UCL Great Ormond Street Institute of Child Health


Great Ormond Street Institute of Child Health


Childhood Brain Tumours and Epilepsy Research Group

Our aim is to understand the cellular mechanisms that underlie childhood brain diseases and improve diagnosis for children. We focus on brain tumours and epilepsy.

Recent publications

A case series of Diffuse Glioneuronal Tumours with Oligodendroglioma-like features and Nuclear Clusters (DGONC). Neuropathol Appl Neurobiol (2020)  

Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes Cancer Discovery (2020)

Methylationbased algorithms for diagnosis: experience from neurooncology Journal of Pathology (2020)

The impact of molecular profiling on CNS tumour diagnosis and treatment: A paediatric population-based study The Lancet Child and Adolescent Health (2020)

Genotype-phenotype correlations in focal malformations of cortical development: a pathway to integrated pathological diagnosis in epilepsy surgery Brain Pathology (2019)

Histological heterogeneity in a large clinical cohort of juvenile idiopathic inflammatory myopathy: analysis by myositis autoantibody and pathological features. Neuropathology and Applied Neurobiology (2019)

DNA methylation-based classification of central nervous system tumours Nature (2018) 

Molecular characteristics of long-term epilepsy-associated tumours (LEATs) and mechanisms for tumour-related epilepsy (TRE). Neuropathology and Applied Neurobiology (2018) 

Comprehensive molecular characterisation of epilepsy-associated glioneuronal tumours. Acta Neuropathologica (2018)

Histopathological Findings in Brain Tissue Obtained from Epilepsy Surgery. New England Journal of Medicine (2018)