan Cockburn , Caroline E Morton , George Hickman , Tom Ward , Rebecca M Smith , John Parry , Frank Hester , Sam Harper , Amir Mehrkar , Rosalind M Eggo , Alex J Walker , Stephen JW Evans , Ian J Douglas , Brian MacKenna , Ben Goldacre , Laurie A Tomlinson Full Text

 

Convalescence Study

Long COVID

Long COVID and financial outcomes: Evidence from four longitudinal population surveys

Rebecca Rhead, Jacques Wels, Bettina Moltrecht, Richard J. Shaw, Richard J. Silverwood, Jingmin Zhu , Alun Hughes, Nishi Chaturvedi, Evangelia Demou, Srinivasa Vittal Katikireddi & George B. Ploubidis full text

Characterising patterns of COVID-19 and long COVID symptoms: Evidence from nine UK longitudinal studies

Ruth C. E. Bowyer, Charlotte Huggins,   Renin Toms,  Richard J. Shaw, Bo Hou, Ellen J. Thompson, Alex Kwong,, Dylan Williams,  Milla Kibble,  George B. Ploubidis, Nic Timpson, Jonathan A. C. Sterne, Nish Chaturvedi,   Claire J. Steves, Kate Tilling,   Richard J. Silverwood the CONVALESCENCE Study  full text

‘I am just a shadow of who I used to be’—Exploring existential loss of identity among people living with chronic conditions of Long COVID

Chao Fang, Sarah Akhtar Baz,  Laura Sheard, JD Carpentieri  full text  t

“I don’t know what to do or where to go”. Experiences of accessing healthcare support from the perspectives of people living with Long Covid and healthcare professionals: A qualitative study in Bradford, UK

Sarah Akhtar Baz,  Chao Fang,  JD Carpentieri, Laura Sheard full text

Association of COVID-19 with arterial and venous vascular diseases: a 2 population-wide cohort study of 48 million adults in England and Wales

Rochelle Knight, Venexia Walker, Samantha Ip, Jennifer A Cooper, Thomas Bolton, Spencer Keene, Rachel Denholm, Ashley Akbari, Hoda Abbasizanjani, Fatemeh Torabi, Efosa Omigie, Sam Hollings, Teri Louise North, Renin Toms, Emanuele Di Angelantonio, Spiros Denaxas, Johan H Thygesen, Christopher Tomlinson, Ben Bray, Craig J Smith, Mark Barber, George Davey Smith, Nishi Chaturvedi, Cathie Sudlow, William N Whiteley, Angela Wood, Jonathan A C Sterne for the CVD-COVID-UK/COVID-IMPACT consortium and the Longitudinal Health and Wellbeing COVID-19 National Core Study Full text

Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records

Ellen J. Thompson, Dylan M. Williams, Alex J. Walker, Ruth E. Mitchell, Claire L. Niedzwiedz, Tiffany C. Yang, Charlotte F. Huggins, Alex S. F. Kwong, Richard J. Silverwood, Giorgio Di Gessa, Ruth C.E. Bowyer, Kate Northstone, Bo Hou, Michael J. Green, Brian Dodgeon, Katie J. Doores, Emma L. Duncan, Frances Williams, OpenSAFELY Collaborative, Andrew Steptoe, David J. Porteous, Rosemary R. C. McEachan, Laurie Tomlinson, Ben Goldacre, Praveetha Patalay, George B. Ploubidis, Srinivasa Vittal Katikireddi, Kate Tilling, Christopher T. Rentsch, Nicholas J Timpson, Nishi Chaturvedi, Claire J. Steves  full text

Illness duration and symptom profile in symptomatic UK school-aged children tested for SARS-CoV-2

Erika Molteni*, Carole H Sudre*, Liane S Canas, Sunil S Bhopal, Robert C Hughes, Michela Antonelli, Benjamin Murray, Kerstin Kläser, Eric Kerfoot, Liyuan Chen, Jie Deng, Christina Hu, Somesh Selvachandran, Kenneth Read, Joan Capdevila Pujol, Alexander Hammers, Tim D Spector, Sebastien Ourselin, Claire J Steves, Marc Modat, Michael Absoud, Emma L Duncan Full Text

Clinical coding of long COVID in English primary care: a federated analysis of 58 million patient records in situ using OpenSAFELY

Alex J WalkerBrian MacKennaPeter InglesbyLaurie TomlinsonChristopher T RentschHelen J CurtisCaroline E MortonJessica MorleyAmir MehrkarSeb BaconGeorge HickmanChris BatesRichard CrokerDavid EvansTom WardJonathan CockburnSimon DavyKrishnan BhaskaranAnna SchultzeElizabeth J WilliamsonWilliam J HulmeHelen I McDonaldRohini MathurRosalind M EggoKevin WingAngel YS WongHarriet ForbesJohn TazareJohn ParryFrank HesterSam HarperShaun O’HanlonAlex EavisRichard JarvisDima AvramovPaul GriffithsAaron FowlesNasreen ParkesIan J DouglasStephen JW EvansLiam SmeethBen Goldacre and (The OpenSAFELY Collaborative) Full Text