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UCL Centre for Clinical Research in Infection and Sexual Health - Research Projects

Short TitleFull TitleName of PIStart/End DateCurrent/Completed/Archived
CIPHERCIPHER - study of cognitive function in HIV+ people.Lewis Haddow Current
EuroSIDA Cohort XEuroSIDA Cohort X: Observational cohort study collecting clinical and demographic data for coinfected HIV/HCV positive adults.Simon Edwards Current
PrEP IMPACT TrialPrEP IMPACT Trial: A pragmatic health technology assessment of PrEP and implementation.Richard GilsonOct 2017 - currentCurrent
Flu StudyInfluenza acquisition in Health Care Workers who work on a dedicated influenza cohort wardRichard Gilson Current
DISCOVERGS-US-412-2055: A Phase 3, Randomized, Double-blind Study to Evaluate the Safety and Efficacy of Emtricitabine and Tenofovir Alafenamide (F/TAF) Fixed-Dose Combination Once Daily for Pre-Exposure Prophylaxis in Men and Transgender Women Who Have Sex with Men and Are At Risk of HIV-1 InfectionRichard Gilson Current
PARTNERPARTNER 2.0: A study in HIV sero-different partnerships to estimate the rate of transmission of HIV and to investigate factors associated with condom useRichard Gilson Current
SAFETXTSafetxt: randomised controlled trial of safer sex intervention delivered through mobile phone messagingJohn SaundersAug 2016 - currentCurrent
JENNER IIVirus and host immune system interaction during HIV-1 infection (JENNER II): Longitudinal study collecting blood samples at recruitment & clinic visits from PHI & ART-naïve participantsIan Wiliams Current
HIV BIORESOURCEHIV BioResource: HIV +ve, one-time blood sample to be stored and used for future genetic research.Fiona BurnsMay 2014 - currentCurrent
STOP HCV-1STOP HCV-1: Stratified Treatment OPtimisation for HCV-1: An open-label randomised controlled trial (RCT) testing biomarker-stratified short-course first-line and re-treatment direct-acting antiviral (DAA) oral treatment regimens to cure mild chronic Hepatitis C (HCV) disease.Richard GilsonNov 2017 - currentCurrent
MAVMETMAVMET: a multicentre, 48 week randomised controlled factorial trial of adding Maraviroc and/or Metformin for hepatic steatosis in HIV-1-infected adults on combination antiretroviral therapySarah PettMar 2018 - currentCurrent
AMBERAMBER - randomised, double-blind study to evaluate efficacy and safety of DRV/cobicistat/FTC/TAF vs. DRV/cobicistat fixed dose combination plus Truvada®Laura WatersNov 2015 - currentCurrent
EMERALDEMERALD: randomized, active-controlled, open-label study to evaluate the efficacy and safety of switching to a D/C/F/TAF once-daily single-tablet regimen versus continuing the current regimen consisting of a boosted protease inhibitor (bPI) combined with FTC/TDFLaura WatersApr 2015 - currentCurrent
RIVERRIVER - Research in Viral Eradication of HIV Reservoirs - a functional cure studySarah Pett Current
DRIVE AHEADMK-1439A-021: Double-Blind, Randomised Trial of Safety and Efficacy of FDC of TDF/3TC/doravirine (MK1439A) Once Daily vs Atripla® in Treatment Naïve HIV-positivesIan Wiliams Current
DRIVE SHIFTMK-1439A-024: randomised study evaluating immediate vs deferred switch to  FDC of TDF/3TC/doravirine in patients stable and suppressed on a PI/r+2NRTIIan Wiliams Current
GS 380-1489GS-US-380-1489: A phase 3, randomised, Double Blind Study to Evaluate the Safety and Efficacy of GS9883/FTC/TAF vs. Triumeq in HIV-1 Infected, Antiretroviral Treatment Naïve AdultsLaura WatersJun 2016 - currentCurrent
GS 380-1490GS-US-380-1490: A Phase 3, Randomised, Double Blind Study of the Safety and Efficacy of a Fixed Dose combination of GS9883/FTC/TAF vs. DOL/FTC/TAF in HIV-1 infected, Antiretroviral Treatment- Naïve AdultsLaura WatersJune 2016 - currentCurrent
STARTStrategic Timing of AntiRetroviral Treatment (START): Randomized study to determine whether immediate initiation of antiretroviral treatment (ART) is superior to deferral of ART until the CD4+ declines below 350 cells/mm3Ian Wiliams Current
