UCL Cancer Institute


Feldberg Prize Lecture, Professor Volker Haucke

02 September 2022, 4:00 pm–7:00 pm

Professor Volker Haucke

Hosted by Frances Brodsky & Bart Vanhaesebroeck, Professor Volker Haucke will give his Feldberg Prize Lecture in Chadwick Building B05 LT. Following the lecture, a drinks reception will be hosted in the UCL Cancer Institute.

Event Information

Open to





Georgie Perry – Cancer Institute
0203 108 2212


Chadwick Building B05 LT
Gower Street
United Kingdom

"Lipid switches in cell physiology: From nutrient signals to disease."

Phosphoinositides (PIs) form a minor class of phospholipids with crucial functions in cell physiology, ranging from cell signalling and motility to a role as signposts of compartmental membrane identity and dynamics. In fed cells, phosphatidylinositol 3-phosphates are present at the plasma membrane and within the endolysosomal system, where they serve as key regulators of both cell signalling and of intracellular membrane dynamics, while PI 4-phosphates delineate the secretory pathway.

In his talk Prof Volker Haucke will discuss the localization, regulation, and molecular mechanism of action of PI 3-kinases and their roles in endocytosis and in nutrient signaling within the endolysosomal system. Moreover, he will cover their recent advances in the analysis of the metabolic pathways that regulate the cellular synthesis and turnover of distinct PI phosphates at endosomes or lysosomes in response to altering nutrient conditions, discuss the mechanisms by which these lipids regulate endolysosomal membrane dynamics and metabolism, and provide examples of how dysregulation of these pathways may cause human disease. Our data provide a framework for how PI phosphate metabolism is integrated into the cellular network and identify PI kinases as targets for future therapeutics.

About the Speaker

Professor Volker Haucke

Professor of Molecular Pharmacology at Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany

Volker Haucke is Director at the Leibniz Forschungsinstitut für Molekulare Pharmacologie (FMP) and professor of molecular pharmacology at the Freie Universität Berlin and a member of the NeuroCure Cluster of Excellence. The overarching goal of his studies is to mechanistically understand how signaling lipids control endocytic and endolysosomal membrane dynamics and, thereby cell physiology and pathophysiology. Volker Haucke is a distinguished scientist whose contributions have been recognized by his election as a Member of Leopoldina, the German National Academy of Science (Halle), a Member of the Berlin-Brandenburg Academy of Science, the Avanti Award of the American Society for Biochemistry and Molecular Biology (ASBMB) 2017, and the Feldberg Prize for Research in Physiology and Pharmacology 2020. Since 2014 he is an elected member of the European Molecular Biology Organisation (EMBO).

More about Professor Volker Haucke