COVID-19 Longitudinal Health and Wellbeing National Core Study


Methods to improve long COVID diagnosis and treatment


The methods to improve long COVID diagnosis and management research theme is a collaboration with the National Institute for Health and Care Excellence (NICE) NICE | The National Institute for Health and Care Excellence

On 18th December 2020, NICE published a guideline on managing the long-term effects of COVID-19 (guideline reference NG188) alongside new clinical case definitions. This guideline covers a pathway from identification to treatment, and in addition includes advice on organising services. The guideline is a ‘living guideline’, changing in response to new developments in evidence and the availability of additional data and information.


Providing rapid evidence through research programs such as Convalescence will enable NICE to update guidelines faster and provide more timely care recommendations.  NICE is also interested in factors which affect the implementation of guidance, and how to overcome barriers and effectively implement guidance.


Using primary care records within the OpenSAFELY platform, we will investigate compliance with the NICE guidance on diagnosis and management of the long-term effects of COVID-19. We will also explore whether this differs by demographic, health, socioeconomic and regional characteristics.