Deep phenotyping - Imaging and functional testing in clinic, remote assessment and wearables
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Imaging of the brain, lungs, heart, liver and kidneys using magnetic resonance imaging (MRI)
Functional testing in clinic
Lung function using spirometry
Resting heart rate variability and electrocardiogram (ECG), lying, seated, standing brachial and central blood pressure (BP)
Cardiopulmonary exercise testing, including assessment of peak VO2, 12 lead ECG, blood pressure, muscle perfusion using near infrared spectroscopy, echocardiographic cardiac output and pre/post-exercise lactate
Retinal Optical Coherence Tomography angiography
Strength and physical performance
Blood and urine samples for storage
Remote assessment and wearables
MassSci App for remote assessment of physical and mental health fortnightly or monthly, depending on the parameter measured.
Cognitron (https://www.cognitron.co.uk/) for cognitive function, completed weekly for a month, and subsequently repeated 6 monthly.
Garmin vivoactive 4 wrist worn device to capture habitual activity, heart rate variability, sleep patterns, oxygen saturation (SpO2) and respiratory rate. In addition, participants will perform a standardised 6-minute walk test and a chair sit-stand test fortnightly for the first 6 months, then quarterly. All remote assessments will continue for up to 18 months.