Clinical Trials

The EURO Ewing Consortium supports clinical trials for Ewing sarcoma.

rEECur

rEECur - International Randomised Controlled Trial of Chemotherapy for the Treatment of Recurrent and Primary Refractory Ewing Sarcoma

Publications

ASCO (2019) Results of the first interim assessment of rEECur, an international randomized controlled trial of chemotherapy for the treatment of recurrent and primary refractory Ewing sarcoma - abstract

ASCO (2020) Results of the second interim assessment of rEECur, an international randomized controlled trial of chemotherapy for the treatment of recurrent and primary refractory Ewing sarcoma (RR-ES) - abstract

ASCO (2020) Correlation of response with progression-free (PFS) and overall (OS) survival in relapsed/refractory Ewing sarcoma (RR-ES): Results from the rEECur trial. - abstract

ASCO (2022) Phase III assessment of topotecan and cyclophosphamide and high-dose ifosfamide in rEECur: An international randomized controlled trial of chemotherapy for the treatment of recurrent and primary refractory Ewing sarcoma (RR-ES) - abstract

Euro Ewing 2012

Euro Ewing 2012 - International Randomised Controlled Trial for the Treatment of Newly Diagnosed Ewing's Sarcoma Family of Tumours

This trial is now closed to recruitment.

Trial results

The trial found that the USA treatment (VDC-IE) received by patients was more effective and less toxic, for all stages of newly diagnosed ES, than the European standard treatment (VIDE).

October 2022 - Euro Ewing 2012 clinical trial results are published in the Lancet Journal
The results of the practice-changing clinical trial for patients with newly-diagnosed Ewing sarcoma have been published in the Lancet journal. Free access to the full article will be available for a limited time, and for patients and the public, a plain English summary, reviewed and edited by the EEC patient advocates can be viewed here as well as a version in Italian, translated by one of the EEC patient advocates. The EEC would like to thank all the patients and researchers for their contribution to this important trial.

Publications

Comparison of two chemotherapy regimens in patients with newly diagnosed Ewing sarcoma (EE2012): an open-label, randomised, phase 3 trial - paper and plain English summary

ASCO (2020) Comparison of two chemotherapy regimens in Ewing sarcoma (ES): Overall and subgroup results of the Euro Ewing 2012 randomized trial (EE2012) - abstract

Trials (2020) International randomised controlled trial for the treatment of newly diagnosed EWING sarcoma family of tumours – EURO EWING 2012 Protocol - protocol paper

Results for Euro Ewing 2012 and rEECur were posted in accordance with deliverables D1.6 and D2.6 in September 2018.

Bone Cancer Research Trust also provides information on clinical trials open to ES patients in the UK.

Clinical trials in development

INTER-EWING-1 - CI Bernadette Brennan, University of Manchester, UK

iEuroEwing - CI Uta Dirksen, University Hospital Essen, Germany