FLAIRFLAIR: A Phase III, Randomized, Multicenter, Parallel-group, Open-Label Study Evaluating the Efficacy and Safety of Long-Acting Intramuscular Cabotegravir and Rilpivirine for Maintenance of Virologic Suppression Following Switch from an Integrase Inhibitor Single Tablet Regimen in HIV-1 Infected ART-Naive Adult ParticipantsSarah PettNov 2016 - currentCurrent
HIPVacHIPvac: Randomised controlled trial of Imiquimod cream vs. podophyllotoxin in combination with quadrivalent HPV or control vaccination in the treatment and prevention of recurrence of anogenital warts.Richard GilsonFeb 2014 - currentCurrent
BESTTBESTT WOMEN's STUDY: Bone Evaluation in HIV positive women who switch from Truvada/NNRTI to TriumeqLaura WatersMay 2016 - currentCurrent
TANGOA Phase III, randomized, multicenter, parallel-group, non-inferiority study evaluating the efficacy, safety, and tolerability of switching to dolutegravir plus lamivudine in HIV-1-infected adults who are virologically supressed  Sarah PettApril 2018 - OngoingCurrent
VITAVITA: A randomised controlled trial to assess the clinical and cost effectiveness of topical lactic acid gel for treating second and subsequent episodes of bacterial vaginosisRichard GilsonNov 2017 - currentCurrent
 Characterising and modifying immune responses in chronic viral hepatitis - collection of blood samples from patients with HBV and HCVRichard Gilson Current
Tpal-Omics StudySyphilis Transcriptomics: Proof of concept study that aims to utilise next generation sequencing and transcriptomic approaches to understand infection with Treponema pallidumPatrick FrenchOct 2017 - currentCurrent
Elite ControllersHIV elite controllers: Comprehensive assessment of host factors associated with HIV-1 elite controlRavi Gupta Current
POPPYPOPPY: A prospective, observational study to examine the effects of ageing on the clinical outcomes of people living with HIV in England and IrelandIan Wiliams Current
POPPY SleepPOPPY Sleep Substudy: study looking at the effects of being HIV positive and being on antiretroviral medication may have on sleeping and sleep patternLewis HaddowMar 2018 - currentCurrent
EuroSIDA Cohort 9EuroSIDA Cohort 9: Observational cohort study collecting clinical and demographic data for HIV-positive adults.Simon Edwards Current
APARTAlendronate for Prevention of AntiRetroviral Therapy-associated bone loss (APART Study)Lewis Haddow Current
HPV Sampling StudyHPV Sampling Study: A study to evaluate the performance of human papillomavirus (HPV) DNA detection in residual specimens taken for Chlamydia trachomatis/Neisseria gonorrhoea nucleic acid amplification testing in men who have sex with men (MSM)Diarmuid NugentJan 2018 - currentCurrent
UK HDRDUK HIV Drug Resistance DatabaseDavid Dunn2001 - currentCurrent
IconaIcona NetworkAlessandro Cozzi-LepriSept 1997 - currentCurrent
PersimunePERSIMUNEAmanda MorcroftJan 2015 - currentCurrent
Insight FluINSIGHT Influenza StudiesAlessandro Cozzi-LepriSept 2009 - currentCurrent
GS 292-1823GS-US-292/1823: A Phase 3b, Randomised, Open-Label Study to Evaluate the Safety and Efficacy of Switching from Regimens Consisting of ABC/3TC plus a Third Antiretroviral Agent to the E/C/F/TAF Fixed-Dose Combination (FDC) in Virologically-Suppressed HIV-1 Infected Adult SubjectsLaura WatersSep 2016 - May 2018Completed
GS 292-1826GS-US-292-1826: A Phase 3b, Randomised, Open-Label Study to Evaluate Switching from a TDF Containing Regimen to E/C/F/TAF Fixed-Dose Combination (FDC) in Virologically-Suppressed, HIV-1 Infected Subjects Aged ≥ 60 YearsLaura WatersAug 2016 - Mar 2018Completed
PRIMEPRIME: Quantitative and qualitative study that will exploring the impact of the menopause on HIV-positive women's health and wellbeingShema TariqJan 2016 - Oct 2017Completed
CASSCASS trialAlessandro Cozzi-LepriJuly 2008 - Mar 2017Completed