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Experimental Psychology Seminar - Lisa Roux : Population bursts in Archicortices
05 December 2023, 1:00 pm–3:00 pm
Joining us for the next experimental psychology seminar on 5th December, 13:00, Lisa Roux PhD will discuss the role of sharp-wave ripples in the stabilization of the so-called ‘cognitive map’ coded by place cells in the hippocampus, and analogous activity patterns in the piriform cortex linked with olfaction, with insights from optogenetics and multi-electrode recordings.
Event Information
Open to
- All
Organiser
-
Antonietta Esposito
Location
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30526 Bedford WayLondonWC1H 0APUnited Kingdom
Venue:
Room 305 (26 Bedford Way)
Or you can also attend online via Zoom:
https://ucl.zoom.us/j/91596471848?pwd=WlRXdU1Zb0dCTkFMVlBLMkFkd2FmUT09
Meeting ID: 915 9647 1848
Passcode: 351386
Abstract
Sharp-wave ripples are network events observed in the hippocampal local field potential during slow wave sleep, quiet wakefulness and consummatory behaviors. They have been shown to orchestrate the “replay” of past activity patterns and are critical for memory consolidation. As hippocampal place cells code for specific locations in space, entire trajectories are reactivated during these network events. These replays are thought to facilitate the progressive strengthening of the connections that represent the original experience. In my presentation, I will discuss how fine optogenetic manipulations combined with multi-electrode recordings and closed-loop feedback tools allowed uncovering the role of sharp-wave ripples during spatial learning, specifically their role in the stabilization of the so-called ‘cognitive map’ coded by place cells in the CA1 region of the hippocampus. I will then share recent observations from another archicortex, the olfactory piriform cortex, which hosts population bursts of activity reminiscent of hippocampal ripples. We propose that studying hippocampus and piriform in parallel can improve our understanding of memory-related processes in olfaction and beyond.
About the Speaker
Lisa Roux
Research Team Leader - 'Olfaction and Memory' at Institute for Neuroscience, Bordeaux University, France
Lisa Roux is a researcher at CNRS leading the team “Olfaction and Memory” at the Interdisciplinary Institute for Neuroscience (IINS, CNRS UMR5297, Bordeaux University, France) since 2018. She did her PhD in the lab of Christian Giaume at the Collège de France where she worked on neuro-glial interactions in the olfactory system using primarily slice electrophysiology methods. Her work unraveled a bi-directional loop of interactions between neuron and astrocyte networks which could impact olfactory information processing. In 2012, Lisa Roux joined the lab of Gyorgy Buzsáki at the New York University (USA) as a postdoctoral fellow. There, she used advanced in vivo electrophysiology and optogenetic approaches in freely moving mice to understand the mechanisms of hippocampal oscillations and their function in spatial memory processes. Notably, she studied the cellular mechanisms involved in two types of network oscillations, fundamental to memory function in the hippocampus: theta and sharp wave ripple oscillations. Her work also uncovered that sharp wave ripple oscillations are central for stabilizing the hippocampal “cognitive map” during spatial learning. The role played by inhibitory interneurons in shaping circuit functions in the behaving animal was at the core of her work. As an independent group leader at the IINS, she broadened her field of investigation by studying the dialog between sensory and hippocampal networks.
Lisa Roux has been the recipient of the Bettencourt-Schueller Foundation Award for Young Scientists (2013, France), a K99 National Institute of Health Pathway to Independence Award (2015, U.S.A.), a Junior Chair by the Initiative of Excellence of the Bordeaux University (2017, France), an ATIP-Avenir Grant (2017, France) and an ERC Starting Grant (2019). In October 2018, she received the Paoletti Prize discerned by the INSB (CNRS, France). In 2021, she became a laureate of the Fondation Schlumberger pour l’Education et la Recherche.
More about Lisa Roux