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August 2018
Together with our many co-applicants, we have been awarded funding
from the School of Life and Medical Sciences and the UCH Biomedical
Research Centre for a 10X Genomics Chromium for single cell RNA-seq
and ATAC-seq.
August 2018
We have been awarded funding from Bloodwise to determine the role of
enhancer RNAs in leukaemia. We're looking forward to working on this
project together with Marc Mansour and in collaboration with Dan Bose.
May 2018
Garima Khandelwal has joined the lab as bioinformatics research associate.
July 2018
Richard has been promoted to Professor! Thanks very much to the lab
for all their hard work.
July 2018
Maria has passed her MPhil to PhD transfer viva! Thanks for Graham
Lord and Lucy Walker for examining her!
News archive
- 2017
July 2017
We have been awarded a project grant from the MRC for our work on the
recruitment of Mediator and the Super Elongation Complex by T-bet and
its disruption in inflammatory disease.April 2017
Manuel has passed his MPhil to PhD transfer viva! Thanks to Paola
Scaffidi and Sue Hadjur for examining him!February 2017
Although non-coding RNAs have roles in transcription and chromatin function, nascent pre-mRNA is usually considered to be passive during these processes. Our Perspectives article setting out the evidence that both nascent coding and non-coding RNA regulates transcription and chromatin function has been published in Nature Reviews Molecular Cell Biology.
January 2017
Genetic variants associated with Inflammatory bowel disease and celiac disease alter binding of the Th1 lineage-specifying factor T-bet and gene expression. Published in PLOS Genetics
- 2016
June 2016
Our study revealing that T-bet functions to activate Th1 genes through Mediator and the Super Elongation Complex has been published in Cell Reports.
May 2016
The interaction of PRC2 with RNA or chromatin is mutually antagonistic: Our study identifying the RNAs directly bound by PRC2 in living cells, revealing that RNA antagonises PRC2 recruitment to chromatin, has been published online at Genome Research.
- 2015
October 2015
Welcome! Manuel de Jesus Tavares Cornejo, who has joined the lab with CONACyT and UCL Overseas Research Scholarships.
March 2015
Our collaborative study with Alison Sinclair identifying the human genes directly targeted by the EBV transcription factor Zta has been published in NAR. Catherine has passed her PhD viva - congratulations!February 2015
Our collaborative study with Steen Ooi on the role of the Dnmt3L ADD domain in spermatogenesis is published in Cell Reports.
- 2014
December 2014
Our collaborative study with Eugene Butcher and Aida Habtezion on the differences in lineage-specific expression of GPR15 between human and mice is published in Nature Immunology. Carla has passed her MPhil viva - congratulations!January 2014
We are seeking to hire a talented scientist to lead our computational analysis of iClip, RNA-Seq and ChIP-Seq data, and to generate new hypotheses about how transcription and chromatin structure are regulated. (Applications closed)
April 2014
Arnulf Hertweck has joined the lab from our close collaborator Graham Lord’s group. Arnulf is working on the regulation of transcription elongation in T cells and the interplay between T-bet and GATA3.
March 2014
Lenka Skalska has joined the lab as a post-doc to work on the interaction between chromatin regulators and RNA. Lenka completed her first postdoc with Sarah Bray and before that, her PhD with Martin Allday.
February 2014
Alessandro Riccombeni has left the lab to take up a senior bioinformatician role at GeneStack. All the best Alessandro!.
July 2014
Chris Yates has joined the lab as postdoctoral bioinformatics associate. Chris recently completed his PhD with Michael Sternberg at Imperial, where he developed SuSPect, a method for predicting the effects of missions mutations. Our paper revealing that HIV Tat, in addition to binding to HIV TAR RNA, also associates with a specific set of cellular RNAs, has been published in Retrovirology.
- 2013
December 2013
Refik's paper showing how T-bet controls Th17 lineage differentiation by directly suppressing IRF4 is out now in J Immunol.
November 2013
We've been awarded a grant by the BBSRC to support our research into how T-bet redistributes GATA3 binding across the genome and to determine its role in T-cell differentiation and plasticity.
November 2013
Filipa Reis has just joined the lab as a post-doc to work on the interaction between PRC2 and RNA. Filipa recently completed her PhD working on the exosome with Cecília Maria Arraiano at ITQB in Portugal.
September 2013
Our collaborative paper with Michelle West's lab identifying how EBV transcription factors reprogram the host cell is published in PLoS Pathogens.
September 2013
The Regulatory Genomics lab officially joins the UCL Cancer Institute.
