UCL Great Ormond Street Institute of Child Health


Great Ormond Street Institute of Child Health


Neurodegenerative diseases

Principal Investigator, Dr Christy Hung, Research Fellow


Christy Hung is a Race Against Dementia Fellow and Alzheimer's Research UK Senior Fellow at UCL and the Francis Crick Institute.


My research interests and expertise revolve around leveraging human induced pluripotent stem cells (iPSCs) as a pre-clinical model to investigate the crucial role of endolysosomal dysfunction in neurodegenerative diseases.

UCL Appointments

  • Research Fellow
    University College London, Developmental Biology & Cancer Dept

Academic Positions

  • Race Against Dementia Fellow
    University of London, London, 2019 - present
  • Alzheimer's Research UK Senior Fellow
    University College London, London, 2023 - present

Fields of Research

  • Neurosciences
  • Neurology and neuromuscular diseases
  • Protein trafficking
  • Biochemistry and cell biology
Recent Publications


Hung C, Patani R, 4R tau drives endolysosomal and autophagy dysfunction in frontotemporal dementia, Autophagy, doi: 10.1080/15548627.2023.2300917


Hung C, Patani RElevated 4R tau contributes to endolysosomal dysfunction and neurodegeneration in VCP-related frontotemporal dementia, Brain, doi: 10.1093/BRAIN/AWAD370


Hung C, Tuck E, Stubbs V, Van der Lee SJ, Aalfs C, Van Spaendonk R, Scheltens P, Hardy J, Holstege H, Livesey FJSORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network, Cell Reports, doi: 10.1016/J.CELREP.2021.109259

Hung C, Livesey FJ, Endolysosome and autophagy dysfunction in Alzheimer diseaseAutophagy, doi: 10.1080/15548627.2021.1963630

Hung C, Importance of retrograde axonal transport in mitochondrial health and distributionCell Death Discovery, doi: 10.1038/S41420-021-00502-3


Hung C, Livesey FJAltered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer's DiseaseCell Reports, doi: 10.1016/J.CELREP.2018.11.095


Hung C, Live-Cell Imaging Reveals Tau Isoforms Imbalance Disrupts Traffic of APP Vesicles in Human NeuronsJournal of Neuroscience, doi: 10.1523/JNEUROSCI.3688-16.2017


Hung C, Coleman MP, KIF1A mediates axonal transport of BACE1 and identification of independently moving cargoes in living SCG neuronsTraffic, doi: 10.1111/TRA.12428