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UCL Great Ormond Street Institute of Child Health

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Prof Waseem Qasim

Professor of Cell and Gene Therapy

ICH Infect, Imm, Infla. & Physio Med

UCL GOS Institute of Child Health

Joined UCL
1st Sep 2003

Research summary

Development and application of genome editing and gene based therapies.
  • I have a special interest T lymphocytes and how they can be used for powerful new therapies. My research at ICH/Great Ormond Street Hospital is centred on diagnosing and treating immune disorders, haematopoietic stem cell transplantation (HSCT) and gene based therapies for leukaemia and other conditions.
  • Lab projects are developing and testing viral vectors and gene editing reagents including TALENs and CRISPR/Cas9. Some of these are in clinical phase testing.
  • We are characterising cellular immune recovery after transplantation and investigating umbilical cord blood T cells.
  • My laboratory has a pipeline of vector development including gamma retroviral, lentiviral and transposon based systems, from initial development through to production at GMP.  
  • Development of genome editing and base editing for therapy is underway.
  • The procedures have also been adapted for gene therapy for skin disorders. We have recently completed trials of gene corrected skin grafts for Nethertons syndrome and a trial for Epidermolysis Bullosa using engineered fibroblasts.

Teaching summary

1. UCL- MSc Clinical Cell & Gene Therapy, module organiser and lecturer (2011)  
2. UCL-Lecturer MSc Human Genetics, Disease to gene therapy, BIOL3013 (2005-2010)
3. UCL-Lecturer on MRes in Biomedicine course,Gene Therapy for Immunodeficiency (2003-2010)
4. UCL- Lecturer on MSc in Paediatrics course,Cell and gene therapy for cancer (2007-2009)

Education

University College London
PhD, Gene Therapy | 2003
Royal College of Paediatrics and Child Health
MRCPCH, Paediatrics and Child Health | 1997
Royal College of Physicians
MRCP, Paediatrics and Child Health | 1996
University of Newcastle upon Tyne
BMEDSCI, Immunology | 1993
Newcastle University
MBBS, Medicine | 1993

Biography

2003-2007 Leukaemia Research Fund clinician scientist/lecturer in Paediatric Immunology/ Bone marrow transplantation, Institute of Child Health & Great Ormond Street Hospital, London

2007-2012 LLR/ICH Senior Clinical Lecturer, Institute of Child Health & Great Ormond Street Hospital, London

2012- 2015 Reader in Cell & Gene Therapy, Institute of Child Health & Great Ormond Street Hospital, London

2015-  NIHR Professor of cell and gene therapy developing next generation T cell gene therapies.

Publications