CDB Seminar Series - Professor Ewa Paluch - 28 February 2019

Start: Feb 28, 2019 01:00 PM
End: Feb 28, 2019 02:00 PM

CDB logo

Title: "Cross-talk between cell mechanics, cell shape and cell fate"
Speaker: Professor Ewa Paluch - Professor of Cell Biophysics, MRC/UCL Lab for Molecular Cell Biology (research profile)
Venue: JZ Young LT, Anatomy Building (map)
Host: Dr Masa Tada (email)

Abstract: A precise control of cell morphology is key for cell physiology, and cell shape deregulation is at the heart of many pathological disorders, including cancer. Cell morphology is intrinsically controlled by mechanical forces acting on the cell surface. We investigate how cellular mechanical properties are regulated, and how this regulation drives cellular shape changes.
Cell fate transitions are often associated with changes in cell shape, and strong evidence points to the existence of feedbacks between mechanics, morphology and fate decisions. We have recently started investigating the interplay between cell surface mechanics and fate transitions using mouse embryonic stem cells as a model system.