Online: Clinical Seminar Series - Marc Mansour
03 December 2020, 10:00 am–11:00 am
Dr Marc Mansour (UCL / UCLH) presents: Current and emerging therapeutic approaches for T-cell acute lymphoblastic leukaemia.
Event Information
Open to
- All
Organiser
-
Veronica Dominguez
Hosted by: Prof Daniel Hochhauser
Speaker
Dr Marc Mansour is an honorary consultant haematologist at University College London Hospital and leader of the Leukaemia Biology Research Group at UCL Cancer Institute. Dr Mansour has a long-standing interest in the biology of ALL and AML, particularly on the role of non-coding DNA in oncogene regulation. He has created several zebrafish models to study novel leukaemia oncogenes and tumour suppressors, with a particular focus on using these models to exploit the principal of synthetic lethality. This is based on the concept that, unlike normal cells, deficiency of tumour-suppressor genes in cancer cells creates a dependency on certain other genes for cell survival. Targeting these other genes with drugs should allow killing of tumour cells, while leaving normal cells unharmed.