UCL Great Ormond Street Institute of Child Health


Great Ormond Street Institute of Child Health


Childhood Leukemia

Principal Investigator, Professor Owen Williams



Chromosomal translocations are frequent in infant and childhood leukaemia. These translocations often result in the generation of unique fusion genes. We investigate the function of fusion genes and downstream mediators that are commonly associated with infant and childhood acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML), using molecular and cellular modelling approaches. The goal of this research is to develop novel therapeutic approaches for leukaemias that are difficult to treat with conventional chemotherapy.

UCL Appointments

  • Professor of Cancer Biology


  • Doctor of Philosophy
    University College London, 1991

  • Bachelor of Science (Honours)
    University College London, 1987

Fields of Research

  • Cardiovascular medicine and haematology
  • Immunology
  • Cardiovascular medicine and haematology
  • Paediatrics
Team Members

Clemence Virely 
Post Doctoral Fellow
UCL Profiles page: Clemence Virely

Noelia Che
Post Doctoral Fellow
UCL Profiles page: Noelia Che

Danesh Sundar
PhD student
UCL Profiles page: Danesh Sundar