Lesley Sharpe predominantly works in print with an interest in hybrid processes, combining both traditional and digital techniques. Researching specific subjects relating to architecture and the anthropology of place as departure points, her work explores the conceptual and material interpretation of landscape through the printed image.

One strand of her practice centers around the production of fine art print in collaboration with and for artists. These have in part been produced through imprint The Small Press which she founded in 2008 and editions practice Holding Page co-founded in 2011. Recent projects include Ulla Von Brandenburg for the Whitechapel Gallery, London, Marc Camille Chaimowicz for Indipendenza Roma and Melanie Counsell for Matts Gallery, London.