CDB Seminars
All welcome


All Seminars are held in the Gavin De Beer Lecture Theatre, Anatomy Building, Thursday 1-2pm (unless otherwise stated)

Thursday 9 July: midday-2.40pm

Host: Yoshiyuki Yamamoto

Room 249, 2nd Floor, Medical Sciences Building, Gower Street

12.00pm  Heather Steele-Stallard: “Human iPS cell-based platforms for disease modelling and therapy screening for laminopathies”
12.15pm  Terry Felton: “Regulation of asymmetric neurogenesis in C. elegans
12.30pm  Marcus Ghosh: “Assigning Behavioural and Neurodevelopmental Functions to Autism-associated Genes”
12.45pm  Giulia Ferrari: “Towards a genomic integration-free, iPS cell and human artificial chromosome-based therapy for Duchenne muscular dystrophy”
1.00pm  Michele Sammut: “Mystery cells in C.elegans: Sex, Glia transdifferation and Learning”
1.15pm  Johanna Buchler: "The Wnt co-receptor LRP6 and synapse regulation".

1.40pm  Renato Martinho: “The Asymmetric Habenula of Zebrafish: from Transcriptome to Behaviour”
1.55pm  Alex Fedorec: “Plasmid persistence: balancing plasmid stability and host competitiveness”
2.10pm  Maryam Khosravi: "Investigating novel genetic associations with ciliopathy in the zebrafish"
2.25pm  Marc Williams: “Identification of neutral tumour evolution across cancer types”

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Dr Masazumi (Masa) Tada

Dr Masa Tada

Dr Masa Tada is a Reader in Developmental and Cellular Biology at the Research Department of Cell and Developmental Biology.


Office: 020 7679 6531
(Int: 46531)
Office: 020 7679 6331
(Int: 46331)

Dr Tada's Lab Website and Profile on School of Life & Medical Sciences Website

Research description

My research focuses on cellular and molecular mechanisms underlying co-ordinated and directed cell movements. The primary focus is coordinated and directed cell movements occurring during gastrualtion; epiboly, convergence/extension (CE) and anterior migration of prechordal mesoderm cells. CE is mediated by polarised mesenchymal cells in the notochord, which undergo directional cell intercalations by neighbour exchanges, contributing to the elongation of the body axis. In contrast, directed migration of polarised mesenchymal cells in the prechordal plate is mediated by collective cell migration in which the cells migrate as a cohesive cluster without neighbour exchanges involved. What co-ordinates cell behaviours underlying these different morphogentic processes? To address this question, we use the zebrafish as a model system based on time-lapse imaging analyses using genetic and developmental approaches.

Little was known about genetic and molecular pathways that regulate such coordinated cell behaviours until the end of 20th century. Since then we have shown that Wnt11 is a key regulator of CE movements during gastrulation in vertebrates (Heisenberg, Tada et al., 2000: Tada and Smith, 2000). However, it has been evident that this ligand acts in a pathway related to the planar cell polarity (PCP) pathway in Drosophila. Recently, the core PCP genes have been also implicated in regulating a variety of morphogenetic processes in vertebrates including neural tube closure, orientation of cochlear hair cells, migration of facial motorneurons and ciliogenesis (Tada and Kai, 2009; Tada and Kai, 2012). Given the similarities in cell behaviours during gastrulation and cancer metastasis, PCP genes are candidates showing altered activities during cancer progression.

Current topics in the lab are: 1) How the core PCP protein Flamingo/Celsr regulate cell adhesion and PCP signalling separately; 2) What regulates the mode of collective migration of prechordal mesoderm cells; and 3) How normal cells detect transformed cells in simple epithelia, and eliminate them apically or basally from the epithelia at initiation of carcinogenesis.

To further explore fundamental problems underlying morphogenesis, I collaborate with Steve Wilson in the zebrafish group, Jon Clarke (Kings College London), Paul Martin (Univ. Bristol) and Yasu Fujita (Hokkaido Univ., Japan).

Profile 1983 BSc, University of Tsukuba (Japan) 1986 MSc, University of Tsukuba (Japan) 1989 Research associate, National Cardiovascular Centre Research Institute (Japan) 1990 PhD, University of Tsukuba (Japan) 1993 Instructor with Prof. Naoto Ueno, Hokkaido University (Japan) 1995 Post-doc with Dr. Jim Smith, National Institute for Medical Research 2000 MRC Career Development Fellow, UCL 2005 Lecturer, UCL 

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Page last modified on 26 sep 14 12:54 by Edward D Whitfield