UCL Great Ormond Street Institute of Child Health


Great Ormond Street Institute of Child Health

Dr Paula Alexandre

Dr Paula Alexandre

Lecturer (Research Group Leader)

Developmental Biology & Cancer Dept

UCL GOS Institute of Child Health

Joined UCL
1st Jun 2013

Research summary

My lab studies the cellular and molecular mechanisms that regulate neurogenesis during brain and spinal cord development. We currently use live-imaging and genetic approaches in zebrafish embryos to determine the molecular mechanisms that regulate self-renewal and neuronal differentiation and pattern. We are expanding these studies to human developing hindbrain.

Teaching summary

I'm co-leading the MsC module in "Molecular Biology of Normal development and Birth Defects" (CHLD0070), and the 3rd year BsC module in "Birth Defects: Basic Research to Clinical Application". (ANAT0024). I'm a lecturer in "Developmental Neuroscience" (ANAT0023) in the MsC Neuroscience at UCL.


University College London
Doctorate, Fellowship of the Higher Education Academy | 2016
Universite Pierre et Marie Curie (Paris VI)
Doctorate, Doctor of Philosophy | 2005
Universidade de Lisboa
Other qualifications at first-degree level (including professional), Licenciatura | 2000


In 2000 I graduated in Biochemistry at Lisbon University and moved to Paris to start my PhD in Dr Wassef‘s laboratory at Paris VI. In 2006 I joined Professor Clarke’s laboratory at University College London (UCL) and later at King's College London as a Post Doctoral Research Fellow. In 2012 I was awarded a Dorothy Hodgkin fellowship and later moved to UCL GOS Institute of Child Health as a lecturer to continue studying the mechanisms of neurogenesis at the origin of developmental brain defects.