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SMB’s Alan Lowe receives BBSRC award to investigate cell competition phenomenon

18 October 2018

Reverse engineering cell competition using automated microscopy and recurrent neural networks

Congratulations to Dr Alan Lowe (research profile) who was successful in obtaining a BBSRC grant "Reverse engineering cell competition using automated microscopy and recurrent neural networks" as part of the "Machine learning to generate new biological understanding 2018" call.

The aim of this project is to use state-of-the-art artificial intelligence (AI), automated time-lapse microscopy, and proteomics to understand cell competition. Cell competition is a phenomenon that results in the elimination of less fit cells from a tissue - a critical process in development, homeostasis and disease. The group will develop an AI approach to extract time-dependent features of a single-cell's environment that predict its fate in biochemical and mechanical competition.

The programme is a collaborative award between groups at the Institute of Structural and Molecular Biology (ISMB), London Centre for Nanotechnology (LCN) and the Institute for the Physics of Living Systems (IPLS).