Centre for Anaesthesia Critical Care & Pain Medicine


Dr John Whittle FRCA FFICM MD

Consultant in Anaesthesia, Critical Care + Perioperative Medicine, UCLH
Hon Associate Professor, UCL
Lead For Perioperative Prehabilitation and Human Physiology and Performance Laboratory, UCL

Prehabilitaion Lead

Autonomic function and its influence on outcomes post sepsis and perioperatively

Neuroimmune interactions


Selected Publications

Whittle, J., & San-Millán, I. (2021). Objective assessment of metabolism and guidance of ICU rehabilitation with cardiopulmonary exercise testing.. Curr Opin Crit Care. doi:10.1097/MCC.0000000000000843

Gunnarsdottir, G. M., Helgadottir, S., Einarsson, S. G., Hreinsson, K., Whittle, J., Karason, S., & Sigurdsson, M. I. (2021). Validation of The Hospital Frailty Risk Score in Older Surgical Patients: a population-based retrospective cohort study.. Acta Anaesthesiol Scand. doi:10.1111/aas.13837

Lenk, T. A., Whittle, J., Aronson, S., Miller, T. E., Fuller, M., & Setji, T. (2021). Duke University Medical Center Perioperative Diabetes Management Program. Clinical Diabetes39(2), 208-214. doi:10.2337/cd20-0029

Whittle, J., Molinger, J., MacLeod, D., Haines, K., & Wischmeyer, P. E. (2020). Persistent hypermetabolism and longitudinal energy expenditure in critically ill patients with COVID-19. CRITICAL CARE24(1). doi:10.1186/s13054-020-03286-7

Molinger, J., Pastva, A. M., Whittle, J., & Wischmeyer, P. E. (2020). Novel approaches to metabolic assessment and structured exercise to promote recovery in ICU survivors. Current Opinion in Critical CarePublish Ahead of Print. doi:10.1097/mcc.0000000000000748

Grimberg, D. C., Shah, A., Molinger, J., Whittle, J., Gupta, R. T., Wischmeyer, P. E., . . . Inman, B. A. (2020). Assessments of frailty in bladder cancer. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS38(9), 698-705. doi:10.1016/j.urolonc.2020.04.036

Martin, G. S., Kaufman, D. A., Marik, P. E., Shapiro, N. I., Levett, D. Z. H., Whittle, J., . . . Miller, T. E. (2020). Perioperative Quality Initiative (POQI) consensus statement on fundamental concepts in perioperative fluid management: fluid responsiveness and venous capacitance. Perioperative Medicine9(1). doi:10.1186/s13741-020-00142-8

Ohnuma, T., Raghunathan, K., Ellis, A. R., Whittle, J., Pyati, S., Bryan, W. E., . . . Krishnamoorthy, V. (2020). Effects of Acetaminophen, NSAIDs, Gabapentinoids, and Their Combinations on Postoperative Pulmonary Complications After Total Hip or Knee Arthroplasty. PAIN MEDICINE21(10), 2385-2393. doi:10.1093/pm/pnaa017

Ackland, G. L., Abbott, T. E. F., Jones, T. F., Leuwer, M., & Pearse, R. M. (2020). Early elevation in plasma high-sensitivity troponin T and morbidity after elective noncardiac surgery: prospective multicentre observational cohort study. BRITISH JOURNAL OF ANAESTHESIA124(5), 535-543. doi:10.1016/j.bja.2020.02.003

Dunkman, W. J., Manning, M. W., Whittle, J., Hunting, J., Rampersaud, E. N., Inman, B. A., . . . Miller, T. E. (2019). Impact of an enhanced recovery pathway on length of stay and complications in elective radical cystectomy: a before and after cohort study. PERIOPERATIVE MEDICINE8(1), 10 pages. doi:10.1186/s13741-019-0120-4

Ackland, G. L., Abbott, T. E. F., Cain, D., Edwards, M. R., Sultan, P., Karmali, S. N., Whittle, J,  . . . Pearse, R. M. (2019). Preoperative systemic inflammation and perioperative myocardial injury: prospective observational multicentre cohort study of patients undergoing non-cardiac surgery. BRITISH JOURNAL OF ANAESTHESIA122(2), 180-187. doi:10.1016/j.bja.2018.09.002

