Neural development and plasticity
William D Richardson PhD FMedSci FRS
tel +44 (0)20 7679 6729
Alison Kelly firstname.lastname@example.org
lab manager: Matthew Grist email@example.com
Cell-cell interactions in the developing central nervous system The vertebrate central nervous system (CNS) is immensely complicated, yet it has simple beginnings. The huge number and variety of cells in the mature CNS all develop from a much smaller number of precursor (stem) cells in the embryonic neural tube. Two of the central questions of neurodevelopment - and development in general - are: 1) How do stem cells select their future fates? 2) How do stem cells generate their differentiated progeny in correct numerical proportion to each other and to the size of the embryo as a whole? We are addressing these issues, focusing on the development of glial progenitor cells in the CNS. We take a multidisciplinary approach including primary cell culture, in situ methods and genetic manipulation in mice (e.g. Li et al., 2011, Tsai et al., 2012)
William D Richardson short CV
Tripathi, R.B., Rivers, L.E., Jamen, F. Young, K.M. and Richardson, W.D. (2010). NG2 glia generate new oligodendrocytes but few astrocytes in a murine experimental autoimmune encephalomyelitis model of demyelinating disease. J. Neurosci. 30, 16383-16390.
Zawadzka, M., Rivers, L., Fancy, S.P.J., Zhao, C., Tripathi, R., Jamen, F., Young, K.M.,Goncharevich, A., Pohl, H., Rizzi, M., Rowitch, D.H., Kessaris, N., Suter, U., *Richardson, W.D. and *Franklin, R.J.M. (2010). CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination. Cell Stem Cell 6, 578-590. * joint senior authors
L.E., Young, K.M., Rizzi, M., Jamen, F., Psachoulia, K.,
Wade, A., Kessaris, N. and Richardson, W.D. (2008).
PDGFRA/ NG2-positive glia generate myelinating
oligodendrocytes and piriform projection neurons in adult
mice. Nature Neuroscience 11, 1392-1401.