| Selected Publications | Whittle, J., & San-Millán, I. (2021). Objective assessment of metabolism and guidance of ICU rehabilitation with cardiopulmonary exercise testing.. Curr Opin Crit Care. doi:10.1097/MCC.0000000000000843
Gunnarsdottir, G. M., Helgadottir, S., Einarsson, S. G., Hreinsson, K., Whittle, J., Karason, S., & Sigurdsson, M. I. (2021). Validation of The Hospital Frailty Risk Score in Older Surgical Patients: a population-based retrospective cohort study.. Acta Anaesthesiol Scand. doi:10.1111/aas.13837
Lenk, T. A., Whittle, J., Aronson, S., Miller, T. E., Fuller, M., & Setji, T. (2021). Duke University Medical Center Perioperative Diabetes Management Program. Clinical Diabetes, 39(2), 208-214. doi:10.2337/cd20-0029
Whittle, J., Molinger, J., MacLeod, D., Haines, K., & Wischmeyer, P. E. (2020). Persistent hypermetabolism and longitudinal energy expenditure in critically ill patients with COVID-19. CRITICAL CARE, 24(1). doi:10.1186/s13054-020-03286-7
Molinger, J., Pastva, A. M., Whittle, J., & Wischmeyer, P. E. (2020). Novel approaches to metabolic assessment and structured exercise to promote recovery in ICU survivors. Current Opinion in Critical Care, Publish Ahead of Print. doi:10.1097/mcc.0000000000000748
Grimberg, D. C., Shah, A., Molinger, J., Whittle, J., Gupta, R. T., Wischmeyer, P. E., . . . Inman, B. A. (2020). Assessments of frailty in bladder cancer. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 38(9), 698-705. doi:10.1016/j.urolonc.2020.04.036
Martin, G. S., Kaufman, D. A., Marik, P. E., Shapiro, N. I., Levett, D. Z. H., Whittle, J., . . . Miller, T. E. (2020). Perioperative Quality Initiative (POQI) consensus statement on fundamental concepts in perioperative fluid management: fluid responsiveness and venous capacitance. Perioperative Medicine, 9(1). doi:10.1186/s13741-020-00142-8
Ohnuma, T., Raghunathan, K., Ellis, A. R., Whittle, J., Pyati, S., Bryan, W. E., . . . Krishnamoorthy, V. (2020). Effects of Acetaminophen, NSAIDs, Gabapentinoids, and Their Combinations on Postoperative Pulmonary Complications After Total Hip or Knee Arthroplasty. PAIN MEDICINE, 21(10), 2385-2393. doi:10.1093/pm/pnaa017
Ackland, G. L., Abbott, T. E. F., Jones, T. F., Leuwer, M., & Pearse, R. M. (2020). Early elevation in plasma high-sensitivity troponin T and morbidity after elective noncardiac surgery: prospective multicentre observational cohort study. BRITISH JOURNAL OF ANAESTHESIA, 124(5), 535-543. doi:10.1016/j.bja.2020.02.003
Dunkman, W. J., Manning, M. W., Whittle, J., Hunting, J., Rampersaud, E. N., Inman, B. A., . . . Miller, T. E. (2019). Impact of an enhanced recovery pathway on length of stay and complications in elective radical cystectomy: a before and after cohort study. PERIOPERATIVE MEDICINE, 8(1), 10 pages. doi:10.1186/s13741-019-0120-4
Ackland, G. L., Abbott, T. E. F., Cain, D., Edwards, M. R., Sultan, P., Karmali, S. N., Whittle, J, . . . Pearse, R. M. (2019). Preoperative systemic inflammation and perioperative myocardial injury: prospective observational multicentre cohort study of patients undergoing non-cardiac surgery. BRITISH JOURNAL OF ANAESTHESIA, 122(2), 180-187. doi:10.1016/j.bja.2018.09.002
