Short Title	Full Title	Name of PI	Start/End Date	Current/Completed/Archived
CIPHER	CIPHER - study of cognitive function in HIV+ people.	Lewis Haddow		Current
EuroSIDA Cohort X	EuroSIDA Cohort X: Observational cohort study collecting clinical and demographic data for coinfected HIV/HCV positive adults.	Simon Edwards		Current
PrEP IMPACT Trial	PrEP IMPACT Trial: A pragmatic health technology assessment of PrEP and implementation.	Richard Gilson	Oct 2017 - current	Current
Flu Study	Influenza acquisition in Health Care Workers who work on a dedicated influenza cohort ward	Richard Gilson		Current
DISCOVER	GS-US-412-2055: A Phase 3, Randomized, Double-blind Study to Evaluate the Safety and Efficacy of Emtricitabine and Tenofovir Alafenamide (F/TAF) Fixed-Dose Combination Once Daily for Pre-Exposure Prophylaxis in Men and Transgender Women Who Have Sex with Men and Are At Risk of HIV-1 Infection	Richard Gilson		Current
PARTNER	PARTNER 2.0: A study in HIV sero-different partnerships to estimate the rate of transmission of HIV and to investigate factors associated with condom use	Richard Gilson		Current
SAFETXT	Safetxt: randomised controlled trial of safer sex intervention delivered through mobile phone messaging	John Saunders	Aug 2016 - current	Current
JENNER II	Virus and host immune system interaction during HIV-1 infection (JENNER II): Longitudinal study collecting blood samples at recruitment & clinic visits from PHI & ART-naïve participants	Ian Wiliams		Current
HIV BIORESOURCE	HIV BioResource: HIV +ve, one-time blood sample to be stored and used for future genetic research.	Fiona Burns	May 2014 - current	Current
STOP HCV-1	STOP HCV-1: Stratified Treatment OPtimisation for HCV-1: An open-label randomised controlled trial (RCT) testing biomarker-stratified short-course first-line and re-treatment direct-acting antiviral (DAA) oral treatment regimens to cure mild chronic Hepatitis C (HCV) disease.	Richard Gilson	Nov 2017 - current	Current
MAVMET	MAVMET: a multicentre, 48 week randomised controlled factorial trial of adding Maraviroc and/or Metformin for hepatic steatosis in HIV-1-infected adults on combination antiretroviral therapy	Sarah Pett	Mar 2018 - current	Current
AMBER	AMBER - randomised, double-blind study to evaluate efficacy and safety of DRV/cobicistat/FTC/TAF vs. DRV/cobicistat fixed dose combination plus Truvada®	Laura Waters	Nov 2015 - current	Current
EMERALD	EMERALD: randomized, active-controlled, open-label study to evaluate the efficacy and safety of switching to a D/C/F/TAF once-daily single-tablet regimen versus continuing the current regimen consisting of a boosted protease inhibitor (bPI) combined with FTC/TDF	Laura Waters	Apr 2015 - current	Current
RIVER	RIVER - Research in Viral Eradication of HIV Reservoirs - a functional cure study	Sarah Pett		Current
DRIVE AHEAD	MK-1439A-021: Double-Blind, Randomised Trial of Safety and Efficacy of FDC of TDF/3TC/doravirine (MK1439A) Once Daily vs Atripla® in Treatment Naïve HIV-positives	Ian Wiliams		Current
DRIVE SHIFT	MK-1439A-024: randomised study evaluating immediate vs deferred switch to  FDC of TDF/3TC/doravirine in patients stable and suppressed on a PI/r+2NRTI	Ian Wiliams		Current
GS 380-1489	GS-US-380-1489: A phase 3, randomised, Double Blind Study to Evaluate the Safety and Efficacy of GS9883/FTC/TAF vs. Triumeq in HIV-1 Infected, Antiretroviral Treatment Naïve Adults	Laura Waters	Jun 2016 - current	Current
GS 380-1490	GS-US-380-1490: A Phase 3, Randomised, Double Blind Study of the Safety and Efficacy of a Fixed Dose combination of GS9883/FTC/TAF vs. DOL/FTC/TAF in HIV-1 infected, Antiretroviral Treatment- Naïve Adults	Laura Waters	June 2016 - current	Current
START	Strategic Timing of AntiRetroviral Treatment (START): Randomized study to determine whether immediate initiation of antiretroviral treatment (ART) is superior to deferral of ART until the CD4+ declines below 350 cells/mm3	Ian Wiliams		Current
