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Institute of Epidemiology & Health Care

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Our Policy Impact

As of January 2024, 57 papers authored by at least one ECHO member were cited 67 times in 20 high-impact documents, such as national strategies; national or international white papers including by WHO, NAM (US) and Cancer Research UK; and Lancet Oncology Commissions. In 44 of these papers ECHO co-authors were first or last authors.

For our research themes and on-going research activity, as well as a collection of our recent publications, please view the Our Research page:

Our Research

 

Papers Published 2020 - 2023

2022

Publication:

McPhail S, Swann R, Johnson SA, et al. Risk factors and prognostic implications of diagnosis of cancer within 30 days after an emergency hospital admission (emergency presentation): an International Cancer Benchmarking Partnership (ICBP) population-based study. Lancet Oncol. 2022;23(5):587-600.

Cited in:

  • The Lancet Oncology Policy Review "The future of cancer care in the UK—time for a radical and sustainable National Cancer Plan". 2023

Forster, A.S., Herbert, A., Koo, M.M. et al. Associations between diagnostic time intervals and health-related quality of life, clinical anxiety and depression in adolescents and young adults with cancer: cross-sectional analysis of the BRIGHTLIGHT cohort. Br J Cancer 126, 1725–1734 (2022).

  • NIHR Alert: "Young people who have a long wait for a cancer diagnosis have reduced quality of life". 2023
2021

Publication:

Lai J, Mak V, Bright CJ, Lyratzopoulos G, Elliss-Brookes L, Gildea C. Reviewing the impact of 11 national Be Clear on Cancer public awareness campaigns, England, 2012 to 2016: A synthesis of published evaluation results. Int J Cancer. 2021 Mar 1;148(5):1172-1182.

Cited in:

  • The Lancet Oncology Policy Review "The future of cancer care in the UK—time for a radical and sustainable National Cancer Plan". 2023
  • Cancer Research UK: "Longer, Better Lives; A programme for UK government for cancer research and care". 2023

Barclay ME, Abel GA, Greenberg DC, Rous B, Lyratzopoulos G. Socio-demographic variation in stage at diagnosis of breast, bladder, colon, endometrial, lung, melanoma, prostate, rectal, renal and ovarian cancer in England and its population impact. Br J Cancer. 2021 Mar;124(7):1320-1329.

  • The Lancet Oncology Policy Review "The future of cancer care in the UK—time for a radical and sustainable National Cancer Plan". 2023

Herbert, A., Rafiq, M., Pham, T. M., Renzi, C., Abel, G. A., Price, S., Hamilton, W., Petersen, I., & Lyratzopoulos, G. (2021). Predictive values for different cancers and inflammatory bowel disease of 6 common abdominal symptoms among more than 1.9 million primary care patients in the UK: A cohort study. In S. Basu (Ed.), PLOS Medicine (Vol. 18, Issue 8, p. e1003708). Public Library of Science (PLoS).

  • NIHR Alert: "When do people with abdominal symptoms need a fast-track referral?" 2022
2020

Publication:

Koo MM, Swann R, McPhail S, Abel GA, Elliss-Brookes L, Rubin GP, Lyratzopoulos G. Presenting symptoms of cancer and stage at diagnosis: evidence from a cross-sectional, population-based study. Lancet Oncol. 2020 Jan;21(1):73-79.

Cited in:

  • WHO report: "Cancer: Setting Priorities, Investing Wisely, and Providing Care for All". 2020
  • The Lancet Oncology Policy Review "The future of cancer care in the UK—time for a radical and sustainable National Cancer Plan". 2023

Koo MM, Lyratzopoulos G, Herbert A, et al. Association of Self-reported Presenting Symptoms With Timeliness of Help-Seeking Among Adolescents and Young Adults With Cancer in the BRIGHTLIGHT Study. JAMA Netw Open. 2020;3(9):e2015437

  • NIHR Alert: "Young people who have a long wait for a cancer diagnosis have reduced quality of life". 2023

R. Swann, G. Lyratzopoulos, G. Rubin, E. Pickworth and S. McPhail, “The frequency, nature and impact of GP-assessed avoidable delays in a population-based cohort of cancer patients,” Cancer Epidemiol, vol. 64, p. 101617, February 2020.

