This group has focused on Antiphospholipid Syndrome and Systemic Lupus Erythematosus, studying these diseases using a novel, inter-disciplinary approach at UCL Biochemical Engineering
Molecular Studies of Beta-2-Glycoprotein I
Beta-2-Glycoprotein I is the main autoantigen of Antiphospholipid Syndrome (APS). It has a number of different roles in the body, from complement and coagulation regulation to scavenging LPS and even a proposed role in melanoma metastasis. Despite these roles, relatively little is known about this structure. This project has been funded by both APS Support UK and a Fellowship from the Medical Research Foundation. It has highlighted a number of interesting findings which have been published and presented internationally. It is still ongoing and through the application of complex methods, we aim to get a better understanding of why APS patients develop autoantibodies to B2GPI and how that process could be influenced therapeutically.
The McDonnell Lab has been developing novel methods of autoantibody detection for a number of years. Most recently, a methodology for the identification, purification and quantification of novel autoantibodies in various disease settings has been established. This has led to the detection of several novel autoantibodies in a number of diseases for which publications are in process. We are keen to translate our methods to a wider range of diseases by fostering further national and international collaborations.
Chronic Histiocytic Intervillositis
This is the PhD project of Dr Cornish. Chronic Histiocytic Intervillositis (CHI) is a rare placental disorder which leads to recurrent miscarriage. The aetiology is currently unknown, although it is believed to be an immune response to pregnancy. Dr Cornish’s project focuses on finally understanding what it is that drives this condition and how we can best combat it for the good of patients. This project is Co-Supervised by Prof. David Williams in the Institute of Women’s Health.
Study of Serine Proteases
In collaboration with Prof. Giles in the Division of Medicine, the McDonnell laboratory has undertaken significant studies looking into the structural implications of anti-serine protease autoantibodies. Antibodies to both Factor Xa and Thrombin (aFXa and aThr) are positive in up to 40% of APS and SLE patients. The clinical value of these autoantibodies is unknown, as is the potential pathogenic mechanism. The McDonnell laboratory has purified these antibodies and developed a number of different methods to test their activity and potential for structural change. These results been presented internationally at the ACR in America and BSR in the UK and are currently undergoing preparation for publication.