UCL Great Ormond Street Institute of Child Health


Great Ormond Street Institute of Child Health


Clone of John Anderson Research Page

Prof John Anderson, Professor of Experimental Paediatric Oncology and Honorary Consultant Oncologist




Chromosomal translocations are frequent in infant and childhood leukaemia. These translocations often result in the generation of unique fusion genes. We investigate the function of fusion genes and downstream mediators that are commonly associated with infant and childhood acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML), using molecular and cellular modelling approaches. The goal of this research is to develop novel therapeutic approaches for leukaemias that are difficult to treat with conventional chemotherapy.


UCL Appointments

  • Professor of Cancer Biology


  • Doctor of Philosophy
    University College London1991

  • Bachelor of Science (Honours)
    University College London1987

  • Bachelor of Medicine/Bachelor of Surgery
    University of Newcastle upon Tyne, 1991
  • Bachelor of Arts - Biochemistry
    University of Oxford, 1986

Fields of Research

  • Oncology and carcinogenesis
  • Clinical sciences
  • Immunology
  • Paediatrics
  • GOSH
  • CRUK
  • Olivia Hodson Cancer Fund
  • European Science Foundation
  • Entertainment Industry Foundation
  • Little Princess Trust
  • Children with Cancer UK
  • Solving Kids Cancer UK
  • Action Medical Research
  • MRC
Recent Publications


Anderson J, Barisa M. (2023). Enhancing the effectiveness of γδ T cells by mRNA transfection of chimeric antigen receptors or bispecific T cell engagers. Molecular Therapy – Oncolytics, doi: 10.1016/J.OMTO.2023.08.003

Waterhouse DJ, Privitera L, Anderson J...(2023). Enhancing intraoperative tumor delineation with multispectral short-wave infrared fluorescence imaging and machine learning. Journal of Biomedical Optics, doi: 10.1117/1.JBO.28.9.094804

Privitera L, Waterhouse DJ, Preziosi A...(2023). Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma.Cancer Research, doi:10.1158/0008-5472.CAN-22-2918

Vydra J, Cosimo E, Lesný P…(2023). A Phase I Trial of Allogeneic γδ T Lymphocytes From Haploidentical Donors in Patients With Refractory or Relapsed Acute Myeloid Leukemia. Clinical Lymphoma, Myeloma & Leukemia, doi:10.1016/J.CLML.2023.02.003


Hont AB, Dumont B, Sutton KS...(2022). The tumor microenvironment and immune targeting therapy in pediatric renal tumors. Pediatric Blood & Cancer, doi:10.1002/PBC.30110

Halliwell E, Vitali A, Muller H...(2022). Targeting of low ALK antigen density neuroblastoma using AND logic-gate engineered CAR-T cells. Cytotherapy, doi:10.1016/J.JCYT.2022.10.007

Birley K, Leboreiro-Babe C, Rota EM...(2022). A novel anti-B7-H3 chimeric antigen receptor from a single-chain antibody library for immunotherapy of solid cancers. Molecular Therapy, doi: 10.1016/J.OMTO.2022.08.008

Berlak M, Tucker E, Dorel M...(2022). Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells.Molecular Cancer, doi:10.1186/S12943-022-01583-Z

Ferry GM, Agbuduwe C, Forrester M...(2022). A Simple and Robust Single-Step Method for CAR-Vδ1 γδT Cell Expansion and Transduction for Cancer Immunotherapy. Frontiers in Immunology, doi:10.3389/FIMMU.2022.863155


Coorens TH, Collord G, Lu W, Mitchell E, Ijaz J, Roberts T, Oliver TR, Burke A, Gattens M, Dickens E, ... Anderson J, ... Behjati, S. (2021). Clonal hematopoiesis and therapy-related myeloid neoplasms following neuroblastoma treatment.. Blood, doi:10.1182/blood.2020010150

Kildisiute, G., Kholosy, W.M., Young, M.D., Roberts, K., Elmentaite, R., van Hooff, S.R., Pacyna, CN., Khabirova, E., Piapi, A., ...Anderson, J.,  ...Behjati, S. (2021). Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell.. Sci Adv, 7 (6), doi:10.1126/sciadv.abd3311