  • Cancer Research UK: "Early Detection and Diagnosis of Cancer Roadmap". 2020

Fowler H, Belot A, Ellis L, Maringe C, Luque-Fernandez MA, Njagi EN, Navani N, Sarfati D, Rachet B. Comorbidity prevalence among cancer patients: a population-based cohort study of four cancers. BMC Cancer. 2020 Jan 28;20(1):2.

  • The Lancet Oncology Policy Review "The future of cancer care in the UK—time for a radical and sustainable National Cancer Plan". 2023

Ruth Swann, Georgios Lyratzopoulos, Greg Rubin, Elizabeth Pickworth, Sean McPhail. The frequency, nature and impact of GP-assessed avoidable delays in a population-based cohort of cancer patients, Cancer Epidemiology, Volume 64, 2020, 101617

  • Cancer Research UK: "Longer, Better Lives; A programme for UK government for cancer research and care". 2023

 

Papers Published 2017 - 2019

2019

Publication:

Pham TM, Gomez-Cano M, Salika T, Jardel D, Abel GA, Lyratzopoulos G. Diagnostic route is associated with care satisfaction independently of tumour stage: Evidence from linked English Cancer Patient Experience Survey and cancer registration data. Cancer Epidemiol. 2019 Aug;61:70-78.

Cited in:

  • Cancer Research UK report: "Cancer in the UK 2020: Socio-economic deprivation". 2020
  • Cancer Research UK: "Longer, Better Lives; A programme for UK government for cancer research and care". 2023

Walter FM, Thompson MJ, Wellwood I, Abel GA, Hamilton W, Johnson M, Lyratzopoulos G, Messenger MP, Neal RD, Rubin G, Singh H, Spencer A, Sutton S, Vedsted P, Emery JD. Evaluating diagnostic strategies for early detection of cancer: the CanTest framework. BMC Cancer. 2019 Jun 14;19(1):586.

  • Cancer Research UK: "Early Detection and Diagnosis of Cancer Roadmap". 2020

Herbert A, Abel GA, Winters S, McPhail S, Elliss-Brookes L, Lyratzopoulos G. Are inequalities in cancer diagnosis through emergency presentation narrowing, widening or remaining unchanged? Longitudinal analysis of English population-based data 2006-2013. J Epidemiol Community Health. 2019 Jan;73(1):3-10.

  • Cancer Research UK: "Longer, Better Lives; A programme for UK government for cancer research and care". 2023

Barclay ME, Abel GA, Elliss-Brookes L, Greenberg DC, Lyratzopoulos G. The influence of patient case mix on public health area statistics for cancer stage at diagnosis: a cross-sectional study. Eur J Public Health. 2019 Dec 1;29(6):1103-1107.

  • National Disease Registration Service 2021: Case-mix adjusted percentage of cancers diagnosed at stages 1 and 2 for Clinical Comissioning Groups in England (experiemental statistics). Public Health England technical document. 2021

Lyratzopoulos & Barclay, Acknowledgements. Case-mix adjusted percentage of cancers diagnosed at stages 1 and 2 by Clinical Commissioning Groups in England - NHS Digitial Technical document. 

  • National Disease Registration Service 2021: Case-mix adjusted percentage of cancers diagnosed at stages 1 and 2 for Clinical Comissioning Groups in England (experiemental statistics). Public Health England technical document. 2021
2018

Publication:

Henson KE, Fry A, Lyratzopoulos G, Peake M, Roberts KJ, McPhail S. Sociodemographic variation in the use of chemotherapy and radiotherapy in patients with stage IV lung, oesophageal, stomach and pancreatic cancer: evidence from population-based data in England during 2013-2014. Br J Cancer. 2018 May;118(10):1382-1390.

