Dr Wendy Heywood
I am a GOSH BRC supported Senior Research Fellow in Translational Mass Spectrometry and a Honorary Clinical Biochemist at Great Ormond Street Hospital.
Using expertise in proteomics for biomarker discovery and understanding disease mechanisms my group develops novel assay panels for clinical applications such as clinical trials and development of novel therapies. With GOSH BRC support and active collaborations with clinical partners we develop and streamline translation of novel biomarkers.
I have an active research group in Lysosomal Storage Disorders looking at biomarkers for Neuronal Lipofuscinosis (Battens disease), Niemann Pick C disease and the Glycosphingolipidoses disorders (Fabry, Gaucher & Krabbe disease). I also have a specific interest in the toxic mechanisms of lyso-lipids.
Recently my group have been involved in Covid-19 research with developing biomarkers for long covid, understanding the aetiology of PIMS-TS, developing multiplex SARS-CoV2 antigen and antibody assays for variant specific responses and identifying and developing novel biomarkers for early T-cell activation in blood.
Current Projects & Funding
Novel Immunoassay For Clinical Biomarkers Using Genetic Microdevices Innovate UK
Biomarkers for long covid Royal Free Charity
Assays for SARS-CoV-2 cellular immune responses Innovate UK
The Role of Toxic Glycosphingolipids in Parkinson's Disease Associated Pathology: How Lysosome Dysfunction Leads to Mitochondrial Dysfunction Parkinsons UK
Biomarkers for CLN2 Disease Treatment Monitoring and Disease Severity BDSRA
Using proteomic approaches to investigate the role of plasma and urine biomarkers for disease stratification in childhood hypertrophic cardiomyopathy Action Medical Research