Pearson, A.D.J., Rossig, C., Lesa, G., Diede, S.J., Weiner, S., Anderson, J., Gray J, Geoerger, B., Minard-Colin, V., ...Vassal, G. (2020). ACCELERATE and European Medicines Agency Paediatric Strategy Forum for medicinal product development of checkpoint inhibitors for use in combination therapy in paediatric patients.. Eur J Cancer, 127 52-66. doi:10.1016/j.ejca.2019.12.029

Straathof, K., Flutter, B., Wallace, R., Jain, N., Loka, T., Depani, S., Wright, G., Thomas, S., Cheung, GW-K., ...Anderson, J. (2020). Anti-tumor activity without on-target off-tumor toxicity of GD2-Chimeric Antigen Receptor T cells in patients with neuroblastoma. Science Translational Medicine, doi:10.1126/scitranslmed.abd6169

Gavriil, A., Barisa, M., Halliwell, E., Anderson, J. (2020). Engineering solutions for mitigation of chimeric antigen receptor T-cell dysfunction. Cancers, 12 (8), 1-24. doi:10.3390/cancers12082326

Paraboschi, I., De Coppi, P., Stoyanov, D., Anderson, J., Giuliani, S. (2020). Fluorescence imaging in pediatric surgery: State-of-the-art and future perspectives.. J Pediatr Surg, doi:10.1016/j.jpedsurg.2020.08.004

Coorens, THH., Farndon, SJ., Mitchell, TJ., Jain, N., Lee, S., Hubank, M., Sebire, N., Anderson, J., Behjati, S. (2020). Lineage-independent tumors in bilateral neuroblastoma. New England Journal of Medicine, 383 (19), 1860-1865. doi:10.1056/NEJMoa2000962

Zormpas-Petridis, K., Poon, E., Clarke, M., Jerome, N.P., Boult, J.K.R., Blackledge, M.D., Carceller, F., Koers, A., Barone, G., ...Anderson, J., ...Jamin, Y. (2020). Noninvasive MRI native T1 mapping detects response to MYCN-targeted therapies in the Th-MYCN model of neuroblastoma.. Cancer Research, doi:10.1158/0008-5472.CAN-20-0133

Grabovska, Y., Mackay, A., O'Hare, P., Crosier, S., Finetti, M., Schwalbe, E.C., Pickles, JC., Fairchild, AR., Avery, A., ...Anderson, J.,  ...Williamson, D. (2020). Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity.. Nat Commun, 11 (1), 4324. doi:10.1038/s41467-020-18070-y


George, S.L., Izquierdo, E., Campbell, J., Koutroumanidou, E., Proszek, P., Jamal, S., Hughes, D., Yuan, L., Marshall, LV., ...Anderson, J., ... Chesler L. (2019). A tailored molecular profiling programme for children with cancer to identify clinically actionable genetic alterations. European Journal of Cancer, doi:10.1016/j.ejca.2019.07.027

Coorens, T.H.H., Treger, T.D., Al-Saadi, R., Moore, L., Tran, M.G.B., Mitchell, T.J., Tugnait, S., Thevanesan, C., Young, MD., ...Anderson, J., ...Behjati S. (2019). Embryonal precursors of Wilms tumor.. Science, 366 (6470), 1247-1251. doi:10.1126/science.aax1323

Nieddu, V., Piredda, R., Bexell, D., Barton, J., Anderson, J., Sebire, N., Kolluri, K., Janes, SM., Karteris, E., Sala, A. (2019). Engineered human mesenchymal stem cells for neuroblastoma therapeutics. Oncology Reports, doi:10.3892/or.2019.7152

Fisher, J., Sharma, R., Don, D.W., Barisa, M., Hurtado, M.O., Abramowski, P., Porter, L., Day, W., Borea, R., Inglott, S., Anderson, J., Pe'er, D. (2019). Engineering γδT cells limits tonic signaling associated with chimeric antigen receptors.. Sci Signal, 12 (598), doi:10.1126/scisignal.aax1872

Barton, J., Pacey, K., Jain, N., Kasia, T., Edwards, D., Thevanesan, C.,Straathof, K., Barone, G., Anderson, J. (2019). Establishment and phenotyping of neurosphere cultures from primary neuroblastoma samples.. F1000Res, 8 823. doi:10.12688/f1000research.18209.1

