Neuroscience, Physiology and Pharmacology


Prof Troy Margrie

Prof Troy Margrie


21 University Street


  • Professor of Systems Neuroscience and Associate Director
    The Sainsbury Wellcome Centre
    Faculty of Life Sciences

Joined UCL


Research Themes

Information about the world around us is gathered by our sensory organs and relayed to the brain, where it is processed and integrated by neuronal circuits. Such stimulus-related network activity is thought to represent an organism's external world and underlie cognitive processing and the generation of motor output. Our major aim is to determine the ways in which synaptic potentials, oscillatory rhythms and plasticity within neural circuits contribute to the representation and processing of the necessary information. We combine genetics, physiology, behavior and theory to examine the integrative elements that are involved in processing at various levels of sensory pathway. More specifically we use behavioral techniques in mice to determine the temporal constraints of olfactory processing. Subtle genetic manipulations of the olfactory circuit allows us to monitor in vivo the contribution of specific assemblies of cells to odor discrimination. Secondly we use in vivo recordings from individual and multiple cells in the cortex to investigate how information arriving from different sensory modalities influence the representation of a given sensory stimulus.
Award year Qualification Institution
1998 PhD
Doctor of Philosophy
University of Newcastle
1994 BSc Hons
Bachelor of Science (Honours)
University of Newcastle


Behaviour|*|Brain imaging|*|Brain slice physiology|*|Coding|*|Cognition|*|Computational modeling|*|Electrophysiological recording techniques|*|Extracellular recording - acute|*|Extracellular recording - chronic|*|Genetically encoded reporters/indicators Image analysis|*|Hearing and balance|*|Interneurons|*|Multi-photon imaging|*|Neocortex|*|Neural Circuits/Networks|*|Neuroanatomical approaches|*|Neuroimaging|*|Neuron|*|Neuronal mechanisms of sensation|*|Not clinically oriented research|*|Olfaction|*|Operant conditioning|*|Patch-clamp recording|*|Psychophysics|*|Synapse|*|Viral vectors