UCL Cancer Institute


Cancer Institute Seminar Series - Prof Daniel Bose

01 November 2018, 12:00 pm–1:00 pm

eRNAs bind to the key transcription co-activator CBP, stimulating the acetyltransferase activity and promoting histone acetylation and transcription

Professor Daniel Bose, University of Sheffield presents: 'Enhancer RNAs: regulators of histone acetylation and transcription.'

Event Information

Open to



Veronica Dominguez


Courtyard Cafe
UCL Cancer Institute 72 Huntley Street

Enhancers are non-coding, genetic regulatory sequences that control cell-lineage and stimulus-specific transcription. It is now well established that enhancers can be transcribed into non-coding enhancer RNAs (eRNAs), and that eRNAs are important for regulating gene expression. Here we demonstrate that eRNAs can directly regulate the expression of enhancer associated genes by directing post-translational chromatin modifications.  eRNAs interact with the key transcription co-activator CBP at enhancers across the genome, and through this interaction stimulate the catalytic activity of CBP to promote histone acetylation and transcription of enhancer associated genes. 

Hosted by Dr Marc Mansour

A light lunch will be served after the seminar

This event has been sponsored in part by the Biomedical Research Centre and Cancer Research UK

About the Speaker

Daniel Bose

at University of Sheffield

Department of Molecular Biology and Biotechnology

Bose Lab