Dr Gyorgy Szabadkai
g.szabadkai (at) ucl.ac.uk
The interest of my research groups is to understand the role of mitochondria in cellular stress responses in major pathologies such as neurodegenerative disease and cancer. We use bioinformatics, biochemical, molecular biology and cellular imaging tools in collaboration with other mitochondrial biology and imaging groups at the UCL and UoP.
|Schematic outline of our research –Stress conditions, accompanying several pathologies like neurodegenerative diseases, diabetes and cancer induce adaptive responses in both the mitochondrial and ER networks. This includes an increased turnover of organelle biogenesis and degradation (autophagy). If adaptation fails, cells utilize different pathways to die. ER-mitochondrial crosstalk and transcriptional regulation of the mitochondrial proteome (biogenesis) determine both adaptive and death responses and thus will be a target of cellular stress signaling pathways.|
Lab members at UCL:
Robert Bentham (UCL COMPLeX, British Heart Foundation PhD fellow)
Julia Hill (Eisai funded PhD fellow)
Gregory Keen (Research Assistant, UCL-Eisai Therapeutic Innovation Group)
Thomas Briston (Research Assistant, UCL-Eisai Therapeutic Innovation Group)
Ronan Astin (Clinical PhD fellow)
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Page last modified on 26 sep 14 12:52 by Edward D Whitfield