Ackland, G. L., Abbott, T. E. F., Minto, G., Clark, M., Owen, T., Prabhu, P., Whittle, J  . . . Montague, L. (2019). Heart rate recovery and morbidity after noncardiac surgery: Planned secondary analysis of two prospective, multi-centre, blinded observational studies. PLOS ONE14(8), 15 pages. doi:10.1371/journal.pone.0221277

Whittle, J., Wischmeyer, P. E., Grocott, M. P. W., & Miller, T. E. (2018). Surgical Prehabilitation: Nutrition and Exercise. Anesthesiology Clinics36(4), 567-580. doi:10.1016/j.anclin.2018.07.013

Ackland, G. L., Minto, G., Clark, M., Whittle, J., Stephens, R. C. M., Owen, T., . . . del Arroyo, A. G. (2018). Autonomic regulation of systemic inflammation in humans: A multi-center, blinded observational cohort study. BRAIN BEHAVIOR AND IMMUNITY67, 47-53. doi:10.1016/j.bbi.2017.08.010

Machhada, A., Trapp, S., Marina, N., Stephens, R. C. M., Whittle, J., Lythgoe, M. F., . . . Gourine, A. V. (2017). Vagal determinants of exercise capacity.. Nature communications8, 15097. doi:10.1038/ncomms15097

Ackland, G. L., Whittle, J., Toner, A., Machhada, A., Del Arroyo, A. G., Sciuso, A., . . . Gourine, A. V. (2016). Molecular Mechanisms Linking Autonomic Dysfunction and Impaired Cardiac Contractility in Critical Illness. CRITICAL CARE MEDICINE44(8), E614-E624. doi:10.1097/CCM.0000000000001606

Nelson, A., Otto, J., Whittle, J., Stephens, R. C., Martin, D. S., Prowle, J. R., & Ackland, G. L. (2016). Subclinical cardiopulmonary dysfunction in stage 3 chronic kidney disease.. Open heart3(1), e000370. doi: 10.1136/openhrt-2015-000370

Edwards, M. R., Sultan, P., del Arroyo, A. G., Whittle, J., Karmali, S. N., Moonesinghe, S. R., . . . Ackland, G. L. (2015). Metabolic dysfunction in lymphocytes promotes postoperative morbidity. CLINICAL SCIENCE129(5), 423-437. doi:10.1042/CS20150024

Whittle, J., Nelson, A., Otto, J. M., Stephens, R. C. M., Martin, D. S., Sneyd, J. R., . . . Ackland, G. L. (2015). Sympathetic autonomic dysfunction and impaired cardiovascular performance in higher risk surgical patients: implications for perioperative sympatholysis.. Open Heart2(1), e000268. doi:10.1136/openhrt-2015-000268

Whittle, J., & Kelleher, A. A. (2015). Preoperative assessment for cardiac surgery. Anaesthesia and Intensive Care Medicine16(10), 484-490. doi:10.1016/j.mpaic.2015.07.009

Barsukevich, V., Basalay, M., Sanchez, J., Mrochek, A., Whittle, J., Ackland, G. L., . . . Gourine, A. (2015). Distinct cardioprotective mechanisms of immediate, early and delayed ischaemic postconditioning. BASIC RESEARCH IN CARDIOLOGY110(1), 11 pages. doi:10.1007/s00395-014-0452-7

Ackland, G. L., Iqbal, S., Paredes, L. G., Toner, A., Lyness, C., Jenkins, N., Whittle, J., . . . POM-O (PostOperative Morbidity-Oxygen delivery) study group. (2015). Individualised oxygen delivery targeted haemodynamic therapy in high-risk surgical patients: a multicentre, randomised, double-blind, controlled, mechanistic trial.. Lancet Respir Med3(1), 33-41. doi:10.1016/S2213-2600(14)70205-X

Botto, F., Alonso-Coello, P., Chan, M. T. V., Villar, J. C., Xavier, D., Srinathan, S., . . . Vascular events In noncardiac Surgery patIents cOhort evaluatioN VISION Study Investigators. (2014). Myocardial injury after noncardiac surgery: a large, international, prospective cohort study establishing diagnostic criteria, characteristics, predictors, and 30-day outcomes.. Anesthesiology120(3), 564-578. doi:10.1097/ALN.0000000000000113



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