Mahamdallie, S., Yost, S., Poyastro-Pearson, E., Holt, E., Zachariou, A., Seal, S., Elliott, A., Clarke, M., Warren-Perry, M., ...Anderson, J.,  ...Rahman, N. (2019). Identification of new Wilms tumour predisposition genes: an exome sequencing study.. Lancet Child Adolesc Health, doi:10.1016/S2352-4642(19)30018-5

Jain, N., Halbert, J., Patel, P.A., Biassoni, L., Anderson, J., Sebire, N., McHugh, K., Barone, G. (2019). Importance of Magnetic Resonance Imaging With Diffusion-weighted Imaging in Guiding Biopsy of Nodular Ganglioneuroblastoma: A Case Report.. J Pediatr Hematol Oncol, doi:10.1097/MPH.0000000000001686

Yogev, O., Almeida, G.S., Barker, K.T., George, S.L., Kwok, C., Campbell, J., Zarowiecki, M., Kleftogiannis, D., Smith, LM., ...Anderson, J., ...Chesler, L. (2019). In vivo modelling of chemo-resistant neuroblastoma provides new insights into chemo-refractory disease and metastasis. Cancer Research, doi:10.1158/0008-5472.CAN-18-2759

Zormpas-Petridis, K., Jerome, N.P., Blackledge, M.D., Carceller, F., Poon, E., Clarke, M., McErlean, CM., Barone, G., Koers, A., ...Anderson, J.,  ...Jamin, Y. (2019). MRI Imaging of the Hemodynamic Vasculature of Neuroblastoma Predicts Response to Antiangiogenic Treatment. Cancer Research, doi:10.1158/0008-5472.CAN-18-3412

Youssef, G., Gillett, C., Rampling, D., Chagtai, T., Virasami, A., Barton, J., Edwards, D., Sebire, N., Anderson, J., Montano, X. (2019). The presence of Y674/Y675 phosphorylated NTRK1 via TP53 repression of PTPN6 expression as a potential prognostic marker in neuroblastoma.. Hum Pathol, doi:10.1016/j.humpath.2018.12.003

Ollé Hurtado, M., Wolbert, J., Fisher, J., Flutter, B., Stafford, S., Barton, J., Jain, N., Barone, G., Majani, Y., Anderson, J. (2019). Tumor infiltrating lymphocytes expanded from pediatric neuroblastoma display heterogeneity of phenotype and function.. PLoS One, 14 (8), e0216373. doi:10.1371/journal.pone.0216373


Birley, K., Chester, K., Anderson, J. (2018). Antibody based therapy for childhood solid cancers. Current Opinion in Chemical Engineering, 19 153-162. doi:10.1016/j.coche.2018.01.005

Fisher, J., Anderson, J. (2018). Engineering Approaches in Human Gamma Delta T Cells for Cancer Immunotherapy. FRONTIERS IN IMMUNOLOGY, 9 doi:10.3389/fimmu.2018.01409

Wegert, J., Vokuhl, C., Collord, G., Velasco-Herrera, MDC., Farndon, SJ., Guzzo, C., Jorgensen, M., Anderson, J., Slater, O., ...Behjati, S. (2018). Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants. NATURE COMMUNICATIONS, 9 doi:10.1038/s41467-018-04650-6

Group members

Dr Marta Barisa
Senior Research Associate 
UCL Profiles page: Marta Barisa

Ms Courtney Himsworth
Research Assistant
UCL Profiles page: Courtney Himsworth

Miss Farah Alam
PhD student
UCL Profiles page: Farah Alam

Miss Gabrielle Ferry
Research Fellow
UCL Profiles page: Gabrielle Ferry

Ms Henrike Muller
PhD student
UCL Profiles page: Henrike Muller

Ms Marilena Nicolaidou
Research Technician

Miss Meshael Artuki
PhD student

UCL Profiles page: Meshael Artuki

Dr Sonia Morlando
Research Fellow

Ms Sophie Munnings-Tomes
Research Assistant


Previous Lab Members:

Kathleen Birley
Emma Halliwell
Beth Hawkins
Kristen Koopmans
Neha Jane
Artemis Gavriil
Irene Paraboschi
Laura Privitera
Charles  Agbuduwe
Carla Bautista
Jennifer Frosch
Nisansala Wisidagamage Don
Alice Vitali
Ilia Leontari
Clara Leboreiro Babe