Selected Recent Publications

Kipanyula, M. J., Woodhoo, A., Rahman, M., Payne, D., Jessen, K. R., & Mirsky, R. (2013). Calcineurin-nuclear factor of activated t cells regulation of Krox-20 expression in Schwann cells requires elevation of intracellular cyclic AMP. Journal of Neuroscience Research, 91(1), 105–115. doi:10.1002/jnr.23131

Peter J. Arthur-Farraj, Morwena Latouche, Daniel K. Wilton, Susanne Quintes, Elodie Chabrol, Ambily Banerjee, Ashwin Woodhoo, Billy Jenkins, Mary Rahman, Mark Turmaine, Grzegorz K. Wicher, Richard Mitter, Linda Greensmith, Axel Behrens, Gennadij Raivich, Rhona Mirsky, and Kristjan R. Jessen (2012). c-Jun Reprograms Schwann Cells of Injured Nerves to Generate a Repair Cell Essential for Regeneration. Neuron, 75, 633-647.

Hutton, E. J., Carty, L., Laurá, M., Houlden, H., Lunn, M. P. T., Brandner, S., Mirsky, R., Jessen KR, Reilly MM (2011). c-Jun expression in human neuropathies: a pilot study. Journal of the peripheral nervous system. JPNS, 16, 295–303.

Arthur-Farraj P, Wanek K, Hantke J, Davis CM, Jayakar A, Parkinson DB, Mirsky R, Jessen KR (2011). Mouse schwann cells need both NRG1 and cyclic AMP to myelinate. Glia 59:720-33.

Jessen KR, Mirsky R. Control of Schwann cell myelination. F1000 Biol Rep. Mar 15;2. pii: 19.. (2009)

Woodhoo A, Duran Alonso MB, Droggiti A, Turmaine M, D’Antonio M, Parkinson DB, Wilton DK, R Al-Shawi, P Simons, J Shen, F Guillemot, F Radtke, Meijer D, Feltri ML, Wrabetz L, Mirsky R, Jessen KR. (2009)  Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity. Nature Neurosci 12: 839-847.

Jessen KR, Mirsky R.(2008) Negative regulation of myelination: relevance for development, injury, and demyelinating disease. Glia 56:1552-65.

Jessen KR, Mirsky R., & Salzer, J. (2008) Introduction. Schwann cell biology. Glia 56:1479-80.

Mirsky R and Jessen KR Development of Schwann cells. In: The New Encyclopedia of Neuroscience, Elsevier on-line.

Mirsky R, Woodhoo A, Parkinson DB, Arthur-Farraj P, Bhaskaran A and Jessen KR (2008) Novel signals controlling embryonic Schwann cell development, myelination and dedifferentiation. J Peripher Nerv Syst 13:122-135.

Agudo M, Woodhoo A, Webber D, Mirsky R, Jessen KR and McMahon SB (2008) Schwann cell precursors transplanted into the injured spinal cord multiply, integrate and are permissive for axon growth. Glia 56:1263-1270.

Parkinson DB, Bhaskaran A, Arthur-Farraj P, Noon LA, Woodhoo A, Lloyd AC, Feltri ML, Wrabetz L, Behrens A, Mirsky R and Jessen KR (2008) c-Jun is a negative regulator of myelination. J Cell Biol 181:625-637.

Mirsky R and Jessen KR (2007) Early events in Schwann cell development. In: The Biology of Schwann Cells – Development, Differentiation and Immunomodulation, ed Armati PJ, Cambridge University Press, Chapter 2, pp.13-36.

Woodhoo A, Sahni V, Gilson J, Setzu A, Franklin RJM, Blakemore WF, Mirsky R and Jessen KR (2007) Schwann cell precursors: a favourable cell for myelin repair in the Central Nervous System. Brain 130:2175-2185.

D’Antonio M, Droggiti A, Feltri ML, Roes J, Wrabetz L, Mirsky R and Jessen KR (2006) TGFß type II receptor signaling controls Schwann cell death and proliferation in developing nerves. J Neurosci 26:8417-8427.

Arthur-Farraj P, Mirsky R, Parkinson DB and Jessen KR (2006) A double point mutation in the DNA-binding region of Egr2 switches its function from inhibition to induction of proliferation: A potential contribution to the development of congenital hypomyelinating neuropathy. Neurobiol Dis 24:159-169.

Kazakova N, Li H, Mora A, Jessen KR, Mirsky R, Richardson WD and Smith HK (2006) A screen for mutations in zebrafish that affect myelin gene expression in Schwann cells and oligodendrocytes. Dev Biol 297:1-13.

Wanner IB, Guerra NK, Mahoney J, Kumar A, Wood PM, Mirsky R and Jessen KR (2006) Role of N-cadherin in Schwann cell precursors of growing nerves. Glia 54:439-459.