Cited in:

  • Cancer Research UK report: "Cancer in the UK 2020: Socio-economic deprivation". 2020

Herbert, A., Abel, G. A., Winters, S., McPhail, S., Elliss-Brookes, L., & Lyratzopoulos, G. (2018). Are inequalities in cancer diagnosis through emergency presentation narrowing, widening or remaining unchanged? Longitudinal analysis of English population-based data 2006-2013. Journal of Epidemiology and Community Health, 73, 3-10.

  • Cancer Research UK report: "Cancer in the UK 2020: Socio-economic deprivation". 2020

Swann R, McPhail S, Witt J, Shand B, Abel GA, Hiom S, Rashbass J, Lyratzopoulos G, Rubin G; National Cancer Diagnosis Audit Steering Group. Diagnosing cancer in primary care: results from the National Cancer Diagnosis Audit. Br J Gen Pract. 2018 Jan;68(666):e63-e72.

  • The Lancet Oncology Policy Review "The future of cancer care in the UK—time for a radical and sustainable National Cancer Plan". 2023

Henson, K.E., Fry, A., Lyratzopoulos, G. et al. Sociodemographic variation in the use of chemotherapy and radiotherapy in patients with stage IV lung, oesophageal, stomach and pancreatic cancer: evidence from population-based data in England during 2013–2014. Br J Cancer 118, 1382–1390 (2018).

  • Cancer Research UK: "Longer, Better Lives; A programme for UK government for cancer research and care". 2023

Barclay ME, Lyratzopoulos G, Greenberg DC, Abel GA. Missing data and chance variation in public reporting of cancer stage at diagnosis: Cross-sectional analysis of population-based data in England. Cancer Epidemiol. 2018 Feb;52:28-42.

  • National Disease Registration Service 2021: Case-mix adjusted percentage of cancers diagnosed at stages 1 and 2 for Clinical Comissioning Groups in England (experiemental statistics). Public Health England technical document. 2021

Annie Herbert, Georgios Lyratzopoulos, Jeremy Whelan, Rachel M Taylor, Julie Barber, Faith Gibson, Lorna A Fern, Diagnostic timeliness in adolescents and young adults with cancer: a cross-sectional analysis of the BRIGHTLIGHT cohort, The Lancet Child & Adolescent Health, Volume 2, Issue 3, 2018, Pages 180-190.

  • NIHR Alert: "Young people who have a long wait for a cancer diagnosis have reduced quality of life". 2023
2017

Publication:

Zhou Y, Abel GA, Hamilton W, Pritchard-Jones K, Gross CP, Walter FM, Renzi C, Johnson S, McPhail S, Elliss-Brookes L, Lyratzopoulos G. Diagnosis of cancer as an emergency: a critical review of current evidence. Nat Rev Clin Oncol. 2017 Jan;14(1):45-56.

Cited in:

  • Cancer Research UK: "Longer, Better Lives; A programme for UK government for cancer research and care". 2023

Abel GA, Mendonca SC, McPhail S, Zhou Y, Elliss-Brookes L, Lyratzopoulos G. Emergency diagnosis of cancer and previous general practice consultations: insights from linked patient survey data. Br J Gen Pract. 2017 Jun;67(659):e377-e387.

  • Cancer Research UK: "Early Detection and Diagnosis of Cancer Roadmap". 2020

 

Papers Published 2014 - 2016

2016

Publication:

Mendonca SC, Abel GA, Saunders CL, Wardle J, Lyratzopoulos G. Pre-referral general practitioner consultations and subsequent experience of cancer care: evidence from the English Cancer Patient Experience Survey. Eur J Cancer Care (Engl). 2016 May;25(3):478-90.

Cited in:

  • The Lancet Oncology Commission: "The Expanding Role of Primary Care in Cancer Control". 2015

Saunders CL, Elliott MN, Lyratzopoulos G, Abel GA. Do Differential Response Rates to Patient Surveys Between Organizations Lead to Unfair Performance Comparisons?: Evidence From the English Cancer Patient Experience Survey. Med Care. 2016 Jan;54(1):45-54.

