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CRUK UCL Centre Events

Find out more about CRUK UCL Centre events, including our multidisciplinary seminar series, events from our partners, and how you can get involved.


For CRUK City of London Centre events see www.colcc.ac.uk/events


 

CRUK UCL Centre & UCL Cancer Domain Multidisciplinary Seminar Series

Microvasculature Mechanics: From in vitro Microfluidic Models to Computational Simulations

Dr Emad Moeendarbary, Dept of Mechanical Engineering & Dr Fabian Spill, School of Mathematics, Uni of Birmingham

Date: Thursday 12th September
Time: 12:00-13:00
Location: Paul O'Gorman Building Café, UCL Cancer Institute, 72 Huntley Street, London, WC1E 6BT

With advances in microfluidic technologies and computational modelling we now have the capability to create models of vasculature for studies of function in health and disease. These models have numerous applications ranging from the fundamental study of multi-cellular interactions to screening for new agents to treat disease. In the first talk we focus on the dynamics of endothelial cells in a two-dimensional monolayer. Here, endothelial cells constantly push and pull on neighbouring cells, leading to forces on VE-cadherin mediated cell-cell junctions. These junctions are highly dynamic, and their rupture may lead to the autonomous formation of gaps in the endothelium.

We present a novel mathematical model that predicts the frequency, lifetime and size of these gaps, and validate the predictions with experiments of HUVEC monolayers. We find that gaps occur more often at the vertices of three or more cells, as opposed to the borders between two cells. Interestingly, cancer cells follow this trend and primarily extravasate at the vertices. Notably, they do so even when they first arrest on the two cell border, where they subsequently typically migrate towards the endothelial vertices. This indicates that the cancer cells exploit the autonomously forming gaps, and do not necessarily rely on signalling to the endothelium to initiate gap formation.

In the second talk, we focus on vasculogenesis and present our latest results that unravel the role of intrinsic mechanical factors in the morphogenesis of microvascular networks. While the effects of extrinsic mechanical factors on angiogenesis and vasculogenesis have been investigated extensively, less is known about the role of intrinsic mechanical cues that emerge through dynamic cell-cell and cell-ECM interactions. We present our novel fluidic platforms enabling us to study the mechanics of self-assembling, 3D, perfusable vascular networks. We found that supporting fibroblasts must physically interact with endothelial cells and the surrounding matrix to generate large-scale functional microvasculature that remains stable for several weeks. Interestingly, the enhanced stability and functionality is accompanied by a drastic increase in vascular tissue stiffness.


 

2nd Crick International Cancer Conference

Date: 15th-17th September 2019
Location: Francis Crick Institute, 1 Midland Road, NW1 1ST, London

This is a great opportunity for students and post-doc to present their work alongside a world class line of speakers. Abstracts are actively encouraged and there will be a prize for the best selected talk and best poster. It will also be a great opportunity to network with other CRUK City of London Centre researchers and those from further afield.

To be considered for a short talk or poster presentation please submit an abstract of no more than 250 words to events@crick.ac.uk by Friday 9th August 2019. Please note abstract submissions can only be accepted from registered attendees.

Registration closes 31 August.

Register Here

 


 

Early Detection of Cancer Conference

Date: 24th-26th September 2019
Location: Stanford University, Stanford, CA

Canary Center at Stanford, Cancer Research UK and OHSU Knight Cancer Institute are bringing the Early Detection of Cancer Conference to Stanford University, California.
Join a stellar line-up of contributors including Victor Velculescu, Jelle Wesseling, Ruth Etzioni, Gerrit Meier, Tony Ng, Fiona Walter, James Brooks, George Hanna and many more. Abstracts are currently being accepted, submit yours here.

Register Here

 

 


 

Cancer Research UK Innovation Summit 2019

Date: 7th October 2019
Location: Alderley Park, Alderley Edge, Macclesfield, SK10 4TG

CRUK’s second Innovation Summit will showcase the motives for, and benefits of, translating your research through entrepreneurial activities and the infrastructure available to support you. The programme will include topics covering the incentives for engaging in entrepreneurship and how to overcome the challenges that an entrepreneur may face. This is an excellent opportunity to network with members of the local entrepreneurial ecosystem, with a marketplace exhibit and 1-on-1 advice clinics allowing you to engage personally with CRUK, our partners and local industry.