Wanner IB, Mahoney J, Jessen KR, Wood PM, Bates M and Bunge MB (2006) Invariant mantling of growth cones by Schwann cell precursors characterize growing peripheral nerve fronts. Glia 54:424-438.

Jessen KR (2006) A brief look at glial cells. Novartis Foundation Symposium, Purinergic Signalling in Neurone-Glia Interactions. John Wiley & Sons Ltd, USA 276:5-14.

Sharghi-Namini S, Turmaine M, Meier C, Sahni V, Umehara F, Jessen KR and Mirsky R (2006) The structural and functional integrity of peripheral nerves depends on the glial-derived signal desert hedgehog. J Neurosci 26:6364-6376. (please contact Debbie Bartram at the address below if you have problems accessing the whole of this paper)

D’Antonio M, Michalovich D, Paterson M, Droggiti A, Woodhoo A, Mirsky R and Jessen KR (2006) Gene profiling and bioinformatic analysis of Schwann cell embryonic development and myelination. Glia 53:501-515.

Bajestan SN, Umehara F, Shirahama Y, Itoh K, Sharghi-Namini S, Jessen KR, Mirsky R and Osame M (2006) Desert hedgehog-patched 2 expression in peripheral nerves during Wallerian degeneration and regeneration. J Neurobiol 66:243-255.

Jessen KR and Mirsky R (2005) The origin and development of glial cells in peripheral nerves. Nat Rev Neurosci 6:671-682.

Parkinson DB, Bhaskaran A, Mirsky R and Jessen KR (2005) Regulation of the myelinating phenotype of Schwann cells by Krox-20. Medimond International Proceedings VII European Meeting on Glial Cell Function in Health and Disease, Amsterdam pp.139-143.

Mirsky R and Jessen KR (2005) Molecular signaling in Schwann cell development. In: Peripheral Neuropathy, 4th Edition, eds Dyck PJ and Thomas PK, Elsevier Press.

Jessen KR and Mirsky R (2005) The Schwann cell lineage. In: Neuroglia, 2nd Edition, eds Kettenmann H and Ransom B, Oxford University Press, pp.85-100.

Jessen KR and Mirsky R (2004) The developmental biology of the Schwann cell. In: Hereditary Leukoencephalopathies and Demyelinating Neuropathies in Children, eds Uziel G and Taroni F, John Libbey Eurotext, pp.23-35.

Meintanis S, Thomaidou D, Jessen KR, Mirsky R and Matsas R (2004) Novel method for studying myelination in vivo reveals that EDTA is a potent inhibitor of myelin protein and mRNA expression during development of the rat sciatic nerve. Glia 48:132-144.

Jessen KR (2004) Glial Cells. Int J Biochem Cell Biol 36:1861-1867.

Alonso MB, Zoidl G, Taveggia C, Bosse F, Zoidl C, Rahman M, Parmantier E, Dean CH, Harris BS, Wrabetz L, Müller HW, Jessen KR and Mirsky R (2004) Identification and characterization of ZFP-57, a novel zinc finger transcription factor in the mammalian peripheral nervous system. J Biol Chem 279:25653-25664.

Jessen KR and Mirsky R (2004) Schwann cell development. In: Myelin Biology and Disorders, Vol 1, ed Lazzarini RA, Elsevier Academic Press, USA, pp.329-370.

Woodhoo A, Dean CH, Droggiti A, Mirsky R and Jessen KR (2004) The trunk neural crest and its early glial derivatives: a study of survival responses, developmental schedules and autocrine mechanisms. Mol Cell Neurosci 25:30-41.

Parkinson DB, Bhaskaran A, Droggiti A, Dickinson S, D’Antonio M, Mirsky R and Jessen KR (2004) Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death. J Cell Biol 164:385-394.

Parkinson DB, Dickinson S, Bhaskaran A, Kinsella MT, Brophy PJ, Sherman DL, Sharghi-Namini S, Duran Alonso MB, Mirsky R and Jessen KR (2003) Regulation of the myelin gene periaxin provides evidence for Krox-20-independent myelin-related signalling in Schwann cells. Mol Cell Neurosci 23:13-27.

Tofaris GK, Patterson PH, Jessen KR and Mirsky R (2002) Denervated Schwann cells attract macrophages by secretion of LIF and MCP-1 in a process regulated by Il-6 and LIF. J Neurosci 22:6696-6703.

Jessen KR and Mirsky R (2002) Signals that determine Schwann cell identity. J Anat 200:367-376.

Parkinson DB, Langner K, Sharghi Namini S, Jessen KR and Mirsky R (2002) ß-neuregulin and autocrine mediated survival of Schwann cells requires activity of Ets family transcription factors. Mol Cell Neurosci 20:154-167.

Mirsky R, Jessen KR, Brennan A, Parkinson D, Dong Z, Meier C, Parmantier E and Lawson D (2002) Schwann cells as regulators of nerve development. J Physiol (Paris) 96:17-24.

