Institute for the Physics of Living Systems


Crick/IPLS Seminar - Prof. Raymond Goldstein (University of Cambridge)

07 February 2018, 2:00 pm

Event Information

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The Francis Crick Institute, Auditorium

Computational and Physical Biology Interest Group Seminar.

Title: Upside down and inside out: the biomechanics of cell sheet folding

Abstract: Deformations of cell sheets are ubiquitous in early animal development, often arising from a complex and poorly understood interplay of cell shape changes, division, and migration. In this talk I will describe an approach to understanding such problems based on perhaps the simplest example of cell sheet folding: the "inversion" process of the algal genus Volvox, during which spherical embryos literally turn themselves inside out through a process hypothesized to arise from cell shape changes alone. Through a combination of light sheet microscopy and elasticity theory a quantitative understanding of this process is now emerging.