  • CMS (US) Medicare Program: "Contract Year 2019 Policy and Technical Changes to the Medicare Advantage, Medicare Cos Plan, Medicare Fee-for-Service, the Medicare Prescription Drug Benefit Programs, and the PACE Program". 2019.

Lyratzopoulos, G. & Wellings, D. Redesigning the Cancer Patient Experience Survey. Blog, NHS England. 2016. URL: https://www.england.nhs.uk/blog/dan-wellings-2/

  • Macmillan Cancer Support: "Is case-mix adjustment important for the National Cancer Patient Experience Survey in England (CPES)? A summary". 2014
2015

Publication:

Lyratzopoulos G, Vedsted P, Singh H. Understanding missed opportunities for more timely diagnosis of cancer in symptomatic patients after presentation. Br J Cancer. 2015 Mar 31;112 Suppl 1(Suppl 1):S84-91.

Cited in:

  • U.S. Institute of Medicine Report" "Improving Diagnosis in Health Care". 2015
  • WHO report: "Narrative review of the WHO working party on the Global Burden of Diagnostic Errors in Primary Care". 2016

Renzi C, Whitaker KL, Wardle J. Over-reassurance and undersupport after a 'false alarm': a systematic review of the impact on subsequent cancer symptom attribution and help seeking. BMJ Open. 2015 Feb 4;5(2):e007002.

  • The Lancet Oncology Commission: "The Expanding Role of Primary Care in Cancer Control". 2015

Lyratzopoulos G, Liu MP, Abel GA, Wardle J, Keating NL. The Association between Fatalistic Beliefs and Late Stage at Diagnosis of Lung and Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2015 Apr;24(4):720-6.

  • The Lancet Oncology Commission: "The Expanding Role of Primary Care in Cancer Control". 2015

Rubin GP, Saunders CL, Abel GA, McPhail S, Lyratzopoulos G, Neal RD. Impact of investigations in general practice on timeliness of referral for patients subsequently diagnosed with cancer: analysis of national primary care audit data. Br J Cancer. 2015 Feb 17;112(4):676-87.

  • The Lancet Oncology Commission: "The Expanding Role of Primary Care in Cancer Control". 2015

Lyratzopoulos, G., Vedsted, P. & Singh, H. Understanding missed opportunities for more timely diagnosis of cancer in symptomatic patients after presentation. Br J Cancer 112 (Suppl 1), S84–S91 (2015). 

  • Cancer Research UK: "Early Detection and Diagnosis of Cancer Roadmap". 2020

Abel GA, Shelton J, Johnson S, Elliss-Brookes L, Lyratzopoulos G. Cancer-specific variation in emergency presentation by sex, age and deprivation across 27 common and rarer cancers. Br J Cancer. 2015 Mar 31;112 Suppl 1(Suppl 1):S129-36.

  • Cancer Research UK report: "Cancer in the UK 2020: Socio-economic deprivation". 2020
2014

Publication:

Lyratzopoulos G, Wardle J, Rubin G. Rethinking diagnostic delay in cancer: how difficult is the diagnosis? BMJ 2014; 349 :g7400

Cited in:

  • The Lancet Oncology Commission: "The Expanding Role of Primary Care in Cancer Control". 2015
  • WHO report: "Narrative review of the WHO working party on the Global Burden of Diagnostic Errors in Primary Care". 2016

Abel GA, Saunders CL, Lyratzopoulos G. Cancer patient experience, hospital performance and case mix: evidence from England. Future Oncol. 2014;10(9):1589-98.

  • Macmillan Cancer Support: "Is case-mix adjustment important for the National Cancer Patient Experience Survey in England (CPES)? A summary". 2014

 

Papers Published 2011 - 2013

2013

Publication:

Lyratzopoulos G, Abel GA, Brown CH, Rous BA, Vernon SA, Roland M, Greenberg DC. Socio-demographic inequalities in stage of cancer diagnosis: evidence from patients with female breast, lung, colon, rectal, prostate, renal, bladder, melanoma, ovarian and endometrial cancer. Ann Oncol. 2013 Mar;24(3):843-50.