Parkinson DB, Dong Z, Bunting H, Whitfield J, Meier C, Marie H, Mirsky R and Jessen KR (2001) Transforming growth factor ß (TGFß) mediates Schwann cell death in vitro and in vivo: examination of c-Jun activation, interactions with survival signals, and the relationship of TGFß mediated death to Schwann cell differentiation. J Neurosci 21:8572-8585.

Mirsky R, Parkinson DB, Dong Z, Meier C, Calle E, Brennan A, Topilko P, Harris BS, Stewart HJS and Jessen KR (2001) Regulation of genes involved in Schwann cell development and differentiation. Prog Brain Res 132:3-11.

Stewart HJS, Brennan A, Rahman M, Zoidl G, Mitchell PJ, Jessen KR and Mirsky R (2001) Developmental regulation and overexpression of the transcription factor AP-2, a potential regulator of the timing of Schwann cell generation. Eur J Neurosci 14:363-372.

Meintanis S, Thomaidou D, Jessen KR, Mirsky R and Matsas R (2001) The neuron-glia signal ß-neuregulin promotes Schwann cell motility via the MAPK pathway. Glia 34:39-51.

Lee M-J, Calle E, Brennan A, Ahmed S, Sviderskaya E, Jessen KR and Mirsky R (2001) In early development of the rat mRNA for the major myelin protein P0 is expressed in nonsensory areas of the embryonic inner ear, notochord, enteric nervous system, and olfactory ensheathing cells. Dev Dyn 222:40-51.

Mirsky R and Jessen KR (2001) Embryonic and early postnatal development of Schwann cells. In: Glial Cell Development: basic principles and clinical relevance, 2nd Edition, eds Jessen KR and Richardson WD, Oxford University Press, pp.1-20.

Brennan A, Dean CH, Zhang AL, Cass DT, Mirsky R and Jessen KR (2000) Endothelins control the timing of Schwann cell generation in vitro and in vivo. Dev Biol 227:545-557.

Mirsky R, Parmantier E, McMahon AP and Jessen KR (1999) Schwann cell-derived desert hedgehog signals nerve sheath formation. Ann N Y Acad Sci 883:196-202.

Jessen KR, Meier C and Mirsky R (1999) Why do Schwann cells survive in the absence of axons? Ann N Y Acad Sci 883:109-115.

Parmantier E, Lynn B, Lawson D, Turmaine M, Sharghi Namini S, Chakrabarti L, McMahon AP, Jessen KR and Mirsky R (1999) Schwann cell-derived Desert Hedgehog controls the development of peripheral nerve sheaths. Neuron 23:713-724.

Jessen KR and Mirsky R (1999) Schwann cells and their precursors emerge as major regulators of nerve development. Trends Neurosci 22:402-410.

Meier C, Parmantier E, Brennan A, Mirsky R and Jessen KR (1999) Developing Schwann cells acquire the ability to survive without axons by establishing an autocrine circuit involving IGF, NT-3 and PDGF-BB. J Neurosci 19:3847-3859.

Dong Z, Sinanan A, Parkinson D, Parmantier E, Mirsky R and Jessen KR (1999) Schwann cell development in embryonic mouse nerves. J Neurosci Res 56:334-348.

Mirsky R and Jessen KR (1999) The neurobiology of Schwann cells. Brain Pathol 9:293-311.

Tabernero A, Stewart HJS, Jessen KR and Mirsky R (1998) The neuron-glia signal ß neuregulin induces sustained CREB phosphorylation on Ser-133 in cultured rat Schwann cells. Mol Cell Neurosci 10:309-322.

Lee M-J, Brennan A, Blanchard A, Zoidl G, Dong Z, Tabernero A, Zoidl C, Dent MAR, Jessen KR and Mirsky R (1997) P0 is constitutively expressed in the rat neural crest and embryonic nerves and is negatively and positively regulated by axons to generate non-myelin-forming and myelin-forming Schwann cells, respectively. Mol Cell Neurosci 8:336-350.

Blanchard AD, Sinanan A, Parmantier E, Zwart R, Broos L, Meijer D, Meier C, Jessen KR and Mirsky R (1996) Oct-6 (SCIP/Tst-1) is expressed in Schwann cell precursors, embryonic Schwann cells, and postnatal myelinating Schwann cells: Comparison with Oct-1, Krox-20 and Pax-3. J Neurosci Res 46:630-640.

Dong Z, Brennan A, Liu N, Yarden Y, Lefkowitz G, Mirsky R and Jessen KR (1995) NDF is a neuron-glia signal and regulates survival, proliferation, and maturation of rat Schwann cell precursors. Neuron 15:585-596.

Jessen KR, Brennan A, Morgan L, Mirsky R, Kent A, Hashimoto Y and Gavrilovic J (1994) The Schwann cell precursor and its fate: A study of cell death and differentiation during gliogenesis in rat embryonic nerves. Neuron 12:509-527.