Identifying eligible patients

We want to keep the inclusion criteria pragmatic and broad to reflect the current dilemma in clinical practice.

Eligible patients are those who:

  • are aged 18 to 74 years
  • are being treated for depression
  • have had at least 2 episodes of depression
  • have been taking antidepressants for 9 months or more
  • are currently taking either citalopram 20mg, sertraline 100mg, fluoxetine 20mg or mirtazapine 30mg per day
  • would consider stopping medication

Excluded are patients who:

  • still meet ICD10 criteria for a depressive illness despite treatment
  • have other psychiatric disorders, i.e. psychosis, schizophrenia, bipolar, mania, hypomania, dementia or terminal illness
  • have significant alcohol or substance abuse as their primary problem/s
  • are not able to complete the study questionnaires; or currently enrolled in another IMP trial
  • are taking contraindicated medications: monoamine oxidase inhibitors
  • women who are currently pregnant or planning pregnancy