FLAIR	FLAIR: A Phase III, Randomized, Multicenter, Parallel-group, Open-Label Study Evaluating the Efficacy and Safety of Long-Acting Intramuscular Cabotegravir and Rilpivirine for Maintenance of Virologic Suppression Following Switch from an Integrase Inhibitor Single Tablet Regimen in HIV-1 Infected ART-Naive Adult Participants	Sarah Pett	Nov 2016 - current	Current
HIPVac	HIPvac: Randomised controlled trial of Imiquimod cream vs. podophyllotoxin in combination with quadrivalent HPV or control vaccination in the treatment and prevention of recurrence of anogenital warts.	Richard Gilson	Feb 2014 - current	Current
BESTT	BESTT WOMEN's STUDY: Bone Evaluation in HIV positive women who switch from Truvada/NNRTI to Triumeq	Laura Waters	May 2016 - current	Current
TANGO	A Phase III, randomized, multicenter, parallel-group, non-inferiority study evaluating the efficacy, safety, and tolerability of switching to dolutegravir plus lamivudine in HIV-1-infected adults who are virologically supressed	Sarah Pett	April 2018 - Ongoing	Current
VITA	VITA: A randomised controlled trial to assess the clinical and cost effectiveness of topical lactic acid gel for treating second and subsequent episodes of bacterial vaginosis	Richard Gilson	Nov 2017 - current	Current
	Characterising and modifying immune responses in chronic viral hepatitis - collection of blood samples from patients with HBV and HCV	Richard Gilson		Current
Tpal-Omics Study	Syphilis Transcriptomics: Proof of concept study that aims to utilise next generation sequencing and transcriptomic approaches to understand infection with Treponema pallidum	Patrick French	Oct 2017 - current	Current
Elite Controllers	HIV elite controllers: Comprehensive assessment of host factors associated with HIV-1 elite control	Ravi Gupta		Current
POPPY	POPPY: A prospective, observational study to examine the effects of ageing on the clinical outcomes of people living with HIV in England and Ireland	Ian Wiliams		Current
POPPY Sleep	POPPY Sleep Substudy: study looking at the effects of being HIV positive and being on antiretroviral medication may have on sleeping and sleep pattern	Lewis Haddow	Mar 2018 - current	Current
EuroSIDA Cohort 9	EuroSIDA Cohort 9: Observational cohort study collecting clinical and demographic data for HIV-positive adults.	Simon Edwards		Current
APART	Alendronate for Prevention of AntiRetroviral Therapy-associated bone loss (APART Study)	Lewis Haddow		Current
HPV Sampling Study	HPV Sampling Study: A study to evaluate the performance of human papillomavirus (HPV) DNA detection in residual specimens taken for Chlamydia trachomatis/Neisseria gonorrhoea nucleic acid amplification testing in men who have sex with men (MSM)	Diarmuid Nugent	Jan 2018 - current	Current
UK HDRD	UK HIV Drug Resistance Database	David Dunn	2001 - current	Current
Icona	Icona Network	Alessandro Cozzi-Lepri	Sept 1997 - current	Current
Persimune	PERSIMUNE	Amanda Morcroft	Jan 2015 - current	Current
Insight Flu	INSIGHT Influenza Studies	Alessandro Cozzi-Lepri	Sept 2009 - current	Current
GS 292-1823	GS-US-292/1823: A Phase 3b, Randomised, Open-Label Study to Evaluate the Safety and Efficacy of Switching from Regimens Consisting of ABC/3TC plus a Third Antiretroviral Agent to the E/C/F/TAF Fixed-Dose Combination (FDC) in Virologically-Suppressed HIV-1 Infected Adult Subjects	Laura Waters	Sep 2016 - May 2018	Completed
GS 292-1826	GS-US-292-1826: A Phase 3b, Randomised, Open-Label Study to Evaluate Switching from a TDF Containing Regimen to E/C/F/TAF Fixed-Dose Combination (FDC) in Virologically-Suppressed, HIV-1 Infected Subjects Aged ≥ 60 Years	Laura Waters	Aug 2016 - Mar 2018	Completed
PRIME	PRIME: Quantitative and qualitative study that will exploring the impact of the menopause on HIV-positive women's health and wellbeing	Shema Tariq	Jan 2016 - Oct 2017	Completed
CASS	CASS trial	Alessandro Cozzi-Lepri	July 2008 - Mar 2017	Completed