Cancer Institute Seminar Series - Prof Daniel Bose

Enhancers are non-coding, genetic regulatory sequences that control cell-lineage and stimulus-specific transcription. It is now well established that enhancers can be transcribed into non-coding enhancer RNAs (eRNAs), and that eRNAs are important for regulating gene expression. Here we demonstrate that eRNAs can directly regulate the expression of enhancer associated genes by directing post-translational chromatin modifications.  eRNAs interact with the key transcription co-activator CBP at enhancers across the genome, and through this interaction stimulate the catalytic activity of CBP to promote histone acetylation and transcription of enhancer associated genes. 

Hosted by Dr Marc Mansour

A light lunch will be served after the seminar

This event has been sponsored in part by the Biomedical Research Centre and Cancer Research UK