Abnormal neuronal circuits in Alzheimer’s disease

Growing clinical and experimental evidence suggests the presence of a wide spectrum of abnormal brain activity ranging from asymptomatic neuronal hyperexcitability

to overt seizures in individuals with preclinical and prodromal Alzheimer’s disease (AD). There is, thus, great interest in better understanding the mechanisms and consequences

of these early functional deficits. In my talk, I will present data showing how Alzheimer-related amyloid (Abtea) plaques and tangles cause massive impairments in neuronal circuit physiology

that lead to memory problems – and that such impairments can be reversed only under certain conditions, which I believe has important implications for the next generation of clinical trials.

learning objectives: 

after the talk participants will be able to:

i) understand how neural circuit approaches hold promise for advancing understanding and novel treatments for Alzheimer´s disease

ii) understand the mechanisms of amyloid-beta and tau-related neural circuit dysfunctions

iii) understand the effects of clinically relevant Alzheimer´s therapeutics on neural circuits