Institute for the Physics of Living Systems


A Sticky-Spaghetti-with-Meatballs Model to Describe Nuclear Import

14 April 2016


A sticky-spaghetti-with-meatballs model may be sufficient to describe how the nucleus in each of our cells selectively allows the entrance and exit of certain molecules, while blocking others to protect genetic material and normal functions of the cell. That is the conclusion based on research by an international team of scientists, led by the London Centre for Nanotechnology and CIC biomaGUNE (San Sebastian, Spain), and published in the journal eLife.

More information can be found at the London Centre for Nanotechnology.

Journal link:

"A physical model describing the interaction of nuclear transport receptors with FG nucleoporin domain assemblies." Raphael Zahn, Dino Osmanović, Severin Ehret, Carolina Araya Callis, Steffen Frey, Murray Stewart, Changjiang You, Dirk Görlich, Bart W Hoogenboom, and Ralf P Richter. eLife (2016), http://dx.doi.org/10.7554/eLife.14119.

LCN Author(s): Dino Osmanović and Bart Hoogenboom