Cited in:

  • National Cancer Strategy for England 2015-2020: Achieving World-Class Cancer Outcomes". 2015
  • Cancer Research UK: "Early Detection and Diagnosis of Cancer Roadmap". 2020
  • Cancer Research UK report: "Cancer in the UK 2020: Socio-economic deprivation". 2020

Paddison CA, Elliott MN, Haviland AM, Farley DO, Lyratzopoulos G, Hambarsoomian K, Dembosky JW, Roland MO. Experiences of care among Medicare beneficiaries with ESRD: Medicare Consumer Assessment of Healthcare Providers and Systems (CAHPS) survey results. Am J Kidney Dis. 2013 Mar;61(3):440-9.

  • CMS (US) Medicare Program: "Contract Year 2019 Policy and Technical Changes to the Medicare Advantage, Medicare Cos Plan, Medicare Fee-for-Service, the Medicare Prescription Drug Benefit Programs, and the PACE Program". 2019.

Lyratzopoulos G, Abel GA, McPhail S, et alGender inequalities in the promptness of diagnosis of bladder and renal cancer after symptomatic presentation: evidence from secondary analysis of an English primary care audit survey. BMJ Open 2013;3:e002861.

  • The Lancet Commission: "Women, power, and cancer", 2023

El Turabi A, Abel GA, Roland M, Lyratzopoulos G. Variation in reported experience of involvement in cancer treatment decision making: evidence from the National Cancer Patient Experience Survey. Br J Cancer. 2013 Aug 6;109(3):780-7.

  • Macmillan Cancer Support: "Is case-mix adjustment important for the National Cancer Patient Experience Survey in England (CPES)? A summary". 2014

Benaglia T, Sharples LD, Fitzgerald RC, Lyratzopoulos G. Health benefits and cost effectiveness of endoscopic and nonendoscopic cytosponge screening for Barrett's esophagus. Gastroenterology. 2013 Jan;144(1):62-73.e6.

  • The British Society of Gastroenterology: Guidelines on the diagnosis and management of Barrett's oesophagus". 2014.
2012

Publication:

Lyratzopoulos G, Neal RD, Barbiere JM, Rubin GP, Abel GA. Variation in number of general practitioner consultations before hospital referral for cancer: findings from the 2010 National Cancer Patient Experience Survey in England. Lancet Oncol. 2012 Apr;13(4):353-65.

Cited in:

  • National Cancer Strategy for England 2015-2020: Achieving World-Class Cancer Outcomes". 2015
  • The Lancet Oncology Commission: "The Expanding Role of Primary Care in Cancer Control". 2015
  • Cancer Research UK: "Early Detection and Diagnosis of Cancer Roadmap". 2020
  • Recomendaciones de prevención del cáncer. Actualización PAPPS 2018. Aten Primaria. 2018.
  • Cancer care Ontario: "Referral of Suspected Lung Cancer by Family Physicians and Other Primary Care Providers". 2019
  • CMS (US) Medicare Program: "Contract Year 2019 Policy and Technical Changes to the Medicare Advantage, Medicare Cos Plan, Medicare Fee-for-Service, the Medicare Prescription Drug Benefit Programs, and the PACE Program". 2019.
  • Macmillan Cancer Support: "Is case-mix adjustment important for the National Cancer Patient Experience Survey in England (CPES)? A summary". 2014
2011

Publication:

Lyratzopoulos G, Elliott MN, Barbiere JM, Staetsky L, Paddison CA, Campbell J, Roland M. How can health care organizations be reliably compared?: Lessons from a national survey of patient experience. Med Care. 2011 Aug;49(8):724-33.

Cited in:

  • Macmillan Cancer Support: "Is case-mix adjustment important for the National Cancer Patient Experience Survey in England (CPES)? A summary". 2014

 

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