UCL Great Ormond Street Institute of Child Health


Great Ormond Street Institute of Child Health


Genomic Impact on Intellectual Disability and Mental Health

IMAGINE ID - Intellectual Disability and Mental Health: Assessing Genomic Impact on Neurodevelopment

Why is research needed?

When a child is diagnosed with a rare genetic change there is often limited knowledge available for doctors to answer parents' next question: "So what does this mean for my child?" IMAGINE ID aims to answer this question by investigating the relationship between genetic changes, development and behaviour in children with intellectual disability.

What are our aims?

IMAGINE ID is a research project funded by the Medical Research Council. We are a team of researchers from the University of Cambridge, University College London, and Cardiff University. We are committed to understanding the genomic and developmental factors predictive of mental health outcomes in children and young people with intellectual disability. To do so, we will build the world's biggest database linking genetic information to attainment of developmental milestones, behaviour and wellbeing in the intellectually disabled population. The IMAGINE ID cohort and datasets will create extensive opportunities for future translational research.

What do we plan to do?

We are aiming to recruit 500 participants during our pilot phase until September 2015. With the possibility of funding for a further 4 years to expand the sample to 10,000 participants. Taking part in the IMAGINE ID study involves families filling out an online questionnaire about their child's wellbeing and development.

Main contact

Research team

  • David Skuse
  • Lucy Raymond, University of Cambridge
  • Jeremy Hall, University of Cardiff
  • Marianne van den Bree, University of Cardiff

UCL Research Assistant Team


  • Medical Research Council (MRC)

Useful links