This year’s conference explores:

  • Why engage and lessons learned - A panel session with post-doc entrepreneurs on their motivations, successes, and knowledge gained.
  • What route should I take? - An interactive session comparing established routes to commercialisation, ranging from licensing to spin-out.
  • What support is available for me? - An opportunity to gain insight from key members of the local entrepreneurial ecosystem on the infrastructure available in the region to enable commercialisation. 

Please note that spaces at the conference are limited, so reserve your free space here:

Register Here

 

 


 

Cancer Research UK–AACR Joint Conference on Engineering and Physical Sciences in Oncology

Date: 15th-17th October 2019
Location: Leonardo Royal Hotel London, Tower Bridge

The exciting three-day programme features leading international scientists including Sangeeta Bhatia (MIT), Oliver Jonas (Harvard Medical School), Molly Stevens (Imperial College London) and Bern Pichler (University Hospital Tübingen).

Sessions include:

  • Detect: Monitoring disease state - Chair and speaker: Kevin Brindle, CRUK Cambridge Institute, UK
    Focussing on new technologies to monitor all aspects of disease state, from therapy response to resistance detection in both clinical and preclinical settings
  • Understand: Cancer research in the big data era - Chair and speaker: Dana Pe'er, Sloan Kettering Institute, US
    Highlighting how big data and artificial intelligence can accelerate cancer research
  • Treat: Novel therapeutic approaches - Chair and speaker: Angela Koehler, Massachusetts Institute of Technology, US
    Discussing emerging therapeutics and therapeutic technologies that can help in the fight against cancer

Delegate places are filling up fast for the Cancer Research UK–AACR Joint Conference on Engineering and Physical Sciences in Oncology in London this October. To avoid disappointment, book your spot by Tuesday 17 September.

Register Here

 

 


 

2019 NCRI Cancer Conference

Date: 3rd-5th November 2019
Location: Scottish Event Campus, Glasgow, UK

The programme is designed for cancer researchers working across the research spectrum including areas such as:

  • Cancer discovery / underpinning research
  • Prevention
  • Early detection, diagnosis and prognosis
  • Treatment
  • Living with and beyond cancer

Register Here

 

 


 

Molecular Analysis for Personalised Therapy Congress

Date: 7th-9th November 2019
Location: London

Early bird tickets available now until 5th September.

Join experts in precision medicine in oncology to discuss ways to integrate insights from tumour sample analysis into daily practice. The three-day programme will explore insights into the latest technologies, such as AI and radiomics, modern approaches in tumour immunology, single cell analysis and targeting the PI3K pathway.

The impressive line-up of speakers includes Sergio Quezada, Andrew Biankin, Clare Turnbull, Trevor Graham, Jolanda de Vries and many more.

Register Here

 

 


 

UCL Cancer Domain Symposium 2019 - Recordings now available

The UCL Cancer Domain Symposium, entitled 'Rethinking Cancer', took place on Monday 13 June 2019.

Over 430 people attended the inaugural UCL Cancer Domain Symposium. Speakers and attendees representing a wide range of disciplines across UCL and partner organisations, assembled for the first time at a large scale to consider challenges and opportunities in cancer research, prevention and treatment, from biological, clinical, technical, economic and societal perspectives.

Video recordings of the presentations and panel discussions can now be found here. They are a great resource, so if you missed the event, or even if you were there, please take a look for a unique insight into some of the most pressing questions and cutting edge research being deployed to beat cancer research and the innovative multi-disciplinary approaches that are being deployed across UCL and beyond. 

A full programme from the day can be found here.


 

Multidisciplinary Seminar Series

The CRUK UCL Centre will be reinstating the popular multidisciplinary seminar series later this year in partnership with the UCL Cancer Domain. The series highlights research from a wide range of disciplines throughout UCL and other institutions across London with an aim to forge multi-disciplinary collaborations to the benefit of our cancer research programmes. These seminars have been pivotal to our success in gaining numerous multidisciplinary awards, as evidenced by UCL attaining six of these awards since their inception by CRUK.

