UCL Great Ormond Street Institute of Child Health


Great Ormond Street Institute of Child Health

Prof Joseph Standing

Prof Joseph Standing

Professor of Pharmacometrics

Infection, Immunity & Inflammation Dept

UCL GOS Institute of Child Health

Joined UCL
1st May 2011

Research summary

The major research focus is in using pharmacokinetic/pharmacodynamic modelling to answer questions such as: Does drug X affect disease process Y?  If so, what dose should we recommend?  Often these questions are most challenging when patients are children, and since maturation is a continuous not dichotomous process, understanding appropriate scaling for size and age is important.   Mechanistic, biologically plausible models are fitted using non-linear mixed effects, sometimes using 'priors'. 

Current projects include: Modelling SARS-CoV-2 viral dynamics under antiviral therapy in Phase II trials; Pharmacokinetic/pharmacodynamic studies of antimicrobial and antiviral agents in children; In vitro antimicrobial pharmacodynamics using the hollow fibre infection model; Models for immune reconstitution following bone marrow transplantation in children and personalised pre-transplant conditioning; HIV viral load and CD4 counts in adults and children, and investigating the role of antiretroviral treatment on long-term viral suppression and immune reconstitution; Pharmacokinetic/pharmacodynamic modelling to support antimicrobial stewardship.

The London Pharmacometrics Interest Group holds weekly meetings to discuss this kind of research, more information can be found here: 


Teaching summary

MSc/MRes module leader of Pharmacometrics CHLD0085.