UCL Research Department of Cell and Developmental Biology

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Dr Stephen Price

Stephen Price is a Lecturer in Developmental Neuroscience (since September 2003). He is the co-organiser of the MSc in Neuroscience degree of the Faculty of Life Sciences. He contributes to the teaching on this degree as well as to second and third year undergraduate degrees. stephen.price@ucl.ac.uk Telephone: 020 7679 3884 (UCL int: 33884)

Research

The Price group’s research interest is in how specificity is imparted to the formation of neuronal assemblies in the developing central nervous system. To address this research question, they focus on neuronal nucleus formation in the developing spinal cord and hindbrain. Currently, their focus is on a role for the cadherin family of cell adhesion molecules in directing specificity of cell interactions. However, they are also studying the roles of several other gene families.

Profile

1992 BA, Natural Sciences, Gonville and Caius College, Cambridge University
1997 PhD, Biology (B) MRC Laboratory of Molecular Biology, Cambridge
2000 Research Associate, Columbia University
2003 Helen Hay Whitney Fellow, Columbia University

Peer-Reviewed Publications

• Price, S. R., Ito, N., Oubridge, C., Avis, J. M., and Nagai, K. Crystallization of RNA-protein complexes. I. Methods for the large-scale preparation of RNA suitable for crystallographic studies. J Mol Biol 1995; 249, 398-408
• Price, S. R., Evans, P. R., and Nagai, K. Crystal structure of the spliceosomal U2B”-U2A’ protein complex bound to a fragment of U2 small nuclear RNA. Nature 1998; 394, 645-650.
• Price, S. R., DeMarco-Garcia N. V., Ranscht, B. and Jessell, T. M. Regulation of Motor Neuron Pool Sorting By Differential Expression of Type II Cadherins. Cell 2002; 109, 205-216
• Livet J., Sigrist M., Stroebel S., De Paola V., Price S.R., Henderson C.E., Jessell T.M. and Arber S. ETS Gene PEA3 Controls the Central Position and Terminal Arborization of Specific Motor Neuron Pools. Neuron 2002; 35, 877-892
• Patel, S. D., Ciatto, C., Chen, C. P., Bahna, F., Rajebhosale, M., Arkus, N., Schieren, I., Jessell, T. M. Honig, B., #Price, S. R., and Shapiro, L. Crystal structures of type II cadherin ectodomains: Implications for the functional specificity of classical cadherins. Cell 2006; 124, 1255-1268

# Corresponding author

• Invited reviews and Book chapters:
  Price, S. R. and Nagai K Protein engineering as a tool for crystallography. Curr Opin Biotechnol 1995; 6, 425-430
• Price, S., and Nagai K Secrets of RNA folding revealed. Structure 1996; 4, 1129-1132
• Price, S. R., Oubridge, C., Varani, G., and Nagai, K. Preparation of RNA:protein complexes for X-ray crystallography and NMR. In Smith C. W. R. ed RNA-protein interactions: A practical approach Oxford University Press, Oxford, UK. 1998, 30-68
• #Price, S. R. In Vivo Electroporation of Neurons. In Juste and Konnarth eds Imaging in Neuroscience and Development: A Laboratory Manual 2004; Cold Spring Harbor Laboratory Press, Cold Spring Harbor, USA.
• #Price, S. R. and Briscoe, J. The generation and diversification of spinal motor neurons: signals and responses. Mechanisms of Development. 2004; 121, 1103-1115
• Salinas, P. C. and #Price, S. R. Cadherins and Catenins in Synapse Development. Curr Opin Neurobiology. 2005; 15, 73-80

# Corresponding Author.