Ackland, G. L., Abbott, T. E. F., Minto, G., Clark, M., Owen, T., Prabhu, P., Whittle, J . . . Montague, L. (2019). Heart rate recovery and morbidity after noncardiac surgery: Planned secondary analysis of two prospective, multi-centre, blinded observational studies. PLOS ONE, 14(8), 15 pages. doi:10.1371/journal.pone.0221277
Whittle, J., Wischmeyer, P. E., Grocott, M. P. W., & Miller, T. E. (2018). Surgical Prehabilitation: Nutrition and Exercise. Anesthesiology Clinics, 36(4), 567-580. doi:10.1016/j.anclin.2018.07.013
Ackland, G. L., Minto, G., Clark, M., Whittle, J., Stephens, R. C. M., Owen, T., . . . del Arroyo, A. G. (2018). Autonomic regulation of systemic inflammation in humans: A multi-center, blinded observational cohort study. BRAIN BEHAVIOR AND IMMUNITY, 67, 47-53. doi:10.1016/j.bbi.2017.08.010
Machhada, A., Trapp, S., Marina, N., Stephens, R. C. M., Whittle, J., Lythgoe, M. F., . . . Gourine, A. V. (2017). Vagal determinants of exercise capacity.. Nature communications, 8, 15097. doi:10.1038/ncomms15097
Ackland, G. L., Whittle, J., Toner, A., Machhada, A., Del Arroyo, A. G., Sciuso, A., . . . Gourine, A. V. (2016). Molecular Mechanisms Linking Autonomic Dysfunction and Impaired Cardiac Contractility in Critical Illness. CRITICAL CARE MEDICINE, 44(8), E614-E624. doi:10.1097/CCM.0000000000001606
Nelson, A., Otto, J., Whittle, J., Stephens, R. C., Martin, D. S., Prowle, J. R., & Ackland, G. L. (2016). Subclinical cardiopulmonary dysfunction in stage 3 chronic kidney disease.. Open heart, 3(1), e000370. doi: 10.1136/openhrt-2015-000370
Edwards, M. R., Sultan, P., del Arroyo, A. G., Whittle, J., Karmali, S. N., Moonesinghe, S. R., . . . Ackland, G. L. (2015). Metabolic dysfunction in lymphocytes promotes postoperative morbidity. CLINICAL SCIENCE, 129(5), 423-437. doi:10.1042/CS20150024
Whittle, J., Nelson, A., Otto, J. M., Stephens, R. C. M., Martin, D. S., Sneyd, J. R., . . . Ackland, G. L. (2015). Sympathetic autonomic dysfunction and impaired cardiovascular performance in higher risk surgical patients: implications for perioperative sympatholysis.. Open Heart, 2(1), e000268. doi:10.1136/openhrt-2015-000268
Whittle, J., & Kelleher, A. A. (2015). Preoperative assessment for cardiac surgery. Anaesthesia and Intensive Care Medicine, 16(10), 484-490. doi:10.1016/j.mpaic.2015.07.009
Barsukevich, V., Basalay, M., Sanchez, J., Mrochek, A., Whittle, J., Ackland, G. L., . . . Gourine, A. (2015). Distinct cardioprotective mechanisms of immediate, early and delayed ischaemic postconditioning. BASIC RESEARCH IN CARDIOLOGY, 110(1), 11 pages. doi:10.1007/s00395-014-0452-7
Ackland, G. L., Iqbal, S., Paredes, L. G., Toner, A., Lyness, C., Jenkins, N., Whittle, J., . . . POM-O (PostOperative Morbidity-Oxygen delivery) study group. (2015). Individualised oxygen delivery targeted haemodynamic therapy in high-risk surgical patients: a multicentre, randomised, double-blind, controlled, mechanistic trial.. Lancet Respir Med, 3(1), 33-41. doi:10.1016/S2213-2600(14)70205-X
Botto, F., Alonso-Coello, P., Chan, M. T. V., Villar, J. C., Xavier, D., Srinathan, S., . . . Vascular events In noncardiac Surgery patIents cOhort evaluatioN VISION Study Investigators. (2014). Myocardial injury after noncardiac surgery: a large, international, prospective cohort study establishing diagnostic criteria, characteristics, predictors, and 30-day outcomes.. Anesthesiology, 120(3), 564-578. doi:10.1097/ALN.0000000000000113
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