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Pedro Pereira's picture

Research Associate, Henriques Lab

p.pereira@ucl.ac.uk 

Europe PMC | PubMed | ORCID | Researchgate | Scopus

Research Synopsis

Most mammalian pathogens such as viruses, bacteria and protozoan parasites, exist and elicit interactions with host factors, at scales near or below the resolution limit of conventional light microscopy (~300nm). This drawback has critically limited the information obtained in infection-based imaging studies. Super-Resolution Localisation Microscopy (SMLM) methods such as Stochastic Optical Reconstruction Microscopy (STORM) hold the potential to resolve cellular structures at near-molecular scales (~1-30nm) in a non-destructive and molecularly specific manner. However, this family of approaches is still severely handicapped by 1) the complexity of high-speed experiments with minimal photo- or chemical-damage to the sample, and 2) the reduced number of fluorophores that can be adapted for multicolour Super-Resolution imaging. In the Quantitative Imaging and Nanobiophysics Group I’m applying my expertise in cell biology, biochemistry and my background as a chemist to develop new probes that overcome these challenges allowing to fully explore the potential of SMLM methods. We aim to apply these new developments to the study of how pathogens interact and overrun the host immune response in order to establish a successful infection. 

Biography

2013 | PhD in Cell Biology, New University of Lisbon, Portugal
2007 | Master in Biotechnology, New University of Lisbon, Portugal
2006 | Degree in Applied Chemistry, New University of Lisbon, Portugal
 

Awards

2013 | Jacqueline Dias de Sousa Foundation Award for best PhD thesis
2011 | Short term EMBO Fellowship
2008 | PhD Fellowship, Portuguese Foundation for Science and Technology

Funders

BBSRC

Research Themes

Cytoskeleton and cell cortex, Cell-cell interactions, Membrane trafficking, Viral pathogens

Technology

Light microscopy, Super-resolution microscopy, High throughput screening