Aims
- To identify determinants of established risk factors for cardiovascular disease (CVD).
- To contribute to the discovery and validation of biological mechanisms that lead to CVD events, providing insight into prevention and treatment.
Current Objectives
Cause of causes:
- To establish which attributes of neighbourhood environment affect physical activity.
- To investigate whether social participation and networks are important determinants of physical activity.
Biological pathways using quantitative metabolomics:
- Identify metabolomic pathways that link diabetes with macro-vascular events.
- Expand the knowledge of causal pathways associated with coronary heart disease, stroke, and DVT/PE.
Risk Prediction:
- Test performance change in established predictive models for CHD/Stroke following the addition of a sub-set of biomarkers.
- To construct risk-scores for DVT/Pulmonary Embolism in the general population.
Genetics of metabolomic traits and instrument for Mendelian Randomisation:
- To expand and replicate the genetic determinants of the NMR-metabolomic traits necessary for future Mendelian Randomisation studies.
- To continue our collaboration with the UCLEB Consortium to co-lead MR experiments for drug target discovery and for environmental exposures.
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