 

Next Seminar: Microvasculature Mechanics: From in vitro Microfluidic Models to Computational Simulations

Dr Emad Moeendarbary, Dept of Mechanical Engineering & Dr Fabian Spill, School of Mathematics, Uni of Birmingham

Date: Thursday 12th September
Time: 12:00-13:00
Location: Paul O'Gorman Building Café, UCL Cancer Institute, 72 Huntley Street, London, WC1E 6BT

With advances in microfluidic technologies and computational modelling we now have the capability to create models of vasculature for studies of function in health and disease. These models have numerous applications ranging from the fundamental study of multi-cellular interactions to screening for new agents to treat disease. In the first talk we focus on the dynamics of endothelial cells in a two-dimensional monolayer. Here, endothelial cells constantly push and pull on neighbouring cells, leading to forces on VE-cadherin mediated cell-cell junctions. These junctions are highly dynamic, and their rupture may lead to the autonomous formation of gaps in the endothelium.

We present a novel mathematical model that predicts the frequency, lifetime and size of these gaps, and validate the predictions with experiments of HUVEC monolayers. We find that gaps occur more often at the vertices of three or more cells, as opposed to the borders between two cells. Interestingly, cancer cells follow this trend and primarily extravasate at the vertices. Notably, they do so even when they first arrest on the two cell border, where they subsequently typically migrate towards the endothelial vertices. This indicates that the cancer cells exploit the autonomously forming gaps, and do not necessarily rely on signalling to the endothelium to initiate gap formation.

In the second talk, we focus on vasculogenesis and present our latest results that unravel the role of intrinsic mechanical factors in the morphogenesis of microvascular networks. While the effects of extrinsic mechanical factors on angiogenesis and vasculogenesis have been investigated extensively, less is known about the role of intrinsic mechanical cues that emerge through dynamic cell-cell and cell-ECM interactions. We present our novel fluidic platforms enabling us to study the mechanics of self-assembling, 3D, perfusable vascular networks. We found that supporting fibroblasts must physically interact with endothelial cells and the surrounding matrix to generate large-scale functional microvasculature that remains stable for several weeks. Interestingly, the enhanced stability and functionality is accompanied by a drastic increase in vascular tissue stiffness.

Upcoming Seminars

Professor Alethea Tabor & Dr Vijay Chudasama - Department of Chemistry

Date: Thursday 17th October 2019
Time: 12:00-13:00
Location: Paul O'Gorman Building Café, UCL Cancer Institute, 72 Huntley Street, London, WC1E 6BT


Examples of our most recent seminars are listed below.

SpeakerTopicDepartment
Professor Guillaume Charras
Dr Guillaume Salbreux
Control of cell and tissue shape by the cytoskeleton: linking molecular mechanisms to mechanicsLondon Centre for Nanotechnology
Professor Chris Clark
Dr Patrick Hales
Advanced Magnetic Resonance Imaging in Paediatric Neuro-OncologyICH Developmental Neurosciences Programme

Dr Kate Ricketts
Professor Quentin Pankhurst

Inorganic nanoparticles: a theranostic agent for cancerResearch Department of Targeted Intervention (London Centre of Nanotechnology)
Dept of Med Phys & Biomedical Eng
Professor Paul Dalby
Dr Qasim Rafiq
Future Targeted Healthcare Manufacturing HubDepartment of Biochemical Engineering
Dr Paul Barber
Professor Tony Ng
Fluorescence Lifetime Imaging Microscopy in Cancer ResearchResearch Department of Oncology

Professor Paul Beard

Photoacoustic imaging as a tool for cancer research

Department of Medical Physics and Bioengineering
Dr Alessandro OlivioX-ray Phase Contrast Imaging (XPCI) and its potential applications in cancer researchDepartment of Medical Physics and Bioengineering
Dr Matt ClarksonDevelopment of a system for image guided laparoscopic liver resectionDepartment of Medical Physics and Bioengineering
Professor Gary RoyleResearch opportunites in proton therapyDepartment of Medical Physics and Bioengineering
Dr Dan Stoyanov- Inferring geometry from endoscopic video during minimally invasive cancer surgeryDepartment of Computer Science, Centre for Medical Image Computing
Professor Ralph Sinkus- Imaging Tissue BiomechanicsDepartment of Biomedical Engineering, KCL
Professor Tony Ng- Tracking tumour evolution by imaging tissue/ exosome-based oncogenic rewiringDepartment of Cancer Cell Biology and Imaging, Comprehensive Cancer Imaging Centre, KCL
Professor Heather Payne- RADAR: Radiotherapy Advances and Research for prostate cancerDepartment of Clinical Oncology
Professor Guillaume Charras- Reverse Engineering Cellular InteractionsLondon Centre for Nanotechnology
Professor David KlugSingle Cell Protein Analysis applied to Clinical ProblemsDepartment of Chemistry, Imperial College London